-
Systemic kanamycin treatment has no effect on cell numbers in the mouse utricular maculaKirkegaard, Mette ...The aim of the present study is to estimate the total number of the sensory hair cells (chalice innervated and bouton innervated) and supporting cells in the mouse utricular sensory epithelium at two ... different time points after systemic kanamycin treatment. Mice were given two daily subcutaneous injections of kanamycin (600 or 900 mg/kg) for 15 consecutive days and allowedto survive either 1 or 3 weeks after end of treatment. Cell numbers were estimated using a physical fractionator. Paraffin-embedded tissue was immunohistochemically stained for active caspase-3 in order to detect apoptosis. There was no change in hair cell or supporting cell number after treatment with kanamycin and the survival time had no effect. Although no positive staining for caspase-3 was seen, hair cells with swollen chalices anddark stained nuclei were observed in the sensory epithelium of the treated animals, indicating some effect of the treatment. In conclusion, the dosing regime and survival times studied here are not sufficient to induce hair cell loss in the mouse utricle.Vir: Image analysis & stereology : official journal of the International Society for Stereology. - ISSN 1580-3139 (Vol. 24, no. 2, jun. 2005, str. 69-76)Vrsta gradiva - članek, sestavni delLeto - 2005Jezik - angleškiCOBISS.SI-ID - 20111833
Avtor
Kirkegaard, Mette |
Severinsen, Stig Å |
Wogensen, Lise |
Nyengaard, Jens Randel
Teme
Saccule And Utricle |
Drug Effects |
Cytology |
Kanamycin |
Hair Cells, Inner |
Mice, Inbred Balb C |
Immunohistochemistry |
Cell Count |
Image Processing, Computer-Assisted |
Dlakaste celice notranje |
Kanamicin |
Sakula in utrikula |
Celica, štetje |
Imunohistokemija |
Miši seva BALB C |
Slika, obdelava z računalnikom |
aminoglikozidi |
kanamicin |
celice |
dlake |
epitelij |
stereologija |
miši
vir: Image analysis & stereology : official journal of the International Society for Stereology. - ISSN 1580-3139 (Vol. 24, no. 2, jun. 2005, str. 69-76)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Kirkegaard, Mette | |
Severinsen, Stig Å | |
Wogensen, Lise | |
Nyengaard, Jens Randel |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi