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  • Molecular biology of the lung cancer
    Panov, Sasho Z.
    Background. Lung cancer is one of the most common malignant diseases and leading eause of cancer death worldwide. The advances in molecular biology andgenetics, including the modern microarray ... technology and rapid sequencing techniques, have enabled a remarkable progress into elucidating the lung cancer ethiopathogenesis. Numerous studies suggest that more than 20 differentgenetic and epigenetic alterations are accumulating during the pathogenesis of clinically evident pulmonary cancers as a clonal, multistep process. Thus far, the most investigated alterations are the inactivational mutations and losses of tumour suppressorgenes and the overexpression of growth-promoting oneogenes. More recently, the acquired epigenetic inactivation of tumour suppressor genes by promoter hypermethylation has been recognized. The early clonal genetic abnormalities that occur in preneoplasticbronchial epithelium damaged by smoking or other carcinogenes arebeing identified. The molecular distinctions between small cell lung cancer(SCLC) and non-small cell lung cancer (NSCLC), as well as between turnors with different clinical outcomes have been described. These investigations lead to the "hallmarks of lung cancer". Conclusions. It is realistie to expect that the molecular and cell culture-based investigations will lead to diseoveries of new clinical applications with the potential to provide new avenues for early diagnosis, risk assessment, prevention, and mostimportant, new more effective treatment approaches for the lung cancer patients.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 39, no. 3, sep. 2005, str. 197-210)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 20504793

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 39, no. 3, sep. 2005, str. 197-210)

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