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Učinkovitost antiagregacijskega zdravljenja po perkutani koronarni intervenci pri bolnikih s stabilno angino pektoris = Efficacy of antiplatelet therapy in patients with stable angina pectoris undergoing percutaneous coronary interventionsČerne, Andreja, 1967- ...There is considerable heterogeneity in the individual response to antithrombotic treatment. We aimed to investigate the effect of body mass index (BMI) on response to clopidogrel treatment. Methods. ... We included 33 consecutive patients with stable angina pectoris who underwent percutaneous coronary intervention (PCI) with stent insertion. AV patients were on aspirin 100 mg daily. A loading dose of clopidogrel 600 mg was administered immediately after stent placement, and maintenance dose of clopidogrel 75 mg was given for at least 1 month thereafter. Platelet aggregation in response toADP, P-selectin expression and the Impact cone and platelet assay were evaluated at baseline, 24 hours and at one month after PCI. We compared different groups of patients based on their BMI. Clinical outcomes were also evaluated. Results Clopidogrel significantly decreased ADP-induced platelet aggregation at 24 hr and at 30 days after stent placement (47.1 t+-13.6% 27.5 +- 12.9% 35.5 +- 13.8% ANOVA p < 0.0001). There was no statistically significant deviations in P-selectin expression (2.3 +- 1.1%,1.9 +-0.9%,1.9 +-0.9% p = ns). Platelet inhibition was not affected by BMI. Aspirin and clopidogrel resistance was found in 3.0°/ and 9.1 I of patients, respectively.Conclusions. In patients treated with aspirin, clopidogrel provides additional inhibition of platelet aggregation after loading dose as well as after one month period of treatment. The antiplatelet effect of clopidogrel was not affected by BMI. The connection between thrombotic complications and antiplatelet drug resistance was not established.Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 4, št. 2, 2007, str. 76-80)Vrsta gradiva - članek, sestavni delLeto - 2007Jezik - slovenskiCOBISS.SI-ID - 23493593
Avtor
Černe, Andreja, 1967- |
Bajc, Barbara, dr. med. |
Kokalj, Anja, dr. med. |
Kranjec, Igor, 1946- |
Bunc, Matjaž
Teme
Angina Pectoris |
Angioplasty, Transluminal, Percutaneous Coronary |
Stents |
Platelet Aggregation Inhibitors |
Aspirin |
Body Mass Index |
Platelet Aggregation |
Drug Resistance |
Angina pektoris |
Angioplastika transluminalna, perkutana, koronarna |
Aspirin |
Opornice |
Trombociti, zlepljenje, inhibitorji |
Telesna masa, indeks |
Trombociti, agregacija |
Zdravilo, rezistenca |
kardiovaskularne bolezni |
angina pectoris |
zdravljenje |
zdravila |
antiagregacijsko zdravljenje
vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 4, št. 2, 2007, str. 76-80)
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Černe, Andreja, 1967- | 16254 |
Bajc, Barbara, dr. med. | |
Kokalj, Anja, dr. med. | |
Kranjec, Igor, 1946- | 08592 |
Bunc, Matjaž | 15667 |
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