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  • Motnje hemostaze pri bolnici s primarno AL-amiloidozo - prikaz primera = Hemostatic disorders related to primary AL amyloidosis - a case report
    Petric, Vlasta ; Cvetko Weiss, Valerija
    Background Primary AL amyloidosis is characterized by tissue deposits of amyloid, leading to organ dysfunction. Acquired hemostatic abnormalities including increased fragility of blood vessels, ... platelet dysfunction and coagulation factor deficiencies are common. Improved outcome of disease with poor prognosis is shown after a chemotherapy-induced decrease in plasma cell clone and impaired amiloid deposition. Patient and methods We report about a case of 63 year old women with spontaneus bleedings by who the primary AL amyloidosis was confirmed. She had impaired platelet aggregation, coagulation factor X deficiency, liver, kidney, spleen, peripheral nerves and heart involvement. Because of advanced stage of disease she was not a candidate for autologous stem cell transplantation. She received monthly courses of melphalan and dexamethasone. After three courses only the proteinuria decreased. Because of bleeding diathesis and heart involvement the outcome remains unpredictible. Conclusions For patients with primary AL amyloidosis isimportant to identify hemostatic disorders. Effect of chemoterapy is often delayed and during that time bleedings may complicate the course of disease.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, supl. 1, apr. 2008, str. I-125-I-128)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2008
    Jezik - slovenski
    COBISS.SI-ID - 24132313

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    Digitalna knjižnica Slovenije - dLib.si

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