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  • Cirkadiani ritmi in depresija = Circadian rhytmicity and depression
    Pregelj, Peter
    Background Depression is the most common psychiatric syndrome treated on the primary level. Abnormal patterns of circadian rhythms are associated with a large variety of affective disorders including ... depression. Sleep disruption isone of the major symptoms in depression, with majority of patients with major depression reporting difficulties with their sleep. In humans, the biological clock is the site of generation of entrainment of circadian rhythms. It is located in the suprachiasmatic nuclei of the anterior hypothalamus and is functionally interconnected with the melatonergic system. Melatonergic receptors type 1 and 2 participate in the regulation of the suprachiasmatic nucleus activity. When stimulated, receptors type 1 mediate the amplitude of the suprachiasmatic nucleus activity while receptors type 2 control phase shifting of the same activity. On the neurobiological level, depression is complex mood disorder that is also associated with the functional impairment of several central nervous systems including noradrenergic, serotonergic and dopaminergic transmitters and several hormonalsystems. Conclusions There is a grooving evidence that dysfunction in circadian rhythm regulation and melatonergic system function is involved in depression pathogenesis. It is known that clinically used antidepressants haveinfluence on melatonergic system, probably through changed ratio between melatonergic type 1 and 2 receptors. With the clinical use of new compounds like agomelatine that directly regulates melatonergic system new opportunitiesin depression treatment emerged.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, št. 11, nov. 2008, str. 767-771)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - slovenski
    COBISS.SI-ID - 25151193

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