UNI-MB - logo
UMNIK - logo
 
Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Določanje vsebnosti terbinafinijevega hidroklorida v plazmi in dlaki mačk z uporabo nove izokratske metode HPLC = Determination of the terbinafine hydrochloride levels in cat's plasma and hair using a new developed isocratic HPLC method
    Kožuh Eržen, Nevenka ; Kužner, Jernej ; Drobnič-Košorok, Marinka
    The incidence of dermatophytosis in animals and humans has been increasing rapidly in recent years. Clinical investigations indicate high treatment activity of terbinafine hydrochloride against ... several dermatophytes. Its efficiency was tested in treatment of microsporiosis in cats as well. The distribution of terbinafine hydrochloride in cat's hair and plasma is important for the identification of the drug efficiency. A fast and reliable isocratic reversed-phase high performance liquid chromatographic method with suitable sample preparation has been developed. Reliability, good reproducibility and low detection limit (LOD 0.25 ng/ml) of the method enable the determination of terbinafine hydrocloride in hair and also in plasma of infected cats. The method is also appropriate for the determination of a terminal half-life of terbinafine hydrochloride in vatćs hair. Continous determination of the levels of terbinafine hydrochloride in catćs plasma and hair allows the performance of pharmacokinetic calculations.
    Vir: Zbornik Veterinarske fakultete = Research reports [of the] Veterinary Faculty. - ISSN 0353-8044 (Letn. 36, št. 2, 1999, str. 201-209)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - slovenski
    COBISS.SI-ID - 758138

Vnos na polico