Onkološki inštitut Ljubljana (OILJ)
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Association of circulating tumor cells, megakaryocytes and a high immune-inflammatory environment in metastatic breast cancer [Elektronski vir]Grašič-Kuhar, Cvetka ...Liquid biopsy is becoming an important source of new biomarkers during the treatment of metastatic cancer patients. Using size-based microfluid technology, we isolated circulating tumor cells (CTCs) ... from metastatic breast cancer patients to evaluate their presence and cluster formation, as well as the presence of megakaryocytes and immune-inflammatory blood cells, and to correlate their presence with clinicopathological data and overall survival (OS). In total, 59 patients (median age 60.4 years) were included in the study: 62.7% luminal A/B-like, 20.3% HER2-positive, and 17% triple-negative. Our results showed that at least one CTC was present in 79.7% and ≥5 CTCs in 35.2% of the patients. CTC clusters were present in patients with ≥5 CTCs only (in 19.2% of them), and megakaryocytes were present in 52% of all patients. The presence of CTC clusters and megakaryocytes was positively associated with the CTC count. Patients with low pan-inflammatory value (PIV), low systemic immune-inflammatory index (SII), and low relative change from baseline (ΔPIV%, ΔSII%) were associated with significantly higher OS than their counterparts. ΔPIV%, the presence of infection in the last month, and a long duration of metastatic disease were identified as independent prognostic factors for OS. The interplay of CTCs, CTC clusters, megakaryocytes, and PIV needs to be further explored.Vir: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 15, no. 13, 2023, 3397-1-3397-18)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 160457987
Avtor
Grašič-Kuhar, Cvetka |
Jernej, Silvester |
Mencinger, Marina |
Ovčariček, Tanja |
Čemažar, Maja |
Miceska, Simona |
Pišljar, Živa |
Kuhar, Anamarija |
Jesenko, Tanja |
Kloboves-Prevodnik, Veronika
Teme
rak dojke |
kroženje tumorskih celic |
preživetje |
breast cancer |
circulating tumor cell |
overall survival
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Grašič-Kuhar, Cvetka | 15875 |
Jernej, Silvester | ![]() |
Mencinger, Marina | 25174 |
Ovčariček, Tanja | 54060 |
Čemažar, Maja | 14575 |
Miceska, Simona | 51443 |
Pišljar, Živa | 54718 |
Kuhar, Anamarija | ![]() |
Jesenko, Tanja | 33227 |
Kloboves-Prevodnik, Veronika | 15076 |
Vir: Osebne bibliografije
in: SICRIS
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