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Prognostic value of C-reactive protein and other classical factors in patients with advanced non-small cell lung carcinoma treated in routine clinical practice = Napovedna vrednost C-reaktivnega proteina in drugih dejavnikov pri bolnikih z napredovalim nedrobnoceličnim karcinomom pljuč zdravljenih rutinsko v klinični praksiOvčariček, Tanja ...Background: Prognostic factors may help the clinician in treatment decision making. The significance of C-reactive protein (CRP) as a negative prognostic factor has been shown in patients with ... different malignancies. However, only few studies have analyzed CRP as a prognostic factor in patients with advancednon-small cell lung cancer (NCLCS). The aim of this study was to evaluate the prognostic value of CRP and other prognostic factors in a group of unselected population of patients with advanced NCLSC treated with platinumbased chemotherapy. Methods: The retrospective study was conducted by reviewing 53 medical files of advanced NSCLC patients treated with platinum/gemcitabine at the University Clinic Golnik between May 2004 and November 2008. The median age of patients was 65 years, most of them were males (75 %), smokers or ex-smokers (81 %), with performance status 1 ( 64.2 %) and stage IV disease (83 %). The collected data included laboratory characteristics (Hb, platelet count, CRP, LDH) before chemotherapy, information on each individual patientćs therapy and outcome. The median number of chemotherapy cycles received was 4 (range, 1-6). Results: The medianprogression free survival (PFS) for the entire group was 4.8 months (range 0.20 months). Patients with elevated CRP levels (. 20 mg/l) had inferior PFS compared to those with low pretreatment CRP values (median PFS 8.4 vs 3.6 months, p=0.006). In Cox univariate regression analysis, CRP (p=0.016, HR=1.008, 95 %CI, 1.001.1.014), Hb (p=0.001, HR= 0.96, 95 %CI, 0.95.0.99), and comorbidity (p=0.051, HR=1.2, 95 %CI, 1.00 -1.45) were found to be significant prognostic factors; age, LDH, and platelet count on the other hand were not found to be significant prognostic factors. In multivariate analysis only CRP (p=0.048, HR=0.50, 95 %CI 0.26.0.99) and Hb (p=0.005, HR=0.97, 95 %CI, 0.95 -0.99) retained their independent prognostic value. (Abstract truncated at 2000 characters)Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, št. 10, 2010, str. 669-676)Vrsta gradiva - članek, sestavni delLeto - 2010Jezik - angleškiCOBISS.SI-ID - 27496409
Avtor
Ovčariček, Tanja |
Triller, Nadja |
Sadikov, Aleksander, računalništvo |
Čufer, Tanja, 1955-
Teme
Lung Neoplasms |
Drug Therapy |
Carcinoma, Non-Small-Cell Lung |
C-Reactive Protein |
Hemoglobins |
Survival Analysis |
Retrospective Studies |
Preživetje, analiza |
Karcinom nemalocelični, pljučni |
Hemoglobini |
Pljučne novotvorbe |
C-reaktivna beljakovina |
Retrospektivne študije
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vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, št. 10, 2010, str. 669-676)
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Ovčariček, Tanja | 54060 |
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Sadikov, Aleksander, računalništvo | 20389 |
Čufer, Tanja, 1955- | 12179 |
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