We investigated the psychological impact of the COVID-19 outbreak in terms of stress, anxiety, depression, sleep quality and affecting factors on healthcare workers (HWs) without secondary trauma ...thus far in the period between the first cases in Turkey and the arrival of the first case in ahospital. This descriptive cross-sectional study included 169 HWs. We used Impact of Event Scale (IES-R), Depression Anxiety Stress Scale and Pittsburgh Sleep Quality Index (PSQI) for assessment. The mean age of HWs was 33.9±6.9 years and 56.2% were males. Of the HWs; 20.7% were nurses, 33.7% doctors and 45.6% staff members. IES-R classified the HWs as follows: 15.4% of them were affected mildly, 4.7% moderately and 9.5% of them were affected severely. 42.6% of HWs had apoor sleep quality. This study shows that how HWs were affected when the outbreak had not yet reached the hospital in which they work. In total, 29.6% of the HWs were psychologically affected by mild to severe levels from the outbreak in this period. The most prevalent psychological impact was poor sleep quality. Psychological impact on HWs may have begun before the outbreak reached the hospitals; therefore, necessary measures should be taken as early as possible.
In this study, we aimed to investigate the sociodemographic characteristics of the individuals who mandated to the probation unit as the substances they use, their compliance with the programs, ...treatment outcomes and the relationships between these parameters. Secondly we aimed to determine the predictive factors that guide in taking protective measures.
The files of the individuals who applied to probation clinic of Gaziantep 25 Aralik State Hospital between 01.01.2019-31.12.2019 were examined retrospectively. SPSS 22.0 program was used to statistical analysis.
Totally 1024 cases were included in the study. Most of the cases were between the ages of 16-35 (84.1%) and 68.3% of individuals were primary school graduates. Most (n: 607, 59.3%) were single in terms of marital status. Substance was detected in the urine of 30.3% of the applicants (n: 311). Among the substances detected in urine, amphetamine-methamphetamine was in the first place with 13.6%. In terms of treatment compliance levels of probation, it was seen that 593 (57.9%) reports were prepared as "no treatment required", 117 (11.4%) were "compliant to treatment" and 303 (29.6%) were "noncompliant to treatment". A statistically significant difference was found between working status and treatment outcomes (p = 0.001). When the first urine result of the patients were grouped as negative and positive; A statistically significant difference was found between the first urine test and the treatment outcomes and criminal score (for both p = 0.001).There was a statistically significant difference between the status of being a probation measure previously and the outcome of treatment (p = 0.019).
In our study, the most used substance type was found to be amphetamine-methamphetamine (13.6%). Prevalence in substance use appears to be changing. This is an important finding about the prevalence of use of amphetamine-methamphetamine in Turkey. We suggest that those who have irregular jobs in the probation process, those with substance metabolites detected in the first urine, and those who have previously had probation precautions may have a poor prognosis and that it may be more effective to apply to those profiles in a general program that includes social and occupational fields.
INTRODUCTION|Community Mental Health Centers (CMHC) were established to provide psychosocial support services for patients with severe mental disorders such as bipolar disorder, schizophrenia, ...unspecified schizophrenia spectrum and other psychotic disorder. The aim of our study was to determine the effects of participation frequency in a CMHC on insight, treatment adherence and functionality in severe mental disorders.¤METHODS|362 patients diagnosed with bipolar disorder and psychosis according to the DSM–5 criteria and treated in CMHC were included in this retrospective study. The participation frequency of patients benefited from CMHC services for a year was retrospectively screened. The patients had been evaluated with Clinical Global Impression Scale (CGI), Medication Adherence Rating Scale (MARS), Global Assessment of Functioning (GAF), and Schedule for Assessing the Three Components of Insight (SATCI), and Functional Remission of General Schizophrenia Scale (FROGS). Patients were divided into two groups as bipolar disorder and psychosis (schizophrenia, schizoaffective and USS&OPD).¤RESULTS|The patients had been participated in CMHC services in 6 different frequency groups: 68 (18.8%) once in six months, 62 (17.1%) once in three months, 68 (18.8%) once in two months, 98 (27.1%) once/twice a month, 34 (9.4%) once/twice a week, 32 (8.8%) three/four times a week, respectively. There were significant differences between GAF, CGI, SATCI, MARS, FROGS scores in terms of participation frequencies of psychosis group and there were significant differences between GAF, CGI, MARS scores in terms of participation frequencies of bipolar disorder group at the end of one year. ¤DISCUSSION AND CONCLUSION|In general, as the participation frequency increased, insight, treatment adherence and functionality increased. In addition to individual factors, our results will also contribute to determine the frequency of participation in CMHC.¤
Few studies have investigated the relationship between electroconvulsive therapy (ECT) and markers of nitrosative stress and oxidative DNA damage.
The aim of this study is to examine changes in ...nitrosative stress and oxidative DNA damage in patients with a depressive episode treated with ECT.
The current study included 48 patients with a depressive episode treated with ECT and 30 healthy control participants. First, the serum nitrosative stress markers of nitric oxide (NO*), nitric oxide synthase (NOS), and peroxynitrite (ONOO-) and the oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were compared between the study and control groups. These parameters were also compared pre- and post-treatment for the study group.
NO*, NOS, and ONOO- levels were significantly higher in patients with depressive disorder (DD) than in the control group. NO* and NOS levels significantly decreased in the ECT group after treatment while 8-OHdG levels significantly increased.
The study findings suggest that ECT may have reduced nitrosative stress levels while increasing oxidative DNA damage. More research is now needed to better understand the issue.
KEY POINTS
Nitrosative stress levels can increase in patients with depressive disorder.
Electroconvulsive therapy may reduce nitrosative stress while increasıng oxidative DNA damage.
These results suggest that nitrosative stress plays an important role in the mechanism of action of electroconvulsive therapy.
Amaç: Bu çalışmada obsesif kompulsif bozukluk (OKB) hastalarında ürik asit, albümin, total bilirubin ve gamma glutamil transferaz (GGT) gibi serumda ölçülebilen oksidatif stres ile ilişkili basit ...laboratuvar parametrelerini sağlıklı kontroller ile karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya Gaziantep Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri polikliniğinde DSM-5 kriterlerine göre OKB tanısı ile tedavi edilen hastalar alınmıştır. OKB tanısı konulan 117 hasta ve hasta grubu ile demografik veriler ile eşleşebilecek 80 kişi sağlıklı kontrol grubu olarak alındı. Hasta ve kontrol grubu serum ürik asit, albümin, total bilirubin ve GGT açısından karşılaştırıldı. Hastaların klinik özellikleri Yale Brown Obsesyon Kompulsiyon Ölçeği (Y-BOCS) ve Klinik Global İzlenim Şiddet Ölçeği (KGI-S) ile değerlendirildi.
Bulgular: Hasta grubu yaş ortalaması 36.68±13.06 iken kontrol grubunun 35.54±8.82’di. Total bilirubin düzeyine bakıldığında hasta grubunda 0.69±2.19 mg/dL ve kontrol grubunda 0.63±0.47 mg/dL olmakla birlikte gruplar arasında anlamlı farklılık vardı. GGT düzeyi hasta grubunda 22.85±15.80 U/L ve kontrol grubunda ise 19.29±11.52 U/L olmakla birlikte gruplar arasında anlamlı fark yoktu.
Sonuç: Hastalar bilirubin dışında doğal antioksidan açısından kontrollerden farklı değildi. Çalışmamızdaki bulgular OKB ile ürik asit, albümin ve GGT arasında nedensel bir ilişki olduğunu desteklememektedir.
Purpose: The aim of this stıudy was to examine easy laboratory parameters associated with oxidative stress that can be measured in serum such as uric acid, albumin, total biluribine and gamma glutamyl transferase (GGT) in patients with obsessive compulsive disorder (OCD) by comparing them with healthy controls.
Materials and Methods: 117 Patients who were diagnosed as OCD according to DSM-5 criteria and 80 healthy controls were included in the study. Patient and control groups were compared in terms of serum uric acid, albumin, total biluribine and GGT. Yale Brown Obsession Compulsion Scale and Clinical Global Impression Scale were used to assess clinical characteristics of the patients.
Results: The mean age of the patients was 36.68±13.06 years, while it was 35.54±8.82 in control group. Total biluribin levels was higher in patients (0.69±2.19 mg/dL) than controls (0.63±0.47 mg/dL). Although the GGT level was 22.85 ± 15.80 U / L in the patient group and 19.29 ± 11.52 U / L in the control group, there was no significant difference between the groups.
Conclusion: Patients did not differ from controls in terms of natural antioxidant, except bilirubin. The results do not support a causal relationship between OCD and uric acid, albumine and GGT.
Purpose
The number of studies conducted on the role of neuroinflammation in the etiopathogenesis of bipolar disorder has been increasing in recent years. The role of Galectin‐1, Galectin‐9, and ...YKL‐40, which are considered to play roles in neuroinflammation and the etiopathogenesis of bipolar disorder, and the relationship of these parameters with cognitive functions were investigated in the present study.
Method
Serum Galectin‐1, Galectin‐9, and YKL‐40 levels were measured with the ELISA Method in 64 bipolar euthymic patients and 64 healthy controls. The Stroop and trail‐making tests were administered to assess cognitive functions in all participants.
Results
Serum Galectin‐1, Galectin‐9, and YKL‐40 levels were statistically and significantly lower in the patient group when compared to the healthy control group. The scores of the Stroop test and trail‐making tests were statistically higher in the patient group than in the healthy control group. There was a weak and positive correlation between serum Galectin‐1, Galectin‐9, and YKL‐40 levels and cognitive performance in all participants.
Discussion and conclusion
Statistically significant low levels of serum Galectin‐1, Galectin‐9, and YKL‐40 detected in the patient group suggest that these parameters have important roles in neuroinflammation. The statistically higher Stroop and trail‐making test scores of the patient group compared to the control group indicates that the cognitive performance of the patient group was weaker. Also, the positive correlation between Galectin‐1, Galectin‐9, and YKL‐40 levels and cognitive performance suggests that these molecules may have a neuroprotective role. We think that the present study will contribute to this field where there is very limited data in the literature.
There are studies reporting that neuroinflammation plays a role in the etiopathogenesis of bipolar disorder. We examined molecules associated with inflammation that have not been studied before in bipolar disorder and their relationship with cognition.
Abstract Objective Proline has an important role in the brain. Prolidase, a proline splitting enzyme, which is also involved in oxidative stress is not investigated in bipolar disorder (BD). Methods ...66 BD type I patients and 66 healthy controls were enrolled. Serum prolidase activity was measured in both groups via venous sampling. We have compared patients and controls as well as 3 subgroups of patients (24 euthymic, 22 manic, and 20 depressive patients). Results Prolidase activity was significantly higher in patients (p < 0.001, t = 14.517). There wasn't any significant difference among euthymic, manic and depressives (p = 0.305, f = 1.211). Positive predictive value was 98.5% and negative predictive value was 92.4% above the cutoff point 502.9375 U/L of prolidase activity. Conclusion Prolidase activity is impaired in BD, which may be associated with oxidative stress. Prolidase activity may be a trait marker for diagnosing bipolar disorder.
Aim: The purpose of this study was to investigate the rate of traumatic experiences and the relationship between traumas and anxiety, loneliness, depression, posttraumatic growth and pain, in refugee ...university students.
Materials and Methods: This study was conducted at the Gaziantep University between September 2017 and September 2018. UCLA (University of California, Los Angeles) Loneliness Scale, Posttraumatic Growth Inventory (PTGI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Traumatic Events Checklist (T.E.C) were used for assessment purposes.
Results: A total of 71 students were included in our study. There was a positive correlation between UCLA and BDI, T.E.C and a negative correlation between UCLA and PTGE. There was a positive correlation between BDI and BAI, T.E.C. A negative correlation was determined between PTGE and BDI and also T.E.C. A significant and positive correlation was observed between duration of pain felt during a day and T.E.C, BDI, and a negative correlation between duration of pain and PTGE.
Conclusion: Excessive traumatic experiences were positively related with depression and negatively related with traumatic growth. The duration of pain felt during a day was positively related with the excess of depressive symptoms and traumatic events, however there was no relationship between the presence of pain/localization of pain and assessment scales.
Amaç: Bu çalışmanın amacı, mülteci üniversite öğrencilerinde travmatik deneyimlerin oranını ve travmalar ile anksiyete, yalnızlık, depresyon, travma sonrası gelişim ve ağrı arasındaki ilişkiyi araştırmaktır. Gereç ve
Yöntemler: Bu çalışma Eylül 2017 ve Eylül 2018 tarihleri arasında Gaziantep Üniversitesi'nde gerçekleştirilmiştir. Değerlendirme için UCLA (California Üniversitesi, Los Angeles) Yalnızlık Ölçeği, Travma Sonrası Büyüme Envanteri (TSBE), Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE), Travmatik Yaşantilar Kontrol Listesi (TYKL) kullanılmıştır.
Bulgular: Çalışmaya toplam 71 öğrenci dahil edildi. UCLA ve BDE, TYKL arasında pozitif, UCLA ve TSBE arasında negatif korelasyon vardı. BDI, BAE ve TYKL arasında pozitif korelasyon vardı. TSBE ve BDE ile TYKL arasında negatif bir korelasyon saptandı. Bir gün içinde hissedilen ortalama ağrı süresi ile TYKL, BDE arasında anlamlı ve pozitif bir korelasyon ve ağrı süresi ile TSBE arasında negatif korelasyon gözlendi.
Sonuç: Mülteci öğrencilerde travmatik yaşantıların fazla olması depresyon ile pozitif, travmatik büyüme ile negatif ilişkiliydi. Gün içinde hissedilen ortalama ağrı süresi, depresif belirtilerin fazlalığı ve travmatik olayların fazlalılığı ile pozitif ilişkilidir, ancak ağrının varlığı / ağrının lokalizasyonu ve değerlendirme ölçekleri arasında bir ilişki saptanmamıştır.
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