The aim of this study was to investigate the contribution of skill training provided in a community mental health center to cognitive functions and activities of daily living of patients with ...schizophrenia, schizoaffective disorder or bipolar disorder. Our study included 39 patients, who regularly attended the skill training carried out in a community mental health center. The patients were administered the Montreal Cognitive Assessment (MoCA) test and the Lawton Instrumental Activities of Daily Living (IADL) scale at the beginning of the study and at the end of 6th month. A statistically significant increase was observed at the end of 6th-month scores of both scales compared to their baseline values. As a conclusion, the skill training help patients improve their cognitive functions and they are assumed to enable patients to perform their daily activities on their own by having a positive contribution to their activities of daily living and to help them become more active in their social relationships.
Amaç: Elektrokonvulsif terapinin (EKT) majör depresyonda etkinliği bilinmektedir. Bu çalışmada majör depresyonda EKT’nin total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi ...üzerindeki etkilerine bakılmıştır.
Gereç ve Yöntem: DSM-IV’e göre majör depresyon tanısı konulan 23 hasta ve 22 sağlıklı kontrol çalışmaya alındı. Hastalara sosyodemografik ve klinik bilgilendirme formu uygulandı. Hasta ve kontrollerden venöz kan örnekleri alındı. serum total antioksidan, total oksidan düzeylerine bakıldı.
Bulgular: Elektrokonvulzif terapi uygulaması öncesi hasta grubunda antioksidan seviye kontrol grubuna kıyasla daha düşük bulunmuştur. Hasta grubunda EKT uygulaması sonrası antioksidan seviye elektrokonvulzif terapi öncesine göre anlamlı düzeyde artmıştır. Elektrokonvulzif terapi uygulaması sonrası antioksidan seviye kontrol grubu ile kıyaslandığında anlamlı farklılık kalmamıştır. EKT öncesi ve sonrasında bakılan total oksidan seviye ve oksidatif stres indeksi açısından hasta ve kontrol grupları arasında anlamlı farklılık saptanmamıştır.
Sonuç: EKT uygulaması sonrasında hastalarda total antioksidan seviye düzeyinin artması, EKT’nin majör depresyon hastalarında antioksidan seviye artışına neden olduğunu düşündürmektedir.
Objective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with ...schizophrenia.
Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated.
Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p < .05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p = .01, p = .01, respectively), Positive and Negative Syndrome Scale-Negative scores (p = .002, p = .001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p = .03, p = .03, respectively), and Clinical Global Impression-Severity Scale scores (p = .008, p = .009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p = .032).
Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.
Abstract Diminished pain sensitivity or loss of pain sensation in schizophrenic patients has previously been reported. We report an interesting case of a schizophrenia patient who had the disease for ...20 years and who had his forearm amputated below the elbow level due to severe burn injury to his muscles, tendons, nerve fibers and bone tissue, caused by direct exposure to flames from a liquefied petroleum gas cylinder, in an attempt to make himself warm during a medicine-free period with active symptoms and without pain sensation.
Psychiatric disorders are common in obstructive sleep apnea syndrome (OSAS); however, interrelating factors influencing psychiatric comorbidity (PC) in OSAS are unclear. The aim of this study is to ...investigate gender related differences with PC in OSAS.
Data of patients diagnosed as OSAS in University of Gaziantep from January 2006 to January 2010 were retrospectively evaluated. Polysomnographic data were recorded with Viasys Sleep Screen (Viasys Healthcare, Germany). Patients younger than 18 years old were excluded.
PC was present in 53.1% of OSAS patients. The rate of male subjects with PC was 42.6%; however, 76.26% of females had PC (P = 0.00). Age (P = 0.00) and body mass index (BMI) (P = 0.00) were higher in patients with PC. Ferritin levels were lower in patients with PC (P = 0.00). Male subjects with PC were older and had lower sleep efficiency and longer rapid eye movement latency than males without PC. BMI was the only contributory factor to PC in female subjects.
PC in OSAS is common, especially in females. Apnea hypopnea index does not seem to influence probability of PC.
Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and ...schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism.
Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS.
TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups.
Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.
Abstract
Objective. Refugees have had major challenges to meet their health care needs throughout history especially in war zones and natural disaster times. The health care needs of Syrian refugees ...have been becoming an increasingly important issue. We aimed to examine the prevalence of post-traumatic stress disorder (PTSD) and explore its relation with various socioeconomic variables among Syrian refugees, who sought asylum in Turkey. Methods. This cross-sectional study was conducted in a tent city. Sample size calculation yielded 352 and the participants of the study were determined randomly. Experienced and native Arabic speaking, psychiatrist evaluated the participants. Results. The frequency of PTSD was 33.5%. Through the binary logistic regression analysis, we calculated that the probability of having PTSD among Syrian refugees in our sample was 71%, if they had the following features: with female gender; being diagnosed with psychiatric disorder in the past; having a family history of psychiatric disorder; and experiencing 2 or more traumas. Conclusions. The findings of our study suggest that PTSD among Syrian refugees in Turkey might be an important mental health issue in refugee camps especially among female refugees, who were exposed to 2 or more traumatic events and had a personal or family history of psychiatric disorder.
In our study, we aimed to examine Optical Coherence Tomography (OCT) findings in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls.
Sixty-five people ...were included in our study and 130 eyes were evaluated; 33 cases were included in the patient group with MUD according to DSM-5 diagnostic criteria and 32 as the healthy control group. Detailed biomicroscopic examinations and then both eyes were evaluated through OCT by the same ophthalmologist.
There was no statistically significant difference between the patient and control groups in terms of gender and age (p > 0.05). When the OCT findings were evaluated, the measurements of the patients in any quadrant for retinal nerve fiber layer (RNFL) were not statistically different from the control group (p > 0.05). Macula and choroidal layer thickness did not differ between the groups (p > 0.05). Only right intraocular pressure was found to be decreased in the patient group (p = 0.026).
There are a limited number of studies examining OCT findings in patients with MUD. Visual symptoms and intraocular pressure should be considered when evaluating patients with MUD and planning their treatment. In addition; in order for OCT findings to gain importance, which can be used as an effective method to show the possible neurodegeneration that may occur in substance use disorder, it should be supported with further research.
Abstract Background Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and ...Catalase (CAT) activities in BID. Methods 73 BID patients and 73 healthy controls were enrolled. Patients were classified into manic, depressive and euthymic state. Serum MPO and CAT were measured in both patients and controls. Results CAT activity was significantly lower in controls than manic, depressive and euthymics ( p <0.001). MPO activity was significantly higher in controls compared to euthymics ( p =0.007) and it was significantly higher in depressives compared to euthymics ( p =0.023). CAT was negatively and MPO was positively correlated with disease duration in overall the patients. Positive Predictive Value was 94.5% and Negative Predictive Value was 100% above the cutoff point for CAT activity. Conclusion MPO and CAT activities are impaired in BID, which may be associated with oxidative stress and inflammation.
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