A variety of oxides (titanium, tin, calcium, magnesium, and gallium) were supported over nano-crystalline ZSM-5 zeolite (n-ZSM-5) by wet impregnation, characterized and evaluated for propane ...dehydrogenation (PDH) reaction. To enhance the catalytic performance of the oxide-modified n-ZSM-5, Pt nanoparticles were also dispersed over the oxides-supported zeolite catalysts by wet impregnation. Finally, Ga-containing MFI zeolites were used as catalysts in the PDH. Ga was incorporated into the zeolite by two different methods, via hydrothermal synthesis and via wet impregnation. In the PDH reaction, Pt-containing samples exhibited a high initial catalytic activity although they suffered a fast deactivation by coke deposition. On the contrary, Ga-containing MFI catalysts showed a remarkable stability in the PDH reaction. In particular, the catalyst in which Ga was incorporated into the MFI structure by hydrothermal synthesis (Ga-MFI (nSH)) achieved the highest catalytic performance in PDH (9% conversion and 80% propylene selectivity) due to the synergy between the Brønsted and Lewis acid sites (BAS and LAS) and the optimal strength of its LAS sites. These results denote the great potential of Ga-MFI zeolites as catalysts in PDH reactions.
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•Various Pt and Ga-containing MFI zeolites were tested for propane dehydrogenation.•The effect of the concentration and strength of the BAS and LAS was analyzed.•Ga-containing MFI catalysts showed a superior stability than Pt-containing catalysts.•Synergy between BAS and LAS and the strong LAS improved the catalytic performance.
The recent global increase in the competitiveness of tourism has made the implementation of eco-innovations a differentiating element among both the destinations and companies in the sector, with ...quality management and contribution to sustainable development being increasingly valued. However, the eco-innovations that have been developed and implemented in tourist industries have rarely been studied. In this study, the eco-innovations that have been developed and implemented by 57 tourism businesses worldwide are analysed. The identified eco-innovations are classified by using different qualitative methodologies. The obtained results shed light on the limited development of eco-innovations in the tourism industry and the industry focuses mainly on product eco-innovations. Several examples by the tourist sub-industry and types of eco-innovation are analysed. Furthermore, this study provides practical information about measures that both businesses and governmental organisations can adopt to promote eco-innovation in the sector.
Bromo and extraterminal domain (BET) inhibitors-PROteolysis TArgeting Chimera (BETi-PROTAC) is a new family of compounds that induce proteasomal degradation through the ubiquitination of the tagged ...to BET inhibitors Bromodomain proteins, BRD2 and BRD. The encapsulation and controlled release of BET-PROTACs through their vectorization with antibodies, like trastuzumab, could facilitate their pharmacokinetic and efficacy profile. Antibody conjugated nanoparticles (ACNPs) using PROTACs have not been designed and evaluated. In this pioneer approach, the commercial MZ1 PROTAC was encapsulated into the FDA-approved polymeric nanoparticles. The nanoparticles were conjugated with trastuzumab to guide the delivery of MZ1 to breast tumoral cells that overexpress HER2. These ACNPs were characterized by means of size, polydispersity index, and Z-potential. Morphology of the nanoparticles, along with stability and release studies, completed the characterization. MZ1-loaded ACNPs showed a significant cytotoxic effect maintaining its mechanism of action and improving its therapeutic properties.
Although some researchers have recently studied green practices in restaurants, scant previous research has analyzed the impact of these practices on overall performance in this field. Moreover, ...these studies have generally focused on mega-sized restaurants in the United States. The primary objective of this study is therefore to examine the motivations for the adoption of green practices in restaurants in Spain and the impact of this adoption on firm performance. The results are based on a survey completed by 374 small restaurant managers. Structural equation modeling was used to analyze links between the studied dimensions. The findings indicate that green practices have a strong positive direct influence on operational performance and competitiveness in Spanish restaurants and that they indirectly influence overall firm performance. Therefore, the results of this paper suggest that being proactive about environmental issues can provide restaurants with a great number of benefits that improve firm competitiveness and performance.
Certified quality systems are progressively being adopted by all types of industries worldwide. This is due to the fact that many business organisations are actively seeking ways in which they can ...improve the products and services they offer. However, research has tended to focus on large manufacturing enterprises with a relative neglect of issues relating to quality certification among small-and-medium enterprises in the service sector. The present study addresses this relative gap in the literature by analysing the motives for, and impacts of, quality certification among both small- and medium-sized companies in the Spanish hotel industry. The study finds that significant differences exist with regard to quality certification between both size types in the hotel industry and previous studies based on large companies. The results highlight the importance that these enterprises grant to certified quality systems as a strategic tool that can be used in a proactive way to contend with market changes and adverse economic situations. Our findings have important implications for the management of small- and medium-sized enterprises.
This paper is driven both by a growing appetite for solo female travel; as well as a knowledge gap in the market and literature. The aim is to identify generational differences in women's solo travel ...motivations, characterize the generational differences in their preferred destination attributes, and ascertain any generational differences in their perceived inhibiting factors to travelling solo post the COVID-19 pandemic. By using the push-pull framework theory as the overarching framework, a survey was administered and 1576 responses from experienced solo female travellers were analysed. The findings revealed the different generations of solo female travellers and their distinctive travel needs (push factor/motivation, pull factor/destination preference, and inhibiting factors/risk & constraint) during the COVID pandemic.
The study reported the effect of granite sand on strength and microstructural developments in mortars prepare from OPC with a high coal fly ash (FA) content or from hybrid alkaline cements. The ...radiological behaviour of the resulting mortars was compared to materials prepared with siliceous sand (with particles sizes of <2 mm) and the relationship between such radiological findings and mortar microstructure and strength was explored. A new method for determining natural radionuclides and their activity concentration Index (ACI) on cement mortars (specifically to solid 5-cm cubic specimens) was applied and validated. The microstructural changes associated in mortars have no effect on mortar radiological content measurements. The mortars with granite sand exhibited very high ACI > 0.96, which would ultimately limit their use. A conclusion of interest is that where information is at hand on the starting materials (OPC, FA, sand, admixtures), their proportions in the mortar and the mixing liquid content (water or alkaline activators) their radiological content is accurately predicted. The inference is that a mortar’s radiological content and ACI can be known prior to mixing, providing a criterion for determining its viability. That in turn lowers environmental risks and the health hazards for people in contact with such materials.
Constitutional MLH1 epimutations are characterised by monoallelic methylation of the MLH1 promoter throughout normal tissues, accompanied by allele-specific silencing. The mechanism underlying ...primary MLH1 epimutations is currently unknown. The aim of this study was to perform an in-depth characterisation of constitutional MLH1 epimutations targeting the aberrantly methylated region around MLH1 and other genomic loci.
Twelve MLH1 epimutation carriers, 61 Lynch syndrome patients, and 41 healthy controls, were analysed by Infinium 450 K array. Targeted molecular techniques were used to characterise the MLH1 epimutation carriers and their inheritance pattern.
No nucleotide or structural variants were identified in-cis on the epimutated allele in 10 carriers, in which inter-generational methylation erasure was demonstrated in two, suggesting primary type of epimutation. CNVs outside the MLH1 locus were found in two cases. EPM2AIP1-MLH1 CpG island was identified as the sole differentially methylated region in MLH1 epimutation carriers compared to controls.
Primary constitutional MLH1 epimutations arise as a focal epigenetic event at the EPM2AIP1-MLH1 CpG island in the absence of cis-acting genetic variants. Further molecular characterisation is needed to elucidate the mechanistic basis of MLH1 epimutations and their heritability/reversibility.
Background
Fever‐7 is a test evaluating host mRNA expression levels of IFI27, JUP, LAX, HK3, TNIP1, GPAA1 and CTSB in blood able to detect viral infections. This test has been validated mostly in ...hospital settings. Here we have evaluated Fever‐7 to identify the presence of respiratory viral infections in a Community Health Center.
Methods
A prospective study was conducted in the “Servicio de Urgencias de Atención Primaria” in Salamanca, Spain. Patients with clinical signs of respiratory infection and at least one point in the National Early Warning Score were recruited. Fever‐7 mRNAs were profiled on a Nanostring nCounter® SPRINT instrument from blood collected upon patient enrolment. Viral diagnosis was performed on nasopharyngeal aspirates (NPAs) using the Biofire‐RP2 panel.
Results
A respiratory virus was detected in the NPAs of 66 of the 100 patients enrolled. Median National Early Warning Score was 7 in the group with no virus detected and 6.5 in the group with a respiratory viral infection (P > .05). The Fever‐7 score yielded an overall AUC of 0.81 to predict a positive viral syndromic test. The optimal operating point for the Fever‐7 score yielded a sensitivity of 82% with a specificity of 71%. Multivariate analysis showed that Fever‐7 was a robust marker of viral infection independently of age, sex, major comorbidities and disease severity at presentation (OR CI95%, 3.73 2.14‐6.51, P < .001).
Conclusions
Fever‐7 is a promising host immune mRNA signature for the early identification of a respiratory viral infection in the community.
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