The aim of this study was to investigate the frequency of alexithymia and attention deficit and to evaluate their relationship with the severity of disease in patients with fibromyalgia syndrome ...(FMS).
A total of 101 patients (6 males, 95 females; mean age 45.0 years; range, 33 to 56 years) who were admitted to Gaziantep University, Medical Faculty, Physical Medicine and Rehabilitation Department between January 2013 and December 2013 and were diagnosed with FMS and 40 healthy volunteers (4 males, 36 females; mean age 41.5 years; range, 31 to 51 years) were enrolled in this study. The Fibromyalgia Impact Questionnaire (FIQ), Hamilton Depression Scale (HAM-D), Toronto Alexithymia Scale-26 (TAS-26), and Jasper-Goldberg Attention Deficit Test (ADT) were applied.
The rate of alexithymia and possible alexithymia was 56.4% and 20.8% in the patients with FMS and 2.5% and 5% in the control group, respectively. The mean TAS-26 score was 60.1±11.7 in the patients with FMS. According to the HAM-D, depressive symptoms were seen in 72.0% and 2.5% of the patients with FMS and healthy controls, respectively.
Our study results confirm the presence of psychiatric comorbidities in patients with FMS and clearly suggest that depression, alexithymia, and attention deficit are high and mutually correlated in FMS patients. Therefore, all patients should be meticulously evaluated for these conditions at the treatment stage.
First-line drugs for obsessive-compulsive disorder (OCD) pharmacotherapy are selective serotonin reuptake inhibitors (SSRI). The medication must be continued for at least 12 weeks at an effective ...dosage to find the most effective SSRI. For treatment, the drug dose should be titrated to the highest tolerated dose. The manufacturer's recommended maximum dose of fluvoxamine is 300 mg per day. We reported remission after about 1 month of 600 mg (high dose) fluvoxamine, which was tolerated by a patient with OCD. The patient continued at this dose for 3 months and remained in remission.
The aim of this study was to investigate the contribution of skill training provided in a community mental health center to cognitive functions and activities of daily living of patients with ...schizophrenia, schizoaffective disorder or bipolar disorder. Our study included 39 patients, who regularly attended the skill training carried out in a community mental health center. The patients were administered the Montreal Cognitive Assessment (MoCA) test and the Lawton Instrumental Activities of Daily Living (IADL) scale at the beginning of the study and at the end of 6th month. A statistically significant increase was observed at the end of 6th-month scores of both scales compared to their baseline values. As a conclusion, the skill training help patients improve their cognitive functions and they are assumed to enable patients to perform their daily activities on their own by having a positive contribution to their activities of daily living and to help them become more active in their social relationships.
Aim: The purpose of this study was to investigate the rate of traumatic experiences and the relationship between traumas and anxiety, loneliness, depression, posttraumatic growth and pain, in refugee ...university students.
Materials and Methods: This study was conducted at the Gaziantep University between September 2017 and September 2018. UCLA (University of California, Los Angeles) Loneliness Scale, Posttraumatic Growth Inventory (PTGI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Traumatic Events Checklist (T.E.C) were used for assessment purposes.
Results: A total of 71 students were included in our study. There was a positive correlation between UCLA and BDI, T.E.C and a negative correlation between UCLA and PTGE. There was a positive correlation between BDI and BAI, T.E.C. A negative correlation was determined between PTGE and BDI and also T.E.C. A significant and positive correlation was observed between duration of pain felt during a day and T.E.C, BDI, and a negative correlation between duration of pain and PTGE.
Conclusion: Excessive traumatic experiences were positively related with depression and negatively related with traumatic growth. The duration of pain felt during a day was positively related with the excess of depressive symptoms and traumatic events, however there was no relationship between the presence of pain/localization of pain and assessment scales.
Amaç: Bu çalışmanın amacı, mülteci üniversite öğrencilerinde travmatik deneyimlerin oranını ve travmalar ile anksiyete, yalnızlık, depresyon, travma sonrası gelişim ve ağrı arasındaki ilişkiyi araştırmaktır. Gereç ve
Yöntemler: Bu çalışma Eylül 2017 ve Eylül 2018 tarihleri arasında Gaziantep Üniversitesi'nde gerçekleştirilmiştir. Değerlendirme için UCLA (California Üniversitesi, Los Angeles) Yalnızlık Ölçeği, Travma Sonrası Büyüme Envanteri (TSBE), Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE), Travmatik Yaşantilar Kontrol Listesi (TYKL) kullanılmıştır.
Bulgular: Çalışmaya toplam 71 öğrenci dahil edildi. UCLA ve BDE, TYKL arasında pozitif, UCLA ve TSBE arasında negatif korelasyon vardı. BDI, BAE ve TYKL arasında pozitif korelasyon vardı. TSBE ve BDE ile TYKL arasında negatif bir korelasyon saptandı. Bir gün içinde hissedilen ortalama ağrı süresi ile TYKL, BDE arasında anlamlı ve pozitif bir korelasyon ve ağrı süresi ile TSBE arasında negatif korelasyon gözlendi.
Sonuç: Mülteci öğrencilerde travmatik yaşantıların fazla olması depresyon ile pozitif, travmatik büyüme ile negatif ilişkiliydi. Gün içinde hissedilen ortalama ağrı süresi, depresif belirtilerin fazlalığı ve travmatik olayların fazlalılığı ile pozitif ilişkilidir, ancak ağrının varlığı / ağrının lokalizasyonu ve değerlendirme ölçekleri arasında bir ilişki saptanmamıştır.
Amaç: Elektrokonvulsif terapinin (EKT) majör depresyonda etkinliği bilinmektedir. Bu çalışmada majör depresyonda EKT’nin total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi ...üzerindeki etkilerine bakılmıştır.
Gereç ve Yöntem: DSM-IV’e göre majör depresyon tanısı konulan 23 hasta ve 22 sağlıklı kontrol çalışmaya alındı. Hastalara sosyodemografik ve klinik bilgilendirme formu uygulandı. Hasta ve kontrollerden venöz kan örnekleri alındı. serum total antioksidan, total oksidan düzeylerine bakıldı.
Bulgular: Elektrokonvulzif terapi uygulaması öncesi hasta grubunda antioksidan seviye kontrol grubuna kıyasla daha düşük bulunmuştur. Hasta grubunda EKT uygulaması sonrası antioksidan seviye elektrokonvulzif terapi öncesine göre anlamlı düzeyde artmıştır. Elektrokonvulzif terapi uygulaması sonrası antioksidan seviye kontrol grubu ile kıyaslandığında anlamlı farklılık kalmamıştır. EKT öncesi ve sonrasında bakılan total oksidan seviye ve oksidatif stres indeksi açısından hasta ve kontrol grupları arasında anlamlı farklılık saptanmamıştır.
Sonuç: EKT uygulaması sonrasında hastalarda total antioksidan seviye düzeyinin artması, EKT’nin majör depresyon hastalarında antioksidan seviye artışına neden olduğunu düşündürmektedir.
Purpose
The number of studies conducted on the role of neuroinflammation in the etiopathogenesis of bipolar disorder has been increasing in recent years. The role of Galectin‐1, Galectin‐9, and ...YKL‐40, which are considered to play roles in neuroinflammation and the etiopathogenesis of bipolar disorder, and the relationship of these parameters with cognitive functions were investigated in the present study.
Method
Serum Galectin‐1, Galectin‐9, and YKL‐40 levels were measured with the ELISA Method in 64 bipolar euthymic patients and 64 healthy controls. The Stroop and trail‐making tests were administered to assess cognitive functions in all participants.
Results
Serum Galectin‐1, Galectin‐9, and YKL‐40 levels were statistically and significantly lower in the patient group when compared to the healthy control group. The scores of the Stroop test and trail‐making tests were statistically higher in the patient group than in the healthy control group. There was a weak and positive correlation between serum Galectin‐1, Galectin‐9, and YKL‐40 levels and cognitive performance in all participants.
Discussion and conclusion
Statistically significant low levels of serum Galectin‐1, Galectin‐9, and YKL‐40 detected in the patient group suggest that these parameters have important roles in neuroinflammation. The statistically higher Stroop and trail‐making test scores of the patient group compared to the control group indicates that the cognitive performance of the patient group was weaker. Also, the positive correlation between Galectin‐1, Galectin‐9, and YKL‐40 levels and cognitive performance suggests that these molecules may have a neuroprotective role. We think that the present study will contribute to this field where there is very limited data in the literature.
There are studies reporting that neuroinflammation plays a role in the etiopathogenesis of bipolar disorder. We examined molecules associated with inflammation that have not been studied before in bipolar disorder and their relationship with cognition.
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