Polymer electrolytes are the subject of intensive study, in part because of their potential use as the electrolyte in all-solid-state rechargeable lithium batteries. These materials are formed by ...dissolving a salt (for example LiI) in a solid host polymer such as poly(ethylene oxide) (refs 2, 3, 4, 5, 6), and may be prepared as both crystalline and amorphous phases. Conductivity in polymer electrolytes has long been viewed as confined to the amorphous phase above the glass transition temperature, Tg, where polymer chain motion creates a dynamic, disordered environment that plays a critical role in facilitating ion transport. Here we show that, in contrast to this prevailing view, ionic conductivity in the static, ordered environment of the crystalline phase can be greater than that in the equivalent amorphous material above Tg. Moreover, we demonstrate that ion transport in crystalline polymer electrolytes can be dominated by the cations, whereas both ions are generally mobile in the amorphous phase. Restriction of mobility to the lithium cation is advantageous for battery applications. The realization that order can promote ion transport in polymers is interesting in the context of electronically conducting polymers, where crystallinity favours electron transport.
Optical properties of 4H-SiC were measured using time-domain and Fourier transform spectroscopy in the range of 0.1-20 THz. A high-transparency region was found between <0.1-10 THz. Based on the ...obtained data and published results, the refractive indices for o-wave and e-wave were approximated in the form of Sellmeier equations for the entire transparency range. Phase matched frequency conversion was found to be possible at wavelengths from the visible through the mid-IR and further into the far-IR (THz) region beyond 17 μm. Extremely low absorption coefficient, high damage threshold, and the possibility of phase matching make this material highly suited for high power THz optics and generation.
Activating receptor-tyrosine kinase rearranged during transfection
mutations and fusions are potent drivers of oncogenesis. The recent FDA approvals of highly potent and selective
inhibitors, ...selpercatinib and pralsetinib, has altered the therapeutic management of
aberrant tumors. There is ample evidence of the role of RET signaling in certain cancers. RET aberrations as fusions or mutations occur in multiple cancers, however, there is considerable phenotypic diversity. There is emerging data on the lack of responsiveness of immunotherapy in RET-altered cancers. Herein, we review the registrational data from the selective RET-inhibitor trials, and comprehensively explore
alterations in pan-cancer adult malignancies and their co-alterations. These co-occuring alterations may define the future of RET inhibition from specific selective targeting to customized combination therapies as data are rapidly emerging on both on-target and off-target acquired resistance mechanisms. Fascinatingly, oncogenic
fusions have been reported to mediate resistance to EGFR inhibition and KRAS
inhibition.
The multi-photon induced Fano effect Litvinenko, K L; Le, Nguyen H; Redlich, B ...
Nature communications,
01/2021, Letnik:
12, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The ordinary Fano effect occurs in many-electron atoms and requires an autoionizing state. With such a state, photo-ionization may proceed via pathways that interfere, and the characteristic ...asymmetric resonance structures appear in the continuum. Here we demonstrate that Fano structure may also be induced without need of auto-ionization, by dressing the continuum with an ordinary bound state in any atom by a coupling laser. Using multi-photon processes gives complete, ultra-fast control over the interference. We show that a line-shape index q near unity (maximum asymmetry) may be produced in hydrogenic silicon donors with a relatively weak beam. Since the Fano lineshape has both constructive and destructive interference, the laser control opens the possibility of state-selective detection with enhancement on one side of resonance and invisibility on the other. We discuss a variety of atomic and molecular spectroscopies, and in the case of silicon donors we provide a calculation for a qubit readout application.
To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling malignant, ...immune, stromal, and endothelial cells. Malignant cells within the same tumor displayed transcriptional heterogeneity associated with the cell cycle, spatial context, and a drug-resistance program. In particular, all tumors harbored malignant cells from two distinct transcriptional cell states, such that tumors characterized by high levels of the MITF transcription factor also contained cells with low MITF and elevated levels of the AXL kinase. Single-cell analyses suggested distinct tumor microenvironmental patterns, including cell-to-cell interactions. Analysis of tumor-infiltrating T cells revealed exhaustion programs, their connection to T cell activation and clonal expansion, and their variability across patients. Overall, we begin to unravel the cellular ecosystem of tumors and how single-cell genomics offers insights with implications for both targeted and immune therapies.
The concept of bioeconomics covers all sectors of the economy, including agriculture, which supplies renewable resources: plants, animals, microorganisms and their processed products. The goal is a ...transition to an economy that is independent of fossil fuels and non-renewable resources. Agriculture and forestry, fisheries and aquaculture, as well as the conversion of biotechnological biomass and biological waste, are central to the multilateral new value chain. The processing industry uses renewable resources in various products, in particular, due to the industrial application of biotechnological and microbiological processes, especially in the chemical industry. This also applies to the food, woodworking, paper, construction, leather, and textile industries, as well as parts of the pharmaceutical and energy industries. Thus, the cyclic system and the storage of reusable waste are also included in the bioeconomic system. The aim of our study is to study the degree of development of sustainable value chains in bioeconomics.
PurposeThe receptor tyrosine kinase rearranged during transfection (RET) can be oncogenically activated by gene fusions or point mutations. Multikinase inhibitors such as cabozantinib, lenvatinib and ...vandetanib have demonstrated activity in RET-dependent malignancies, and selective RET inhibitors (Selpercatinib and Pralsetinib) are in clinical trials. However, the responsiveness of RET-dependent malignancies to immune checkpoint inhibitors (ICIs) is unknown. We compared the time to treatment discontinuation (TTD) for ICI versus non-ICI therapy in patients with malignancies harbouring activating RET mutations or fusions (RET+).MethodsA retrospective review of all RET+ patients who were referred to the phase I clinical trials programme at the University of Texas MD Anderson Cancer Center was conducted. TTD was estimated using Kaplan-Meier analysis. Multivariate analysis using the Cox proportional hazard model was performed to identify independent risk factors of treatment discontinuation.ResultsOf 70 patients who received systemic therapy for RET+ malignancies, 20 (28.6%) received ICI and 50 (71.4%) received non-ICI therapy. Non-ICI therapy was associated with decreased risk for treatment discontinuation compared with ICI in the overall population (HR=0.31; 95% CI 0.16–0.62; p=0.000834) and in patients with RET point mutations (HR=0.13; 95% CI 0.04–0.45; p=0.00134). In patients with RET fusions, non-ICI therapy was associated with a non-statistically significant decreased risk of treatment discontinuation (HR=0.59; 95% CI 0.25–1.4; p=0.24). ICI therapy and a diagnosis other than medullary thyroid cancer (MTC) were independent risk factors for treatment discontinuation.ConclusionOur study supports the prioritisation of non-ICI over ICI therapy in patients with RET+ tumours.
The article is devoted to the results of integrating the industrial Internet of things platform and industrial production into a digital environment. The architecture of a data collection system is ...shown and ready for its implementation on the PJSC Techpribor and the laboratory of ITMO University. Firstly, we prepared the methodology for modeling three-dimensional scenes and the methodology for generating equipment data models. These methodologies are for the Winnum Industrial Internet of Things (IIoT) platform. Secondly, we indicated the main stages of Winnum platform integration into the enterprise information system in the framework of the described methodology.
Method of improvement of piezoelectric vibration sensors' performance characteristics via optimization of the details' functional surfaces roughness is presented in this paper. Effect of the ...functional surfaces roughness of the vibration sensor's details on the relative coefficient of transverse conversion has been studied. Description of the surfaces roughness has been fulfilled using graphical criteria. Optimum procedures and technological parameters of the mechanical treatment of the details' functional surfaces roughness providing the best relative coefficient of transverse conversion for the piezoelectric vibration sensor have been determined. Full-scale experiments pertinent to the surfaces mechanical treatment have been designed using Taguchi method, which allowed reducing substantially the number of the performed experiments.
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