The ArgoNeuT Collaboration presents the first measurements of inclusive muon neutrino charged current differential cross sections on argon. Obtained in the NuMI neutrino beam line at Fermilab, the ...flux-integrated results are reported in terms of outgoing muon angle and momentum. The data are consistent with the Monte Carlo expectation across the full range of kinematics sampled, 0°<θ(μ)<36° and 0<P(μ)<25 GeV/c. Along with confirming the viability of liquid argon time projection chamber technology for neutrino detection, the measurements allow tests of low-energy neutrino scattering models important for interpreting results from long baseline neutrino oscillation experiments designed to investigate CP violation and the orientation of the neutrino mass hierarchy.
A first dual-readout fibre calorimeter readout with Silicon Photomultipliers was designed, constructed and tested on beam. This first test completed the proof-of-concept and pointed out some issues ...to be address in future beam tests. Possible solutions and strategies to overcome these challenges are summarized in this paper.
To re-optimize the pneumococcal (Pn) electrochemiluminescence (ECL) assay and to validate and bridge the enhanced assay to the WHO ELISA, to support the Phase III clinical trial program for V114, a ...15-valent Pn conjugate vaccine.
The Pn ECL assay was re-optimized, validated and formally bridged to the WHO ELISA.
The enhanced Pn ECL assay met all prespecified validation acceptance criteria and demonstrated concordance with the WHO ELISA. The corresponding threshold value remains at 0.35 μg/ml for all 15 serotypes.
The enhanced Pn ECL assay has been validated for the measurement of antibodies to 15 Pn capsular polysaccharides and is concordant with the WHO ELISA, supporting its use in clinical trials.
Tests of a dual-readout fiber calorimeter with SiPM light sensors Antonello, M.; Caccia, M.; Cascella, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
08/2018, Letnik:
899, Številka:
C
Journal Article
Recenzirano
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In this paper, we describe the first tests of a dual-readout fiber calorimeter in which silicon photomultipliers are used to sense the (scintillation and Čerenkov) light signals. The main challenge ...in this detector is implementing a design that minimizes the optical crosstalk between the two types of fibers, which are located very close to each other and carry light signals that differ in intensity by about a factor of 60. The experimental data, which were obtained with beams of high-energy electrons and muons as well as in lab tests, illustrate to what extent this challenge was met. The Čerenkov light yield, a limiting factor for the energy resolution of this type of calorimeter, was measured to be about twice that of the previously tested configurations based on photomultiplier tubes. The lateral profiles of electromagnetic showers were measured on a scale of millimeters from the shower axis and significant differences were found between the profiles measured with the scintillating and the Čerenkov fibers.
The aim was to compare outcomes of self expanding PTFE covered stents (CSs) with bare metal stents (BMSs) in the treatment of iliac artery occlusions (IAOs).
Between January 2009 and December 2015, ...128 iliac arteries were stented for IAO. A CS was implanted in 78 iliac arteries (61%) and a BMS in 50 (49%). After propensity score matching, 94 limbs were selected and underwent stenting (47 for each group). Thirty day outcomes and midterm patency were compared; follow-up results were analysed with Kaplan–Meier curves.
Overall, iliac lesions were classified by limb as TASC B (19%), C (21%), and D (60%). Technical success was 98%. Comparing CS versus BMS, the early cumulative surgical complication rate (12% vs. 12%, p = 1.0) and 30 day mortality rate (2% vs. 2%, p = 1.0) were equivalent. At 36 months (average 23 ± 17), overall primary patency was similar between CS and BMS (87% vs. 66%, p = .06), and this finding was maintained after stratification by TASC B (p = .29) and C (p = .27), but for TASC D, CSs demonstrated a higher patency rate (CS, 88% vs. BMS, 54%; p = .03). In particular, patency was in favour of CSs for IAOs > 3.5 cm in length (p = .04), total lesion length > 6 cm (p = .04), and IAO with calcification > 75% of the arterial wall circumference (p = .01).
Overall, the use of self expanding CS for IAOs has similar early and midterm outcomes compared with BMS. Even if further confirmatory studies are needed, CSs seem to have higher midterm patency rates than BMSs for TASC D lesions, IAOs with a total lesion length > 6 cm, occlusion length > 3.5 cm, and calcification involving > 75% of the arterial wall circumference. These specific anatomical parameters may be useful to the operator when deciding between CS and BMS during endovascular planning.
The determination of wind‐induced fatigue load in large structures and buildings with complex geometries, which do not fall in typical cases of building codes and standards, represents a consuming ...task, and it is usually evaluated through the aid of wind tunnel tests, while computational approaches do not yet have a large application.
The practical use of computational fluid dynamics (CFD) techniques in civil engineering applications has in fact been rare outside the framework of steady‐state analyses, because of the limitations of RANS approaches and of the higher cost of LES, but with the increase in computing resources and with the introduction of new and more efficient turbulence models, the practical use of CFD to evaluate fluctuating features of wind flow is much more feasible now. With it, it is possible to foresee the possibility for the evaluation of wind‐induced fatigue loads in steel structures by using CFD. This paper has the purpose to discuss the feasibility of a procedure that uses CFD as the first step in a chain of numerical simulations that leads to the fatigue calculation of a large, complex structure.
The state of the art of turbulence models for CFD is here shown by performing literature review, with particular attention to their application to case studies related to large steel structures. A special focus in this paper lies in the use of PANS models, which reduce computational cost and grid sensitivity compared with LES, while providing comparable accuracy.
Future circular electron–positron colliders operating at s=90, 160, 240 and 350 GeV as Z, W, H and t factories will demand experiments with superior momentum and energy resolution for all the ...possible final-state particles produced. The IDEA Detector aims at satisfying these requests by exploiting an ultra-light drift chamber as the largest central tracker and a dual-readout fiber calorimeter for both electromagnetic and hadronic energy measurements. In this paper I review the dual-readout calorimeter baseline choices, as well as the related R&D work.
A human papillomavirus (HPV) multiplexed competitive Luminex immunoassay first described by Opalka et al. (D. Opalka, C. E. Lachman, S. A. MacMullen, K. U. Jansen, J. F. Smith, N. Chirmule, and M. T. ...Esser, Clin. Diagn. Lab. Immunol. 10:108--15, 2003) was optimized and validated for use in epidemiology studies and vaccine clinical trials. Optimization increased both the analytical sensitivity and the clinical specificity of the assay to more effectively discriminate the low-titer antibody response of HPV-infected persons from noninfected individuals. The characteristics of the assay that were optimized included monoclonal antibody (MAb) specificity, scaling up the conjugation of virus-like particles (VLPs) to microspheres, VLP concentration, MAb concentration, sample matrix, sample dilution, incubation time, heat inactivation of sample sera, and detergent effects on assay buffer. The assay was automated by use of a TECAN Genesis Workstation, thus improving assay throughput, reproducibility, and operator safety. Following optimization, the assay was validated using several distinct serum panels from individuals determined to be at low and high risk for HPV infection. The validated assay was then used to determine the clinical serostatus cutoff. This high-throughput assay has proven useful for performing epidemiology studies and evaluating the efficacy of prophylactic HPV vaccines.
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