Introducción: El envejecimiento es un fenómeno que ha aumentado a nivel mundial como consecuencia de una mayor esperanza de vida, evidenciando situaciones propias de esta etapa, que pueden impactar ...en la felicidad de los individuos, quienes merecen la atención y el abordaje desde la salud mental y la salud pública. Objetivo: explorar la asociación entre las características sociodemográficas, los antecedentes y síntomas médicos, el estado emocional, el apoyo social, el desempeño cognitivo y la dependencia funcional, con la felicidad en los adultos mayores de una zona rural de Túquerres, Nariño. Método: estudio transversal de asociación, con análisis de datos secundarios. Resultados: Se contó con 252 registros en total, correspondientes a los datos de los adultos mayores rurales. Se realizó una regresión lineal multivariable, encontrando asociación con la felicidad de las variables nivel socioeconómico (beta.sub.a = -.22; C95% -.58 - .13), nivel de escolaridad (beta.sub.a = .41; IC95% -.68 - 1.49), ocupación (beta.sub.a = .59; IC95% -.48 - 1.67), contar con enfermedad crónica (beta.sub.a = .42; IC95% .12 - .73), dificultades para respirar (beta.sub.a = -.25; IC95% -.51 - .02), presentar dolor en las coyunturas (beta.sub.a = .55; IC95% .26 - .83), presentar síntomas de depresión (beta.sub.a = -.21; IC95% -.48 - .06) o de ansiedad (beta.sub.a = .40; IC95% .72 - .07) y apoyo social (beta.sub.a = -.27; IC95% -.52 - -.02). Discusión: esta población cuenta con condiciones socioeconómicas y de salud desfavorables que impactan en su percepción de felicidad. Conclusión: La felicidad es un fenómeno multicausal que en los adultos mayores hace parte del resultado de la interacción de variables y decisiones históricas, a nivel político, económico y social.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 161 Mexicans from the state of Nayarit living in Tepic (N = 97) and rural communities (N = 64), to ...obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Nayarit include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nayarit are Native American (50.79 ± 5.03% by ML; 42.24% of Native American haplotypes) and European (37.04 ± 6.21% by ML; 35.72% of European haplotypes), while African genetic component is less apparent but relatively high (12.17 ± 2.50% by ML; 13.36% of African haplotypes).
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities ...(N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the state are Native American (52.74 ± 3.88% by ML; 48.10% of Native American haplotypes) and European (37.52 ± 8.94% by ML; 26.66% of European haplotypes), and a relatively high African genetic component (9.74 ± 8.40% by ML; 11.91% of African haplotypes).
•The present work assesses tree and energy characteristics of Gmelina arborea.•It was studied in three different spacings (0.5m, 1.0m and 2.0m).•Properties evaluated presented little variation due to ...spacing.•There is large variation between site, but scares between spacings.•The biomass produce by G. arborea is similar to other short-rotation energy crops.
Short-rotation woody plantations have been recently established in Costa Rica and Gmelina arborea has gained popularity The present work assesses tree diameter and height, biomass distribution, specific gravity, green density, moisture content, calorific value, ash content, volatile materials, carbon, nitrogen, extractives and production of energy in one-year-old short-rotation energy plantations of G. arborea in three different sites in Costa Rica, planted under three spacings (0.5×0.5m, 1.0×1.0m and 2.0×2.0m). The results showed that the properties evaluated presented little variation due to spacing. The variations by site and spacing in the properties of the biomass and its characteristics could be easily observed by multivariate analysis. According to this analysis, one site excelled with the best energy characteristics, while spacings of 0.5×0.5m and 1.0×1.0m show higher energy and biomass production in the three sites. Regarding the study of the characteristics and distribution of biomass in different parts of the tree, differences were found in initial moisture content, calorific value and volatile materials between the trunk, branches or bark. The highest percentage of biomass is concentrated in the trunk and branches. Finally, it was concluded that the species G. arborea produces similar amounts of biomass compared to other short-rotation energy crops.
Lanthanides have unique photoluminescence (PL) emission properties, including very long PL lifetimes. This makes them ideal for biological imaging applications, especially using PL lifetime imaging ...microscopy (PLIM). PLIM is an inherently multidimensional technique with exceptional advantages for quantitative biological imaging. Unfortunately, due to the required prolonged acquisitions times, photobleaching of lanthanide PL emission currently constitutes one of the main drawbacks of PLIM. In this study, we report a small aqueous‐soluble, lanthanide antenna, 8‐methoxy‐2‐oxo‐1,2,4,5‐tetrahydrocyclopentadequinoline‐3‐phosphonic acid, PAnt, specifically designed to dynamically interact with lanthanide ions, serving as exchangeable dye aimed at mitigating photobleaching in PLIM microscopy in cellulo. Thus, self‐assembled lanthanide complexes that may be photobleached during image acquisition are continuously replenished by intact lanthanide antennas from a large reservoir. Remarkably, our self‐assembled lanthanide complex clearly demonstrated a significant reduction of PL photobleaching when compared to well‐established lanthanide cryptates, used for bioimaging. This concept of exchangeable lanthanide antennas opens new possibilities for quantitative PLIM bioimaging.
We report a small aqueous‐soluble lanthanide antenna (PAnt) specifically designed to dynamically interact with lanthanide ions and act as an exchangeable dye, aiming at mitigating photobleaching in PLIM microscopy in cellulo. Our self‐assembled lanthanide complex exhibited an exceptional photostability compared to traditional lanthanide cryptates, marking a significant advance in quantitative PLIM bioimaging.
Introducing PAnt a significant advance in quantitative PLIM bioimaging: PAnt (“phosphonic acid antenna”) is a small water‐soluble lanthanide antenna tailored to dynamically self‐assemble with ...lanthanide ions, serving as exchangeable probe to overcome photobleaching in PLIM microscopy in cellulo. Lanthanide complexes that may be photobleached during acquisition are continuously replenished by intact PAnt antennas from a large reservoir, exhibiting remarkable photostability compared to traditional lanthanide cryptates, as reported by Angel Orte, Juan A. González‐Vera et al. in their Communication (e202314595). Artwork by M. Eugenio Vázquez, Univ. of Santiago de Compostela.
We performed a meta-analysis of diagnostic data to evaluate the performance of
Histoplasma
antigen detection tests for diagnosing histoplasmosis. We included all studies involving human subjects that ...assessed the performance of any antigen detection test for histoplasmosis in urine or serum by carrying out an exhaustive and reproducible search of the literature between 1980 and 2014 from four databases. Quality of the articles was assessed, and meta-analysis was performed under the random effects model, calculating sensitivity, specificity, likelihood and odds ratios, and ROC curve using
Meta
-
DiSc
(
es
). Nine out of a total of 23 studies met strict quality criteria and were therefore included. The overall sensitivity for antigen detection in serum and urine was 81 % (95 % CI 78–83 %), while specificity was 99 % (95 % CI 98–99 %). Sensitivity for antigenuria and antigenemia was 79 % (95 % CI 76–82 %) and 82 % (95 % CI 79–85 %), respectively; specificity values were 99 % (95 % CI 98–100 %) in urine and 97 % (95 % CI 96–98 %) in serum. The positive and negative likelihood ratios were 49.5 (95 % CI 20.7–118.7) and 0.19 (95 % CI 0.14–0.26), respectively, while the diagnostic OR was 362 (95 % CI 121.2–1080.3) and area under the curve was 0.99. In conclusion, the performance of
Histoplasma
antigen detection assay of urine was not significantly different from that of blood, indicating that antigenuria and antigenemia have equal diagnostic value in histoplasmosis.
Abstract
Background
The number of inpatients with alcohol and other substance-related problems (ASRP) in the general hospital population at any time is vast. To meet the needs of those patients, most ...hospitals have an Addiction Liaison Team (ALT) that diagnoses and initiates the treatment of the addictive disorder. In our hospital, this team is part of a more extensive and intensive Outpatient Alcoholism Treatment Programme that facilitates the continuity of care.
Aim
the main goal of this study is to evaluate the performance and effectiveness of our inpatient ALT.
Methodology
we carried out an observational cohort study of patients with ASRP admitted to the hospital from 2015 to 2017. We evaluated the performance and effectiveness of our ALT: referrals to the programme, inpatients mortality, readmissions to hospital, hospital length of stay (LOS) and medical or surgical treatment adherence.
Results
out of 133,181 admissions, 17,387 (13.14%) were positive for ASRP, and 615 (3.54%) were referred to the ALT. Referred patients had less in-hospital mortality, shorter LOS and lower risk of readmissions during the first year of follow-up. Subjects treated in the programme had better therapeutic adherence.
Conclusions
integrating the ALT into an outpatient programme facilitates an earlier detection and initiation of treatment during the hospital stay and the continuity of care. Alcohol misuse conditions affect the patient’s prognosis and health outcomes, so appropriate care is needed. Inclusion in the programme was associated with less risk of hospital mortality, fewer readmissions and a lower LOS.
Peptide engineering has gained attraction as a source of new cationicity-enhanced analogues with high potential for the design of next-generation antibiotics. In this context, cruzioseptin-1 (CZS-1), ...a peptide identified from
Cruziohyla calcarifer
, is recognized for its antimicrobial potency. However, this amidated-peptide is moderately hemolytic. In order to reduce toxicity and increase antimicrobial potency, 3 peptide analogues based on cruzioseptin-1 were designed and evaluated. K4K15CZS-1, an analogue with increased cationicity and reduced hydrophobicity, showed antibacterial, antifungal and antiproliferative properties. In addition, K4K15CZS-1 is less hemolytic than CZS-1. The in silico and scanning electron microscopy analysis reveal that K4K15CZS-1 induces a membranolytic effect on bacteria. Overall, these results confirm the potential of CZS-1 as source of inspiration for design new selective antimicrobial analogues useful for development of new therapeutic agents.
This study aims to detect the SARS-CoV-2 infection prevalence in asymptomatic pregnant women.
A group of 195 asymptomatic pregnant women who attended the prenatal care outclinic and to the obstetric ...emergency department was tested concomitantly for SARS-CoV-2 by RT-PCR and serological tests.
The virus was detected by RT-PCR in two (1.02%) cases and 17 (8.71%) patients had antibodies detected by immunochromatographic tests.
Due to the high risk of this emerging infection in the health of pregnant women, fetuses and newborns, we suggest the universal screening of all pregnant women admitted to hospital through the combined method RT-PCR and serological.
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