Data masses on the World Wide Web can hardly be managed by humans or machines. One option is the formal description and linking of data sources using Semantic Web and Linked Data technologies. ...Ontologies written in standardised languages foster the sharing and linking of data as they provide a means to formally define concepts and relations between these concepts. A second option is visualisation. The visual representation allows humans to perceive information more directly, using the highly developed visual sense. Relatively few efforts have been made on combining both options, although the formality and rich semantics of ontological data make it an ideal candidate for visualisation. Advanced visualisation design systems support the visualisation of tabular, typically statistical data. However, visualisations of ontological data still have to be created manually, since automated solutions are often limited to generic lists or node-link diagrams. Also, the semantics of ontological data are not exploited for guiding users through visualisation tasks. Finally, once a good visualisation setting has been created, it cannot easily be reused and shared. Trying to tackle these problems, we had to answer how to define composable and shareable mappings from ontological data to visual means and how to guide the visual mapping of ontological data.
We present an approach that allows for the guided visualisation of ontological data, the creation of effective graphics and the reuse of visualisation settings. Instead of generic graphics, we aim at tailor-made graphics, produced using the whole palette of visual means in a flexible, bottom-up approach. It not only allows for visualising ontologies, but uses ontologies to guide users when visualising data and to drive the visualisation process at various places: First, as a rich source of information on data characteristics, second, as a means to formally describe the vocabulary for building abstract graphics, and third, as a knowledge base of facts on visualisation. This is why we call our approach ontology-driven. We suggest generating an Abstract Visual Model (AVM) to represent and »synthesise« a graphic following a role-based approach, inspired by the one used by J. v. Engelhardt for the analysis of graphics. It consists of graphic objects and relations formalised in the Visualisation Ontology (VISO). A mappings model, based on the declarative RDFS/OWL Visualisation Language (RVL), determines a set of transformations from the domain data to the AVM. RVL allows for composable visual mappings that can be shared and reused across platforms. To guide the user, for example, we discourage the construction of mappings that are suboptimal according to an effectiveness ranking formalised in the fact base and suggest more effective mappings instead. The guidance process is flexible, since it is based on exchangeable rules. VISO, RVL and the AVM are additional contributions of this thesis. Further, we initially analysed the state of the art in visualisation and RDF-presentation comparing 10 approaches by 29 criteria. Our approach is unique because it combines ontology-driven guidance with composable visual mappings. Finally, we compare three prototypes covering the essential parts of our approach to show its feasibility. We show how the mapping process can be supported by tools displaying warning messages for non-optimal visual mappings, e.g., by considering relation characteristics such as »symmetry«. In a constructive evaluation, we challenge both the RVL language and the latest prototype trying to regenerate sketches of graphics we created manually during analysis. We demonstrate how graphics can be varied and complex mappings can be composed from simple ones. Two thirds of the sketches can be almost or completely specified and half of them can be almost or completely implemented.
Datenmassen im World Wide Web können kaum von Menschen oder Maschinen erfasst werden. Eine Option ist die formale Beschreibung und Verknüpfung von Datenquellen mit Semantic-Web- und Linked-Data-Technologien. Ontologien, in standardisierten Sprachen geschrieben, befördern das Teilen und Verknüpfen von Daten, da sie ein Mittel zur formalen Definition von Konzepten und Beziehungen zwischen diesen Konzepten darstellen. Eine zweite Option ist die Visualisierung. Die visuelle Repräsentation ermöglicht es dem Menschen, Informationen direkter wahrzunehmen, indem er seinen hochentwickelten Sehsinn verwendet. Relativ wenige Anstrengungen wurden unternommen, um beide Optionen zu kombinieren, obwohl die Formalität und die reichhaltige Semantik ontologische Daten zu einem idealen Kandidaten für die Visualisierung machen. Visualisierungsdesignsysteme unterstützen Nutzer bei der Visualisierung von tabellarischen, typischerweise statistischen Daten. Visualisierungen ontologischer Daten jedoch müssen noch manuell erstellt werden, da automatisierte Lösungen häufig auf generische Listendarstellungen oder Knoten-Kanten-Diagramme beschränkt sind. Auch die Semantik der ontologischen Daten wird nicht ausgenutzt, um Benutzer durch Visualisierungsaufgaben zu führen. Einmal erstellte Visualisierungseinstellungen können nicht einfach wiederverwendet und geteilt werden. Um diese Probleme zu lösen, mussten wir eine Antwort darauf finden, wie die Definition komponierbarer und wiederverwendbarer Abbildungen von ontologischen Daten auf visuelle Mittel geschehen könnte und wie Nutzer bei dieser Abbildung geführt werden könnten.
Wir stellen einen Ansatz vor, der die geführte Visualisierung von ontologischen Daten, die Erstellung effektiver Grafiken und die Wiederverwendung von Visualisierungseinstellungen ermöglicht. Statt auf generische Grafiken zielt der Ansatz auf maßgeschneiderte Grafiken ab, die mit der gesamten Palette visueller Mittel in einem flexiblen Bottom-Up-Ansatz erstellt werden. Er erlaubt nicht nur die Visualisierung von Ontologien, sondern verwendet auch Ontologien, um Benutzer bei der Visualisierung von Daten zu führen und den Visualisierungsprozess an verschiedenen Stellen zu steuern: Erstens als eine reichhaltige Informationsquelle zu Datencharakteristiken, zweitens als Mittel zur formalen Beschreibung des Vokabulars für den Aufbau von abstrakten Grafiken und drittens als Wissensbasis von Visualisierungsfakten. Deshalb nennen wir unseren Ansatz ontologie-getrieben. Wir schlagen vor, ein Abstract Visual Model (AVM) zu generieren, um eine Grafik rollenbasiert zu synthetisieren, angelehnt an einen Ansatz der von J. v. Engelhardt verwendet wird, um Grafiken zu analysieren. Das AVM besteht aus grafischen Objekten und Relationen, die in der Visualisation Ontology (VISO) formalisiert sind. Ein Mapping-Modell, das auf der deklarativen RDFS/OWL Visualisation Language (RVL) basiert, bestimmt eine Menge von Transformationen von den Quelldaten zum AVM. RVL ermöglicht zusammensetzbare »Mappings«, visuelle Abbildungen, die über Plattformen hinweg geteilt und wiederverwendet werden können. Um den Benutzer zu führen, bewerten wir Mappings anhand eines in der Faktenbasis formalisierten Effektivitätsrankings und schlagen ggf. effektivere Mappings vor. Der Beratungsprozess ist flexibel, da er auf austauschbaren Regeln basiert. VISO, RVL und das AVM sind weitere Beiträge dieser Arbeit. Darüber hinaus analysieren wir zunächst den Stand der Technik in der Visualisierung und RDF-Präsentation, indem wir 10 Ansätze nach 29 Kriterien vergleichen. Unser Ansatz ist einzigartig, da er eine ontologie-getriebene Nutzerführung mit komponierbaren visuellen Mappings vereint. Schließlich vergleichen wir drei Prototypen, welche die wesentlichen Teile unseres Ansatzes umsetzen, um seine Machbarkeit zu zeigen. Wir zeigen, wie der Mapping-Prozess durch Tools unterstützt werden kann, die Warnmeldungen für nicht optimale visuelle Abbildungen anzeigen, z. B. durch Berücksichtigung von Charakteristiken der Relationen wie »Symmetrie«. In einer konstruktiven Evaluation fordern wir sowohl die RVL-Sprache als auch den neuesten Prototyp heraus, indem wir versuchen Skizzen von Grafiken umzusetzen, die wir während der Analyse manuell erstellt haben. Wir zeigen, wie Grafiken variiert werden können und komplexe Mappings aus einfachen zusammengesetzt werden können. Zwei Drittel der Skizzen können fast vollständig oder vollständig spezifiziert werden und die Hälfte kann fast vollständig oder vollständig umgesetzt werden.
Abstract Objectives Oxidative stress in plasma may be promoted by plasma thiols such as homocysteine. However, other thiols such as glutathione may also exert antioxidant effects in vitro and in ...vivo. To further investigate whether plasma thiols act as prooxidants or antioxidants, we compared plasma oxidative status in patients with coronary heart disease (CHD) and in subjects occupationally exposed to carbon disulfide (CS2 ). Methods Fifty-five subjects chronically exposed to CS2 , 53 CHD patients, and 52 healthy controls were examined. To assess plasma oxidative status, concentrations of thiobarbituric reactive substances (TBARS) and total antioxidative capacity (TAC), as well as ferritin and ceruloplasmin were determined. Antioxidative reserve was assessed by the determination of vitamine E, uric acid, superoxide dismutase, catalase, and glutathion peroxidase. In addition, protein and non-protein plasma thiol levels were measured. Results Patients in both groups had increased levels of plasma thiols as compared to controls: CS2 -exposed subjects presented with increased levels of thiols associated with plasma proteins, whereas CHD patients presented with elevated total homocysteine and cysteine levels. TBARS were significantly increased and TAC was significantly decreased both in CS2 -exposed subjects and in CHD patients. In addition decreased activity of glutathione peroxidase, an antioxidative enzyme inhibited by thiol-containing compounds, was noted in both groups. Conclusion These results demonstrate that regardless of their metabolic origin increased thiols are associated with increased oxidative stress in plasma.
In this review, we discuss the use of continuous variable spectroscopy techniques for investigating quantum coherence and light-matter interactions in semiconductor systems with ultrafast dynamics. ...We focus on multichannel homodyne detection as a powerful tool to measure the quantum coherence and the full density matrix of a polariton system. By monitoring the temporal decay of quantum coherence in the polariton condensate, we observe coherence times exceeding the nanosecond scale. Our findings, supported by proof-of-concept experiments and numerical simulations, demonstrate the enhanced resourcefulness of the produced system states for modern quantum protocols. The combination of tailored resource quantifiers and ultrafast spectroscopy techniques presented here paves the way for future applications of quantum information technologies.
The first step in the splicing of an intron from nuclear precursors of mRNA results in the formation of a lariat structure. A distinct intronic nucleotide sequence, known as the branchpoint region, ...plays a central role in this process. We here describe a point mutation in such a sequence. Three sisters were shown to suffer from fish-eye disease (FED), a disorder which is caused by mutations in the gene coding for lecithin:cholesterol acyltransferase (LCAT). Sequencing of the LCAT gene of all three probands revealed compound heterozygosity for a missense mutation in exon 4 which is reported to underlie the FED phenotype, and a point mutation located in intron 4 (IVS4:T-22C). By performing in vitro expression of LCAT minigenes and reverse transcriptase PCR on mRNA isolated from leukocytes of the patient, this gene defect was shown to cause a null allele as the result of complete intron retention. In conclusion, we demonstrated that a point mutation in a lariat branchpoint consensus sequence causes a null allele in a patient with FED. In addition, our finding illustrates the importance of this sequence for normal human mRNA processing. Finally, this report provides a widely applicable strategy which ensures fast and effective screening for intronic defects that underlie differential gene expression.
1. Maculinea alcon, a myrmecophilic, stenotopic lycaenid butterfly is restricted to wet heathlands, bogs, and nutrient-poor hay meadows. Due to intensification of agriculture and decrease of ...extensively grazed meadows, many suitable habitats have disappeared and the remaining ones are highly fragmented and deteriorated. 2. Historical distribution data and a comparison with the present occupation of patches show the decline of this critically endangered butterfly in north-west Germany. Most of the populations in north-west Germany are small and often geographically isolated. 3. In summer 2002, two-thirds of 77 investigated potential patches were unoccupied as a result of unsuitable habitat structure and habitat fragmentation. 4. Several habitat parameters were highly significantly correlated with the presence of M. alcon, in particular the distribution pattern of the host plant Gentiana pneumonanthe. Furthermore, butterflies were absent from many patches with an incidence probability below 50% with respect to patch size and isolation. 5. In the nature reserve Lüneburger Heide, part of the study area, M. alcon populations have been observed since 1995. Typical turnover of local populations could be detected during these years. Extinctions and re-colonisations have stabilised the presence of this species in a metapopulation in this nature reserve. 6. These data show the importance of different factors on different spatial levels influencing the presence of this endangered butterfly.
Neue Herausforderungen im europäischen und deutschen Recht, neue Verfahrenskonzepte und neue Typen von Verwaltungsentscheidungen fordern Antworten im Verwaltungsverfahrensrecht. Der Band behandelt ...Verfahrensregeln, unterschiedliche Verfahrensschritte und deren Vernetzungen sowie das Zusammenspiel förmlicher und nicht förmlicher Verfahren. Zu bekannten Verfahrenstypen – wie Auswahl-, Zulassungs-, Planungs- und Überwachungsverfahren – treten neue hinzu, etwa Vergabe- und Versteigerungsverfahren, zur Auditierung sowie im Zuge europäischer Verwaltungskooperation. Die Beiträge behandeln das Spannungsverhältnis zwischen evolutionären Änderungen in der Rechtsdogmatik und der Kodifikation neuer Verfahrensformen und -typen. Sie sind Teil der nunmehr seit über zehn Jahren in dieser Schriftenreihe dokumentierten Bemühungen um eine Reform des Verwaltungsrechts. Sie analysieren Verwaltungsverfahren als Mittel der Artikulation und Abklärung von Interessen im Problemlösungsprozess, als Garanten der Richtigkeit zu treffender Entscheidungen, aber auch als Weg zur Vorverlagerung von Rechtsschutz.
We theoretically and experimentally investigate quantum features of an interacting light-matter system from a multidisciplinary perspective, unifying approaches from semiconductor physics, quantum ...optics, and quantum information science. To this end, we quantify the amount of quantum coherence that results from the quantum superposition of Fock states, constituting a measure of the resourcefulness of the produced state for modern quantum protocols. As an archetypal example of a hybrid light-matter interface, we study a polariton condensate and implement a numerical model to predict its properties. Our simulation is confirmed by our proof-of-concept experiment in which we measure and analyze the phase-space distributions of the emitted light. Specifically, we drive a polariton microcavity across the condensation threshold and observe the transition from an incoherent thermal state to a coherent state in the emission, thus confirming the build-up of quantum coherence in the condensate itself.
BACKGROUND: Community-based cohort studies are not available that evaluated the predictive power of both clinical and genetic risk factors for venous thromboembolism (VTE). There is, however, ...clinical need to forecast the likelihood of future occurrence of VTE, at least qualitatively, to support decisions about intensity of diagnostic or preventive measures. MATERIALS AND METHODS: A 10-year observation period of the Bavarian Thromboembolic Risk (BATER) study, a cohort study of 4337 women (18-55 years), was used to develop a predictive model of VTE based on clinical and genetic variables at baseline (1993). The objective was to prepare a probabilistic scheme that discriminates women with virtually no VTE risk from those at higher levels of absolute VTE risk in the foreseeable future. A multivariate analysis determined which variables at baseline were the best predictors of a future VTE event, provided a ranking according to the predictive power, and permitted to design a simple graphic scheme to assess the individual VTE risk using five predictor variables. RESULTS: Thirty-four new confirmed VTEs occurred during the observation period of over 32,000 women-years (WYs). A model was developed mainly based on clinical information (personal history of previous VTE and family history of VTE, age, BMI) and one composite genetic risk markers (combining Factor V Leiden and Prothrombin G20210A Mutation). Four levels of increasing VTE risk were arbitrarily defined to map the prevalence in the study population: No/low risk of VTE (61.3%), moderate risk (21.1%), high risk (6.0%), very high risk of future VTE (0.9%). In 10.6% of the population the risk assessment was not possible due to lacking VTE cases. The average incidence rates for VTE in these four levels were: 4.1, 12.3, 47.2, and 170.5 per 104 WYs for no, moderate, high, and very high risk, respectively. CONCLUSION: Our prognostic tool - containing clinical information (and if available also genetic data) - seems to be worthwhile testing in medical practice in order to confirm or refute the positive findings of this study. Our cohort study will be continued to include more VTE cases and to increase predictive value of the model.
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