(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image).An angular analysis of the decay B super(0) arrow right K super(*)(892) super(0) is reported based on a pp collision data ...sample, corresponding to an integrated luminosity of 1.0 fb super(-1), collected at a centre-of-mass energy of ... = 7 TeV with the LHCb detector. The P-wave amplitudes and phases are measured with a greater precision than by previous experiments, and confirm about equal amounts of longitudinal and transverse polarization. The S-wave K super(+) pi super(-) and K super(+) K super(-) contributions are taken into account and found to be significant. A comparison of the B super(0) arrow right K super(*)(892) super(0) and ... results shows no evidence for direct CP violation in the rate asymmetry, in the triple-product asymmetries or in the polarization amplitudes and phases. Figure not available: see fulltext.
(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image).The angular distributions of the rare decays B super(+) arrow right K super(+) mu super(+) mu super(-) and ... are studied ...with data corresponding to 3fb super(-1) of integrated luminosity, collected in proton-proton collisions at 7 and 8 TeV centre-of-mass energies with the LHCb detector. The angular distribution is described by two parameters, F sub(H) and the forward-backward asymmetry of the dimuon system A sub(FB), which are determined in bins of the dimuon mass squared. The parameter F sub(H) is a measure of the contribution from (pseudo)scalar and tensor amplitudes to the decay width. The measurements of A sub(FB) and F sub(H) reported here are the most precise to date and are compatible with predictions from the Standard Model. Figure not available: see fulltext.
Nitric oxide synthase isoform expression in acute versus chronic anti-Thy 1 nephritis.
Two inbred Lewis rat substrains (LEW/Moe, LEW/Maa) were identified responding differently to induction of ...anti-Thy 1 glomerulonephritis (aThy 1-GN). LEW/Moe rats show an acute mesangioproliferative glomerulonephritis with rapid healing of glomerular lesions within four weeks, while LEW/Maa rats develop severe glomerular injury followed by chronic glomerular sclerosis and persistent albuminuria. We investigated whether the glomerular expression pattern of nitric oxide synthase (NOS) isoforms could explain these substrain-related differences.
Rats (N = 5 to 7 per group) were investigated in a time course experiment. Severity of aThy 1-GN was determined by albuminuria measurements, glomerular matrix score and microaneurysm formation. Glomerular gene expression of NOS isoforms was determined by semiquantitative RT-PCR. Inducible NOS (iNOS) activity was determined in cultured glomeruli and peritoneal macrophages. Neuronal NOS (nNOS) protein expression was detected by Western blotting and enzyme histochemistry. Plasma renin activity (PRA) was measured by RIA.
Induction of iNOS expression and activity was found significantly increased and sustained in LEW/Maa vs. LEW/Moe rats associated with an increased number of infiltrating macrophages and with an increased capacity of iNOS-expression and iNOS-activation by isolated macrophages in LEW/Maa rats. Glomerular nNOS mRNA and nNOS protein expression were constitutively increased in LEW/Maa rats. Renal nNOS localization was restricted to the macula densa region in both substrains and associated with increased PRA in LEW/Maa rats. No difference in glomerular endothelial NOS-mRNA expression between the substrains was observed.
Increased glomerular iNOS and nNOS expression were associated with chronic anti-Thy 1 glomerulonephritis in LEW/Maa rats and may contribute to glomerular damage by separate mechanisms.
(ProQuest: ... denotes formulae and/or non-USASCII text omitted; see image).Measurements of b-hadron lifetimes are reported using pp collision data, corresponding to an integrated luminosity of 1.0 ...fb super(-1), collected by the LHCb detector at a centre-of-mass energy of 7 TeV. Using the exclusive decays B super(+) arrow right J/ psi K super(+), B super(0) arrow right J/ psi K super()(892) super(0), ..., ... and ... the average decay times in these modes are measured to be ...where the first uncertainty is statistical and the second is systematic. These represent the most precise lifetime measurements in these decay modes. In addition, ratios of these lifetimes, and the ratio of the decay-width difference, Delta Gamma sub( )d to the average width, Gamma sub( )d in the B super(0) system, Delta Gamma sub( )d/ Gamma sub( )d= -0.044 plus or minus 0.025 plus or minus 0.011, are reported. All quantities are found to be consistent with Standard Model expectations. Figure not available: see fulltext.
Se evaluó 205 casos de muerte materna ocurridas en el Hospital Maternidad de Lima en el último quinquenio 1980-1984, lapso en el que hubo 154,131 partos, lo que da una tasa de mortalidad materna de ...9.3 por 10,000 nacidos vivos. La muerte ocurrió en el 12% en adolescentes y en el 29% en mujeres mayores de 35 años, en nulíparas 20% y grandes multíparas 34%. La principal causa directa de muerte la constituyeron, la infección (34%), principalmente por aborto séptico y endometritis, la toxemia (22%) y la hemorragia (16%), causas indirectas la T. B. C., cardiopatías, embolia pulmonar, mola y coriocarcinoma, totalizando 22%.
In essential hypertension, stroke and kidney damage may result from an impaired interaction of vasoregulatory systems. Stroke-prone spontaneously hypertensive rats (SHRSP) were studied to analyze the ...effects of a low-dose treatment of the angiotensin II type 1 receptor (AT1) blocker candesartan cilexetil on the expression of nitric oxide synthases (NOS) and on vascular structure. Both treated and untreated SHRSP were kept on a stroke-promoting dietary regimen, and compared with Wistar Kyoto rats (WKY). Early mortality of untreated SHRSP was prevented by the treatment. In untreated SHRSP, cerebral intraparenchymal vessels of the parietal lobe showed lesions of the vascular wall and its periphery, such as proteinaceous deposits, perivascular dilated spaces, increase in phagocytic cells, and decreased actin immunostaining. Renal lesions were more pronounced comprising arteriolar occlusion, extensive loss of actin, increased alpha1(IV) collagen expression, and glomerular sclerotic as well as tubulointerstitial lesions. Beneficial effects of the AT1 blockade were more pronounced in brain than in kidney. Activity profile of NOS showed increased NADPH diaphorase staining in media and endothelium of SHRSP; endothelial NOS3 immunoreactivity was decreased, but instead, inducible NOS2 increased in untreated SHRSP. These changes were largely prevented in the treated group. NOS activity in macula densa cells was unchanged, whereas afferent arteriolar renin levels were increased in untreated SHRSP. Results demonstrate an effective reduction of hypertensive vascular changes with a nonpressor dose of candesartan. A "role switch" of vascular NOS in hypertension from physiologic NOS3 toward deleterious NOS2 is suggested, and its prevention by the AT1 blocker points to an angiotensin II-dependent, nitric oxide-mediated pathway that may impair endothelial function and aggravate defects of the blood-brain barrier and kidney structures.
A monoclonal antibody against an antigen (PCD2) derived from the rabbit renal papilla recognized principal and intercalated cells of the collecting duct system in the adult rabbit kidney. ...Intercalated cells were heterogeneous in the connecting tubule and the cortical collecting duct, where immunoreactive and unreactive cells were shown to coexist. In the outer medullary collecting duct, all intercalated cells exhibited PCD2-immunoreactivity. Connecting tubule cells proper were not recognized by the antibody, whereas all principal cells of the collecting duct revealed specific immunoreactivity. The immunocytochemical heterogeneity of the intercalated cells is discussed in terms of a functional heterogeneity. Cytologically, the immunogold labeling of principal and intercalated cells was shown to occur along the plasmalemma, in the intracellular membrane structures and along the Golgi transport route. This pattern suggests that the antigenic determinant, which is ubiquitous in both principal and reactive intercalated cells, belongs to a membrane protein.
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