Abstract Thymic tumors are epithelial tumors of the thymus for which multimodal therapies are often ineffective because of a lack of standardized regimens. Due to the low incidence, the molecular ...pathology and genomic abnormalities of thymic epithelial tumors are largely unknown. In this study, we report our comprehensively genomic study on a case of metastatic thymic tumor. Using next generation deep DNA sequencing technology, we sequenced 190 segments of 46 cancer genes of the cancer genome to cover 739 COSMIC mutations in 604 loci. Among these sequenced cancer genes, we identified that three low frequency (~10% of cells) mutations in the TP53 gene (c.782+1G > T), ALK gene (c.3551C > T), and RET gene (c.2651A > T). To the best of our knowledge, this is the first study to show those mutations in thymic tumor. Of note, our study further indicates comprehensive molecular analysis may facilitate development of novel diagnostic and therapeutic strategies for thymic tumors.
We investigate finite-time synchronization (FTS) of multiweighted and directed complex-valued networks (MWDCVNs), which is denoted by complex-valued ordinary differential equations. We divide ...complex-valued error system into real and imaginary part separately. For each part, we use two methods. One method is rearranging variables' order technique (ROT). The other method is Kronecker order technique (KOT). Besides, we study cooperative and competitive relationships both in inner and outer coupling terms, while few papers have considered competitive relationship. Corresponding numerical experiments confirm the validity of our theories.
Hybrid Wireless Power Transfer (HWPT) can effectively utilise the respective advantages of electric-field coupled and magnetic-field coupled systems, and has received attention and research from ...scholars in various countries in recent years. This paper is based on a new bilateral CL-compensated HWPT system, considering the edge effect of the capacitive coupler and the temperature effect of the inductive coupler of the system, and analyses the multi-physical domains of electric field, magnetic field and temperature field of the system using Ansys Workbench and Maxwell. And the combination of optimised design of the coupler structure of the HWPT system is further realised through technical measures such as the addition of equipotential protection ring plate, heat pipe heat sink and optimisation of the coupling coil parameters, in order to improve the transfer power and transfer distance of this system, which provides a feasible strategy for the optimised design of the HWPT system.
For researching the strong earthquake recurrence period of Kusai Lake and Xidatan fault segment in different sliding velocities, we apply the spring-block model (or BK model) controlled by the ...velocity and state depended frictional constitutive. Through numerically solving the one order differential equations picturing the block (or fault segment) motion, the parameter charactering the fault segment motion is achieved. Finally, we find the recurrence period of strong earthquake is shorter in fast sliding velocity than that in slow one. The 0.1 mm changing of fault segment sliding velocity per year will make the several hundreds years of variation in strong earthquake recurrence period.
Mechanical Resonance commonly happens in servo system due to the elastic connection between transmission shafts. The Two-Mass Mathematical Model is established in order to explore the theoretical ...cause of mechanical resonance. After comparing several typical signals mostly used before, a novel excitation signal for the vibration test is proposed in this paper-the Pseudo-Random-Binary Sequences (PRBS) signal, which is able to fully motivate the system performance, thus accurately positioning resonance frequency. Then the detected resonance frequency can be used to determine the parameters of notch filter, which is selected for vibration suppression. The whole course of vibration detection and suppression is based on Labview platform, where graphical programming is conducted, together with data collection, spectrum analysis, and instruction transfer so as to manipulate real-time system to suppress the vibration.
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