The quantum perceptron is a fundamental building block for quantum machine learning. This is a multidisciplinary field that incorporates abilities of quantum computing, such as state superposition ...and entanglement, to classical machine learning schemes. Motivated by the techniques of shortcuts to adiabaticity, we propose a speed-up quantum perceptron where a control field on the perceptron is inversely engineered leading to a rapid nonlinear response with a sigmoid activation function. This results in faster overall perceptron performance compared to quasi-adiabatic protocols, as well as in enhanced robustness against imperfections in the controls.
Women with breast cancer are prone to have mental stress and be stimulated by the fear of progression (FOP), then giving rise to a lower quality of life (QOL). The study aimed to examine the ...relationships between FOP, social support and QOL, and further explore whether social support mediates the association between FOP and QOL among Chinese patients with breast cancer. The cross-sectional study was conducted from October 2019 to May 2020 at Anshan Cancer Hospital in Liaoning, China. 244 female breast cancer patients completed questionnaires including the Functional Assessment of Cancer Therapy for Breast (FACT-B), Multi-Dimensional Scale of Perceived Social Support (MSPSS), and Fear of Progression (FOP). Hierarchical multiple regression analysis was performed to assess the associations between FOP, social support and QOL. Asymptotic and resampling strategies were used to explore the mediating role of social support. The mean QOL score was 90.6 + or - 17.0 among the patients with breast cancer. FOP was negatively correlated with QOL, while social support was positively related to QOL. Social support partly mediated the association between FOP and QOL, and the proportion of the mediating effect accounted for by social support was 25%. Chinese breast cancer patients expressed low QOL. Social support could mediate the association between FOP and QOL. Medical staffs and cancer caregivers should alleviate patients' FOP to improve their QOL by facilitating social support.
Marine mangrove vegetation has been traditionally employed in folk medicine to address various ailments. Notably,
Blume has exhibited noteworthy properties, demonstrating efficacy against cancer, ...viruses, and bacteria. The enzyme fatty acid synthase (FAS) plays a pivotal role in de novo fatty acid synthesis, making it a promising target for combating colon cancer. Our study focused on evaluating the FAS inhibitory effects of both the crude extract and three isolated compounds from
. The n-butanol fraction of
extract (BFR) demonstrated a significant inhibition of FAS, with an IC
value of 93.0 µg/mL. For inhibition via lyoniresinol-3α-
-β-rhamnopyranoside (LR), the corresponding IC
value was 20.1 µg/mL (35.5 µM). LR competitively inhibited the FAS reaction with acetyl-CoA, noncompetitively with malonyl-CoA, and in a mixed manner with NADPH. Our results also suggest that both BFR and LR reversibly bind to the KR domain of FAS, hindering the reduction of saturated acyl groups in fatty acid synthesis. Furthermore, BFR and LR displayed time-dependent inhibition for FAS, with k
values of 0.0045 min
and 0.026 min
, respectively. LR also exhibited time-dependent inhibition on the KR domain, with a k
value of 0.019 min
. In human colon cancer cells, LR demonstrated the ability to reduce viability and inhibit intracellular FAS activity. Notably, the effects of LR on human colon cancer cells could be reversed with the end product of FAS-catalyzed chemical reactions, affirming the specificity of LR on FAS. These findings underscore the potential of BFR and LR as potent FAS inhibitors, presenting novel avenues for the treatment of human colon cancer.
We propose quantum neural networks that include multi-qubit interactions in the neural potential leading to a reduction of the network depth without losing approximative power. We show that the ...presence of multi-qubit potentials in the quantum perceptrons enables more efficient information processing tasks such as XOR gate implementation and prime numbers search, while it also provides a depth reduction to construct distinct entangling quantum gates like CNOT, Toffoli, and Fredkin. This simplification in the network architecture paves the way to address the connectivity challenge to scale up a quantum neural network while facilitating its training.
We report late Oligocene to late Pliocene micromammal assemblages from 19 localities of the Linxia Basin of Gansu Province, China. Abundant material (> 7000 specimens) includes members of ...Eulipotyphla, Chiroptera, Rodentia and Lagomorpha, and comprises 121 species arranged in 24 families. The Yagou assemblage (basal part of the Jiaozigou Formation) is one of the few early Late Oligocene micromammalian faunas known from China. The Galijia (Dongxiang Formation) and Yihachi (“Liushu” Formation) assemblages represent the richest and most productive middle and late Miocene micromammal faunas known from northwestern China. These middle Cenozoic faunas show a closely similar community structure and taxonomic composition, and a similar pattern of faunal turnover, with contemporary faunas throughout the Mongol-Xinjiang Region, implying the existence of a unified biogeographic zone. The discoveries contribute to the temporal ordering of individual fossil assemblages of northern China and help develop a framework for Cenozoic biostratigraphy and biochronology in central Asia. Our palaeoenvironmental analysis suggests change towards warmer and moister equable habitats of the late Oligocene to early and middle Miocene, followed by the onset of drier temperate shrub-steppe environments. The composition of extant families of micromammals that developed during the Neogene reflects a faunal distribution analogous to the Holarctic Region today and suggests a shared ecology.
•Galijia and Yihachi are the richest Miocene small mammal sites of NW China.•Turnover followed Oligocene closure of the Turgai Strait.•Later change in NW China reflected uplift of the Qinghai-Xizang Plateau.•The Mongol-Xinjiang highlands were one biotic province since the middle Cenozoic.
Efficient packing of items into bins is a common daily task. Known as Bin Packing Problem, it has been intensively studied in the field of artificial intelligence, thanks to the wide interest from ...industry and logistics. Since decades, many variants have been proposed, with the three-dimensional Bin Packing Problem as the closest one to real-world use cases. We introduce a hybrid quantum-classical framework for solving real-world three-dimensional Bin Packing Problems (Q4RealBPP), considering different realistic characteristics, such as1) package and bin dimensions, (2) overweight restrictions, (3) affinities among item categories and (4) preferences for item ordering. Q4RealBPP permits the solving of real-world oriented instances of 3 dBPP, contemplating restrictions well appreciated by industrial and logistics sectors.
We propose the combination of digital quantum simulation and variational quantum algorithms as an alternative approach to numerical methods for solving quantum control problems. As a hybrid ...quantum-classical framework, it provides an efficient simulation of quantum dynamics compared to classical algorithms, exploiting the previous achievements in digital quantum simulation. We analyze the trainability and the performance of such algorithms based on our preliminary works. We show that specific quantum control problems, e.g., finding the switching time for bang-bang control or the digital quantum annealing schedule, can already be studied in the noisy intermediate-scale quantum era. We foresee that these algorithms will contribute even more to quantum control of high precision if the hardware for experimental implementation is developed to the next level.
Abstract Single administration of low-dose ketamine has both acute and sustained anti-depressant effects. Sustained effect is associated with restoration of glutamatergic synapses in medial ...prefrontal cortic (mFPC) neurons. Ketamine induced profound changes in a number of molecular pathways in a mouse model for chronic stress. Cell-cell communication analyses predicted that planar-cell-polarity (PCP) signaling was decreased after chronic administration of corticosterone but increased following ketamine administration in most of the excitatory neurons. Similar decrease of PCP signaling in excitatory neurons was predicted in dorsolateral prefrontal cortical (dl-PFC) neurons of patients with major depressive disorder (MDD). We showed that the basolateral amygdala (BLA)-projecting infralimbic prefrontal cortex (IL PFC) neurons regulate immobility time in the tail suspension test and food consumption. Conditionally knocking out Celsr2 and Celsr3 or Prickle2 in the BLA-projecting IL PFC neurons abolished ketamine-induced synapse restoration and behavioral remission. Therefore, PCP proteins in IL PFC-BLA neurons mediate synapse restoration induced by of low-dose ketamine.
We apply an invariant-based inverse engineering method to control, by time-dependent electric fields, the spin dynamics in a quantum dot with spin-orbit coupling in a weak magnetic field. The ...designed electric fields provide a shortcut to adiabatic processes that flip the spin rapidly, thus avoiding decoherence effects. This approach, being robust with respect to the device-dependent noise, can open new possibilities for spin-based quantum information processing.
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