O Coração e a COVID-19: O que o Cardiologista Precisa Saber Costa, Isabela Bispo Santos da Silva; Bittar, Cristina Salvadori; Rizk, Stephanie Itala ...
Arquivos Brasileiros de Cardiologia,
05/2020, Letnik:
114, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Frente à pandemia da doença causada pelo novo coronavírus (COVID-19), o manejo do paciente com fator de risco e/ou doença cardiovascular é desafiador nos dias de hoje. As complicações ...cardiovasculares evidenciadas nos pacientes com COVID-19 resultam de vários mecanismos, que vão desde lesão direta pelo vírus até complicações secundárias à resposta inflamatória e trombótica desencadeada pela infecção. O cuidado adequado do paciente com COVID-19 exige atenção ao sistema cardiovascular em busca de melhores desfechos.
The Heart and COVID-19: What Cardiologists Need to Know Costa, Isabela Bispo Santos da Silva; Bittar, Cristina Salvadori; Rizk, Stephanie Itala ...
Arquivos brasileiros de cardiologia,
05/2020, Letnik:
114, Številka:
5
Journal Article
Recenzirano
Odprti dostop
In face of the pandemic of the novel coronavirus disease 2019 (COVID-19), the management of patients with cardiovascular risk factors and/or disease is challenging. The cardiovascular complications ...evidenced in patients with COVID-19 derive from several mechanisms, ranging from direct viral injury to complications secondary to the inflammatory and thrombotic responses to the infection. The proper care of patients with COVID-19 requires special attention to the cardiovascular system aimed at better outcomes.
Since Barnard's first heterotopic heart transplant in 1974, Copeland's method has been the greatest contribution to heterotopic transplants but has the drawback of donor's right ventricular atrophy. ...This new method proposes a modification in the anastomosis of the superior vena cava aiming to pre-serve donor's right ventricular function by decompressing the pulmonary territory and reducing the pulmonary arterial pressure, as a biological ventricular assist device. Finally, a second intervention is proposed, where a "twist" is performed to place the donor's heart in an orthotopic position after re-moval of the native heart. A pioneering research on this method received approval from the ethics committee of the Heart Institute of São Paulo. We believe that this method has the potential to im-prove quality of life in a selected group of patients.
The environment where plants grow, such as acidic soils, interferes with the nutrient concentration and physiological quality of seeds. This hypothesis was tested using wheat seeds as a model crop, ...grown in a tropical soil with and without lime application for twelve years. Here we show that lime provides remarkable enhancements in soil chemistry and seed composition, without altering the seed's germination and vigor. Also, it favors the production of seeds with additional molecular mechanisms that extend their longevity. Our results indicate that the application of lime mitigates acidity in tropical soils and ensures the production of seeds with enhanced chemical composition and longer life span.
The routine practice of self-medication of blood pressure (BP) not oriented with pulse devices may not be precisely useful in the control of BP and can lead the patient to self-medicate in error. ...Thus, we need to evaluate the non-oriented self-assessment of BP in real-life circumstances in hypertensive patients. The objective of this study was to evaluate in hypertensive patients the association of BP self-measurement with its control, as well as the presence of anxiety disorders, the occurrence of unscheduled visits to the emergency room, and self-medication.
An observational study was carried out with 1000 hypertensive volunteers (age: 61.0 ± 12.5). Using a questionnaire, sociodemographic and clinical data on BP control were collected. Anxiety was assessed by the State-Trait Anxiety Inventory (STAI).
The group that performed non-oriented self-measurement of BP, showed that they had higher frequencies of self-medication (57.9%,
< 0.05) and more unscheduled visits to the emergency room (68%,
< 0.05). In addition, a lower level of BP control (46.8%,
< 0.05) was associated with higher levels of anxiety (52.3%,
< 0.05) in the group that performed non-oriented self-measurements of BP.
The practice of non-oriented self-assessment of BP was associated with negative factors such as high levels of anxiety and higher frequencies of self-medication and unscheduled emergency visits.
A principal via de transporte dos ribeirinhos amazônicos são os rios. Neste universo um grande problema são os meios de locomoção disponíveis: quando as embarcações são modernas têm alto custo; ...quando são mais rústicas não oferecem segurança nem desempenho. O objetivo deste trabalho foi propor um aerobarco de baixo custo de aquisição e manutenção, que possa ser construído pelos próprios ribeirinhos, sendo operado com segurança. Foi utilizada a metodologia de projeto naval da espiral de projeto. Como resultado foram obtidos os desenhos conceituais do aerobarco e possíveis simulações de carregamento, sendo concluída a viabilidade técnica da embarcação, assim como o pouco custo de fabricação.
The identification of the genes responsible for complex traits is highly promising to accelerate crop breeding, but such information is still limited for popcorn. Thus, in the present study, a mixed ...linear model-based association analysis (MLMA) was applied for six important popcorn traits: plant and ear height, 100-grain weight, popping expansion, grain yield and expanded popcorn volume per hectare. To this end, 196 plants of the open-pollinated popcorn population UENF-14 were sampled, selfed (S1), and then genotyped with a panel of 10,507 single nucleotide polymorphisms (SNPs) markers distributed throughout the genome. The six traits were studied under two environments Campos dos Goytacazes-RJ (ENV1) and Itaocara-RJ (ENV2) in an incomplete block design. Based on the phenotypic data of the S1 progenies and on the genetic characteristics of the parents, the MLMA was performed. Thereafter, genes annotated in the MaizeGDB platform were screened for potential linkage disequilibrium with the SNPs associated to the six evaluated traits. Overall, seven and eight genes were identified as associated with the traits in ENV1 and ENV2, respectively, and proteins encoded by these genes were evaluated for their function. The results obtained here contribute to increase knowledge on the genetic architecture of the six evaluated traits and might be used for marker-assisted selection in breeding programs.
During the Zika virus (ZIKV) outbreak in Brazil (2015-2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not ...previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys (Saimiri collinsi) infected during different gestational thirds (GTs) and assessed all clinical aspects, diagnostic imaging, viremia and the immune response. In our study, 75% of the infected animals in the 1st GT group had significant clinical manifestations, such as miscarriage and prolonged viremia associated with a late immune response. Consequently, their neonates showed fetal neuropathology, such as cerebral hemorrhage, lissencephaly or malformations of the brain grooves, ventriculomegaly, and craniofacial malformations. Thus, our study demonstrated the relevance of pregnant squirrel monkeys as a model for the study of ZIKV infection in neonates due to the broad clinical manifestations presented, including the typical congenital Zika syndrome manifestations described in humans.
First of all, we must emphasize that our method proposal is not, strictly speaking, a heterotopic heart transplantation, instead, the donor’s heart is set in heterotopic position aiming reduction of ...pulmonary vascular resistance so that, in an opportune time, when pulmonary pressure decreases, a second and final surgery is performed making a “twist”, as we will place the donor’s heart on orthotopic position. Besides that, continuous dilation of the myocardium provides a favorable site for endocarditis. ...your concern about clinical indication and clinical practice of our proposal method, we briefly explain that it is the point of our research, and two hearts are two organs to control, which one is healthy and the other, even with regression of pulmonary pressure, is still an organ that suffered with pulmonary hypertension and its disfunction could be catastrophic.
This study aimed to develop a polymeric matrix of polyamide-6 (P6) impregnated with trimetaphosphate (TMP) nanoparticles and silver nanoparticles (AgNPs), and to evaluate its antimicrobial activity, ...surface free energy, TMP and Ag
release, and cytotoxicity for use as a support in dental tissue. The data were subjected to statistical analysis (
< 0.05). P6 can be incorporated into TMP without altering its properties. In the first three hours, Ag
was released for all groups decorated with AgNPs, and for TMP, the release only occurred for the P6-TMP-5% and P6-TMP-10% groups. In the inhibition zones, the AgNPs showed activity against both microorganisms. The P6-TMP-2.5%-Ag and P6-TMP-5%-Ag groups with AgNPs showed a greater reduction in CFU for
. For
, all groups showed a reduction in CFU. The P6-TMP groups showed higher cell viability, regardless of time (
< 0.05). The developed P6 polymeric matrix impregnated with TMP and AgNPs demonstrated promising antimicrobial properties against the tested microorganisms, making it a potential material for applications in scaffolds in dental tissues.
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