'The Gnostic Syndrome' discusses anorexia nervosa in terms of its poetics and in the context of a developmental object-relations theory. One case is used to illustrate the problems of therapy and the ...antecedents of the anorexia in childhood and adolescence. The paper forms an investigation into pre-moral states and the interaction of anorexia with character structure.
THE AUTHOR EXAMINES THE ADLERIAN CONCEPTUALIZATION OF EARLY RECOLLECTIONS IN RELATION TO THE SYNDROME OF ANOREXIA NERVOSA. ADLER REFERRED TO THE SYNDROME AS "THE NEUROTIC HUNGER-STRIKE" & ...CONCEPTUALIZED IT AS HAVING MUCH IN COMMON WITH WHAT HE CALLED "ORGAN DIALECT" IN WHICH DISTURBANCE OF OF FUNCTION EXPRESSES THE DIRECTION THAT AN INDIVIDUAL IS TAKING TO ATTAIN HIS GOAL. 3 CASE HISTORIES ARE PRESENTED.
A review of the literature in the area of hypnotic dreams suggests that physiological correlates of hypnotic dreams are better established than content characteristics. A study is also reported that ...examined the content of hypnotic dreams in relation to that of nocturnal dreams and daydreams from the same Ss. Ss were 16 undergraduates divided into deep-trance and medium-trance groups. Deep trance Ss' hypnotic dreams were similar to their nocturnal dreams and different from daydreams on a wide variety of characteristics including length, emotional themes, characters, setting, and amount of distortion. Medium trance Ss' hypnotic dreams were found to fall between their nocturnal dreams and daydreams on most of these measures. (22 ref)
Archaeological faunal remains provide key insights into human societies in the past, alongside information on previous resource utilisation and exploitation of wildlife populations. The great whales ...(Mysticete and sperm whales) were hunted unsustainably throughout the 16th - 20th centuries (herein defined as the modern period) leading to large population declines and variable recovery patterns among species. Humans have utilised whales as a resource through carcass scavenging for millennia; however, increasing local and regional ethnographic and archaeological evidence suggests that, prior to the modern period, hunting of the great whales was more common than previously thought; impacts of earlier hunting pressures on the population ecology of many whale species remains relatively unknown. Hunting guided by traditional ecological knowledge may have been sustainable and likely originated in societies that also incorporated opportunistic use of stranded individuals. The collation of georeferenced zooarchaeological data of the great whales between the 1st - 20th centuries CE worldwide will provide insight into the timescale and distribution of resource utilisation of the great whales and how this varied within and between societies, and may have changed over time. By comparing regions of known resource utilisation and breeding and feeding grounds of current-day whale populations, this information will subsequently be used to infer regions where whale populations were possibly lost or extirpated prior to detailed historical records. This systematic review protocol also provides a template for archaeologists, ecologists, and historians interested in using faunal remains to infer historical ecology and resource use of wild animal populations. The transparency of our data collection approach provides opportunities for reproducibility and comparability with future datasets.
Intermediaries are health-related workers who facilitate connections to local physical activities. Intermediaries deliver interventions by receiving referrals, conducting assessments, connecting ...referred individuals to activities and/or services in the community, and following up with them over time. However, it is unclear whether individuals who are referred to physical activities by an intermediary improve their physical activity levels, and what their perspectives and experiences are of participating in this intervention. To date there has been a lack of studies investigating the effect of this intervention on physical activity using appropriate outcome measures.
This will be a mixed methods pilot feasibility study. Participants will be individuals referred or self-referred to an intermediary and connected to local physical activities. Participants will be recruited through two types of intermediary services in Ireland; social prescribing and local sports partnerships. A total of 30 participants will be recruited (15 per service). Baseline demographic information will be taken upon enrolment to the study and three questionnaires will be completed: the International Physical Activity Questionnaire - Short Form, Self-Efficacy for Exercise Scale and Short Warwick Edinburgh Mental Well-being Scale. The questionnaires will be repeated after 12 weeks and in addition semi-structured interviews will be carried out to explore intervention content and delivery, as well as acceptability of the intervention and evaluation design.
This overall aim of this proposed study is to investigate the feasibility of an intervention delivered by an intermediary to improve physical activity and health-related outcomes of community-dwelling adults.
Clinical Trials.Gov (NCT06260995).
•Local physical activities can help address the problem of physical inactivity.•Intermediaries facilitate connections to local physical activities.•Few studies have investigated feasibility or acceptability of this intervention.•This study will test feasibility of intermediary interventions to improve health.
Genetic mutations cause primary immunodeficiencies (PIDs) that predispose to infections. Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation ...in which lysine replaced glutamk acid at residue 1021 (E1021K) in the p110δ protein, the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ), encoded by the PIK3CD gene. We found E1021K in 17 patients from seven unrelated families, but not among 3346 healthy subjects. APDS was characterized by recurrent respiratory infections, progressive airway damage, lymphopenia, increased circulating transitional B cells, increased immunoglobulin M, and reduced immunoglobulin G2 levels in serum and impaired vaccine responses. The E1021K mutation enhanced membrane association and kinase activity of p110δ. Patient-derived lymphocytes had increased levels of phosphatidylinositol 3,4,5-trisphosphate and phosphorylated AKT protein and were prone to activation-induced cell death. Selective p110δ inhibitors IC87114 and GS-1101 reduced the activity of the mutant enzyme in vitro, which suggested a therapeutic approach for patients with APDS.
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