The hot-Jupiter WASP-10b was reported by Maciejewski et al. to show transit timing variations (TTVs) with an amplitude of ∼3.5 min. These authors proposed that the observed TTVs were caused by a 0.1M
...Jup perturbing companion with an orbital period of ∼5.23 d, and hence, close to the outer 5:3 mean-motion resonance with WASP-10b. To test this scenario, we present eight new transit light curves of WASP-10b obtained with the Faulkes Telescope North and the Liverpool Telescope. The new light curves, together with 22 previously published ones, were modelled with a Markov Chain Monte Carlo transit fitting code. Transit depth differences reported for WASP-10b are thought to be due to starspot-induced brightness modulation of the host star. Assuming the star is brighter at the activity minimum, we favour a small planetary radius. We find
in agreement with Johnson et al. and Maciejewski et al. Recent studies find no evidence for a significant eccentricity in this system. We present consistent system parameters for a circular orbit and refine the orbital ephemeris of WASP-10b. Our homogeneously derived transit times do not support the previous claimed TTV signal, which was strongly dependent on two previously published transits that have been incorrectly normalized. Nevertheless, a linear ephemeris is not a statistically good fit to the transit times of WASP-10b. We show that the observed transit time variations are due to spot occultation features or systematics. We discuss and exemplify the effects of occultation spot features in the measured transit times and show that despite spot occultation during egress and ingress being difficult to distinguish in the transit light curves, they have a significant effect in the measured transit times. We conclude that if we account for spot features, the transit times of WASP-10b are consistent with a linear ephemeris with the exception of one transit (epoch 143) which is a partial transit. Therefore, there is currently no evidence for the existence of a companion to WASP-10b. Our results support the lack of TTVs of hot-Jupiters reported for the Kepler sample.
K2-19 is the second multiplanetary system discovered with K2 observations. The system is composed of two Neptune size planets close to the 3:2 mean-motion resonance. To better characterize the system ...we obtained two additional transit observations of K2-19b and five additional radial velocity observations. These were combined with K2 data and fitted simultaneously with the system dynamics (photodynamical model) which increases the precision of the transit time measurements. The higher transit time precision allows us to detect the chopping signal of the dynamic interaction of the planets that in turn permits to uniquely characterize the system. Although the reflex motion of the star was not detected, dynamic modelling of the system allowed us to derive planetary masses of M
b
= 44 ± 12 M⊕ and M
c
= 15.9 ± 7.0 M⊕ for the inner and the outer planets, respectively, leading to densities close to Uranus. We also show that our method allows the derivation of mass ratios using only the 80 d of observations during the first campaign of K2.
We present the discovery of three new transiting giant planets, first detected with the WASP telescopes, and establish their planetary nature with follow up spectroscopy and ground-based photometric ...light curves. WASP-92 is an F7 star, with a moderately inflated planet orbiting with a period of 2.17 d, which has R sub( p) = 1.461 plus or minus 0.077R sub( J) and M sub( p) = 0.805 plus or minus 0.068M sub( J). WASP-93b orbits its F4 host star every 2.73 d and has R sub( p) = 1.597 plus or minus 0.077R sub( J) and M sub( p) = 1.47 plus or minus 0.029M sub( J). WASP-118b also has a hot host star (F6) and is moderately inflated, where R sub( p) = 1.440 plus or minus 0.036R sub( J) and M sub( p) = 0.514 plus or minus 0.020M sub( J) and the planet has an orbital period of 4.05 d. They are bright targets (V = 13.18, 10.97 and 11.07, respectively) ideal for further characterization work, particularly WASP-118b, which is being observed by K2 as part of campaign 8. The WASP-93 system has sufficient angular momentum to be tidally migrating outwards if the system is near spin-orbit alignment, which is divergent from the tidal behaviour of the majority of hot Jupiters discovered.
We obtained high-resolution, high-contrast optical imaging in the Sloan Digital Sky Survey i
′ band with the LuckyCam camera mounted on the 2.56 m Nordic Optical Telescope, to search for faint ...stellar companions to 16 stars harbouring transiting exoplanets. The Lucky imaging technique uses very short exposures to obtain near diffraction-limited images yielding sub-arcsecond sensitivity, allowing us to search for faint stellar companions within the seeing disc of the primary planet host. Here, we report the detection of two candidate stellar companions to the planet host TrES-1 at separations <6.5 arcsec and we confirm stellar companions to CoRoT-2, CoRoT-3, TrES-2, TrES-4 and HAT-P-7 already known in the literature. We do not confirm the candidate companions to HAT-P-8 found via Lucky imaging by Bergfors et al., however, most probably because HAT-P-8 was observed in poor seeing conditions. Our detection sensitivity limits allow us to place constraints on the spectral types and masses of the putative bound companions to the planet host stars in our sample. If bound, the stellar companions identified in this work would provide stringent observational constraints to models of planet formation and evolution. In addition, these companions could affect the derived physical properties of the exoplanets in these systems.
We present the first results of a dedicated search for pulsating white dwarfs (WDs) in detached WD plus main-sequence (MS) binaries. Candidate systems were selected from a catalogue of WD+MS ...binaries, based on the surface gravities and effective temperatures of the WDs. We observed a total of 26 systems using ULTRACAM mounted on ESO's 3.5 m New Technology Telescope at La Silla. Our photometric observations reveal pulsations in seven WDs of our sample, including the first pulsating WD with an MS companion in a post-common envelope (CE) binary, SDSS J1136+0409. Asteroseismology of these new pulsating systems will provide crucial insight into how binary interactions, particularly the CE phase, affect the internal structure and evolution of WDs. In addition, our observations have revealed the partially eclipsing nature of one of our targets, SDSS J1223−0056.
Summary In this Series paper, we review trends since the 2005 Lancet Series on Neonatal Survival to inform acceleration of progress for newborn health post-2015. On the basis of multicountry analyses ...and multi-stakeholder consultations, we propose national targets for 2035 of no more than 10 stillbirths per 1000 total births, and no more than 10 neonatal deaths per 1000 livebirths, compatible with the under-5 mortality targets of no more than 20 per 1000 livebirths. We also give targets for 2030. Reduction of neonatal mortality has been slower than that for maternal and child (1–59 months) mortality, slowest in the highest burden countries, especially in Africa, and reduction is even slower for stillbirth rates. Birth is the time of highest risk, when more than 40% of maternal deaths (total about 290 000) and stillbirths or neonatal deaths (5·5 million) occur every year. These deaths happen rapidly, needing a rapid response by health-care workers. The 2·9 million annual neonatal deaths worldwide are attributable to three main causes: infections (0·6 million), intrapartum conditions (0·7 million), and preterm birth complications (1·0 million). Boys have a higher biological risk of neonatal death, but girls often have a higher social risk. Small size at birth—due to preterm birth or small-for-gestational-age (SGA), or both—is the biggest risk factor for more than 80% of neonatal deaths and increases risk of post-neonatal mortality, growth failure, and adult-onset non-communicable diseases. South Asia has the highest SGA rates and sub-Saharan Africa has the highest preterm birth rates. Babies who are term SGA low birthweight (10·4 million in these regions) are at risk of stunting and adult-onset metabolic conditions. 15 million preterm births, especially of those younger than 32 weeks' gestation, are at the highest risk of neonatal death, with ongoing post-neonatal mortality risk, and important risk of long-term neurodevelopmental impairment, stunting, and non-communicable conditions. 4 million neonates annually have other life-threatening or disabling conditions including intrapartum-related brain injury, severe bacterial infections, or pathological jaundice. Half of the world's newborn babies do not get a birth certificate, and most neonatal deaths and almost all stillbirths have no death certificate. To count deaths is crucial to change them. Failure to improve birth outcomes by 2035 will result in an estimated 116 million deaths, 99 million survivors with disability or lost development potential, and millions of adults at increased risk of non-communicable diseases after low birthweight. In the post-2015 era, improvements in child survival, development, and human capital depend on ensuring a healthy start for every newborn baby—the citizens and workforce of the future.
Objectives
Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate‐related osteonecrosis of the jaw (BRONJ).
Materials and Methods
Male ...Wistar rats (n = 6–7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg−1 (1.4 × 10−7, 6.9 × 10−6, and 3.4 × 10−5 mol kg−1), and subsequently, the first left inferior molar was extracted. Were performed counting of viable and empty osteocyte lacunae, viable and apoptotic osteoclasts, polymorphonuclear neutrophil, mast cells (toluidine blue), and the positive presence cells for CD68, tumor necrosis factor‐alpha (TNF‐α), IL (interleukin)‐1β, inducible nitric oxide synthase (iNOS), nuclear factor‐kappa B (NF‐kB) and IL‐18 binding protein (IL‐18 bp).
Results
BRONJ was showed in ZA treated with 0.20 and 1.00 mg kg−1. There is a dose dependent increase in percentage of empty osteocyte lacunae (P < 0.001) and apoptotic osteoclasts (P < 0.001), counting of total osteoclasts (P = 0.003), polymorphonuclear neutrophil cells (P = 0.009), cytoplasmic‐positive cells of CD68 (P < 0.001), TNF‐α (P = 0.001), IL‐1β (P = 0.001), iNOS (P < 0.001), NF‐kB (P = 0.006), and nuclear‐positive cells of NF‐kB (P = 0.011). Consequently, there is no difference in mast cells (P = 0.957), and IL‐18 bp immunostaining decreases dose dependently (P = 0.005).
Conclusions
BRONJ is characterized by increases in immunostaining for proinflammatory markers and NF‐kB and inversely associated with cells exhibiting IL‐18 bp.
BACKGROUNDOral Potentially Malignant Disorders (OPMDs) are defined as lesions with a greater likelihood of progressing to cancer. Population-based studies that evaluate the prevalence of OPMDs are ...scarce in Brazil. The aim of the present study was to determine the prevalence of OPMDs and associated risk factors in a semi-urban Brazilian population. MATERIAL AND METHODSThis is a cross-sectional study, whose universe included individuals aged 40 years or older residing in a medium-sized city of northeastern Brazil. Data collection was divided into two steps: interview and oral examination. The outcome variable was the presence of OPMDs. The predictor variables were sociodemographic characteristics and risk habits. The bivariate analysis was performed through chi-square test. The crude prevalence ratios (PR) and its respective 95% confidence intervals (CI) were calculated. Poisson regression analysis with robust variance was used to calculate adjusted PRs and 95% CI. RESULTSThree hundred fourteen individuals were included in the study. When asked about risk habits, 58.9% reported being current smokers or ex-smokers and 62.2% reported being current drinkers or ex-drinkers. The prevalence of OPMDs was 7.6% and was significantly higher among individuals with black skin color (p < 0.001), alcohol users (p = 0.017), and individuals with both tobacco and alcohol habits (p = 0.012). CONCLUSIONSTherefore, the population in the present study had a high frequency of risk habits associated with PMDs of the oral cavity.
Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as ...increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D. Herein, we analyzed the association of these SNPs with T2D in a population from northeastern Brazil. Our results showed that the genotype and allele frequencies in TCF7L2 rs7903146 and rs12255372 were similar in the patient and control groups (P > 0.05). In addition, the allele frequencies were not significantly associated with T2D risk rs7903146: odds ratio (OR) = 0.95, 95% confidence interval (CI) = 0.52-1.76, P = 1.00, and rs12255372: OR = 1.38, 95%CI = 0.72-2.62, P = 0.41. These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. However, our results may reflect the small number of subjects. Alternatively, these results may be attributable to specific ethnic effects, as most of the previously reported associations were demonstrated with predominantly European populations. To reach a definitive conclusion on the role of such gene variants for T2D in mixed populations, additional efforts are necessary to replicate this study with larger populations from areas with more ethnic heterogeneity.
The study objective is to propose bioelectrical impedance vector analysis (BIVA) ellipses for the population and investigate its use to assess nutritional status through the BMI/age ratio and the ...cardiovascular risk through waist circumference (WC).
Age, weight, height and WC were recorded, along with the values of resistance (R), reactance (Xc) and phase angle (PA) by impedance. Student's t test and ANOVA were applied to ascertain the significance between means and a specific programme was applied to investigate the significance between ellipses.
Fortaleza, Brazil.
A total of 467 students from public schools participated in the study: 120 children and 347 adolescents were evaluated, with respective means of age, weight and height of 8·2 years, 27·6 kg and 1·29 m and 12·7 years, 48·6 kg and 1·53 m, respectively.
The mean values of R/H, Xc/H and PA were 569·0 and 424·7 Ohm/m, 59·1 and 50·4 Ohm/m, and 5·9º and 6·8º for children and adolescents, respectively. The mean vectors for R/H and Xc/H show significant differences between for both age ranges and are inversely proportional to the BMI/A. As for WC, individuals without cardiovascular risk had higher R/H and lower Xc/H, but Xc and R in participants without cardiovascular risk were greater than with cardiovascular risk.
It was possible to propose confidence and tolerance BIVA ellipses for children and adolescent's clinical evaluation. The method was also suitable to identify cardiovascular risk ellipses in these age groups, but it was not possible to draw nutritional classifications ellipses by BMI/age data.
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