Poduzetnički način razmišljanja može se opisati kao sposobnost uočavanja poduzetničkih prilika, sklonost proaktivnom i inovativnom djelovanju te spremnost za preuzimanje rizika. Poduzetnički način ...razmišljanja i djelovanja jedan je od ključnih pokretača svake privrede. Rad se bavi analizom poduzetničke orijentacije pripadnika Y i Z generacije koji će u skorije vrijeme činiti većinu radno i poduzetnički aktivne populacije. U radu se prikazuju rezultati provedenog istraživanja odrednica poduzetničke orijentacije na uzorku od 216 studenata Y generacije i 322 studenta Z generacije. Polazne pretpostavke istraživanja, postavljene na temelju prethodnog pregleda literature, bile su da se pripadnici Y i Z generacije meðusobno razlikuju prema odrednicama poduzetničke orijentacije (inovativnosti, proaktivnosti i preuzimanja rizika) te da su pripadnici Z generacije proaktivniji, inovativniji i skloniji preuzimanju rizika u odnosu na pripadnike Y generacije. Na temelju rezultata provedenog istraživanja potvrðena je statistički značajna razlika u dimenzijama poduzetničke orijentacije izmeðu pripadnika različitih generacija, ali u korist pripadnika Y generacije.
Multivalent protein interactors are an attractive modality for probing protein function and exploring novel pharmaceutical strategies. The throughput and precision of state-of-the-art methodologies ...and workflows for the effective development of multivalent binders is currently limited by surface immobilization, fluorescent labelling and sample consumption. Using the gephyrin protein, the master regulator of the inhibitory synapse, as benchmark, we exemplify the application of Fluorescence proximity sensing (FPS) for the systematic kinetic and thermodynamic optimization of multivalent peptide architectures. High throughput synthesis of +100 peptides with varying combinatorial dimeric, tetrameric, and octameric architectures combined with direct FPS measurements resolved on-rates, off-rates, and dissociation constants with high accuracy and low sample consumption compared to three complementary technologies. The dataset and its machine learning-based analysis deciphered the relationship of specific architectural features and binding kinetics and thereby identified binders with unprecedented protein inhibition capacity; thus, highlighting the value of FPS for the rational engineering of multivalent inhibitors.
Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic ...variations in
gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. This is the first study investigating the association of
TA repeats promoter genotypes with the degree of liver injury, viremia and biochemical markers in CHC patients with advanced liver injury and late virological relapse.
Genetic testing of
TA repeats promoter genotypes was performed in 42 CHC patients with advanced fibrosis and cirrhosis who achieved sustained virological response and 42 healthy blood donors. CHC patients were evaluated for clinical findings, laboratory tests and imaging.
*28 genotype (7/7 TA repeats) was observed in 23.8% CHC patients and 16.7% healthy controls with no significant difference in genotype frequencies (p=0.49). Pretreatment levels of ferritin and bilirubin were associated with the presence of
genotype, indicating its potential as a predictive marker. However, in our study, there was no correlation of
genotype with the degree of fibrosis or viremia. During antiviral treatment, dose reductions and treatment interruptions, as well as treatment success and occurrence of late virological relapse were not related to the presence of
genotype in CHC patients with severe liver injury.
Frequencies of
genotype are high in both Serbian CHC patients and healthy subjects. The presence of
genotype was not associated with ribavirin-related adverse effects and had no effect on long term outcome in CHC patients.
Donošenje ispravnih odluka o marketinškom komuniciranju važanje čimbenik tržišnoga uspjeha. Kako bi pridobili i zadržali potrošače,poduzeća ulažu značajne napore u razumijevanje njihovih potrebai ...želja te u kreiranje personalizirane ponude i načina komunikacije.Direktna marketinška komunikacija ima obilježja neposrednosti,prilagodljivosti, personaliziranog pristupa, interaktivnosti i mjerljivosti.Pojavom digitalnih kanala dolazi do proširene primjene direktnemarketinške komunikacije koja danas uključuje direktni i digitalnimarketing. Ukratko su izložene odrednice supkulture promatranekroz generacijsku pripadnost na primjeru Y i Z generacije. Provedenoje kvantitativno istraživanje na uzorku od 200 ispitanika radi stjecanjauvida u stavove pripadnika Y i Z generacije prema odabranim alatimadirektne marketinške komunikacije. U radu su prikazani i interpretiranirezultati o sličnostima i razlikama u stavovima ispitanika te su navedenaograničenja istraživanja kao i preporuke za buduća istraživanja.
Making the right decisions about marketing communication isan important factor in market success. In order to gain and retainconsumers, companies invest significant efforts in understandingtheir needs and desires and in creating personalized offers andcommunication methods. Direct marketing communication hasthe following characteristics: immediacy, adaptability, personalizedapproach, interactivity and measurability. The development of digitalchannels leads to an expanded application of direct marketingcommunication, which is why today it includes direct and digitalmarketing. Determinants of the subculture are briefly presented, whichare observed through generational affiliation using the example of the Yand Z generations. A quantitative survey was conducted on a sample of200 respondents with the purpose of gaining insight into the attitudesof members of the Y and Z generations towards the selected tools ofdirect marketing communication. The paper presents and interprets theresults of the similarities and differences in the respondents’ attitudes,also, the limitations of the research as well as recommendations forfuture research.
Poduzetnički način razmišljanja može se opisati kao sposobnost uočavanja poduzetničkih prilika, sklonost proaktivnom i inovativnom djelovanju te spremnost za preuzimanje rizika. Poduzetnički način ...razmišljanja i djelovanja jedan je od ključnih pokretača svake privrede. Rad se bavi analizom poduzetničke orijentacije pripadnika Y i Z generacije koji će u skorije vrijeme činiti većinu radno i poduzetnički aktivne populacije. U radu se prikazuju rezultati provedenog istraživanja odrednica poduzetničke orijentacije na uzorku od 216 studenata Y generacije i 322 studenta Z generacije. Polazne pretpostavke istraživanja, postavljene na temelju prethodnog pregleda literature, bile su da se pripadnici Y i Z generacije međusobno razlikuju prema odrednicama poduzetničke orijentacije (inovativnosti, proaktivnosti i preuzimanja rizika) te da su pripadnici Z generacije proaktivniji, inovativniji i skloniji preuzimanju rizika u odnosu na pripadnike Y generacije. Na temelju rezultata provedenog istraživanja potvrđena je statistički značajna razlika u dimenzijama poduzetničke orijentacije između pripadnika različitih generacija, ali u korist pripadnika Y generacije.
Poduzetnički način razmišljanja može se opisati kao sposobnost uočavanja poduzetničkih prilika, sklonost proaktivnom i inovativnom djelovanju te spremnost za preuzimanje rizika. Poduzetnički način ...razmišljanja i djelovanja jedan je od ključnih pokretača svake privrede. Rad se bavi analizom poduzetničke orijentacije pripadnika Y i Z generacije koji će u skorije vrijeme činiti većinu radno i poduzetnički aktivne populacije. U radu se prikazuju rezultati provedenog istraživanja odrednica poduzetničke orijentacije na uzorku od 216 studenata Y generacije i 322 studenta Z generacije. Polazne pretpostavke istraživanja, postavljene na temelju prethodnog pregleda literature, bile su da se pripadnici Y i Z generacije međusobno razlikuju prema odrednicama poduzetničke orijentacije (inovativnosti, proaktivnosti i preuzimanja rizika) te da su pripadnici Z generacije proaktivniji, inovativniji i skloniji preuzimanju rizika u odnosu na pripadnike Y generacije. Na temelju rezultata provedenog istraživanja potvrđena je statistički značajna razlika u dimenzijama poduzetničke orijentacije između pripadnika različitih generacija, ali u korist pripadnika Y generacije.
Entrepreneurship within organisation is a key prerequisite of entrepreneurial and economic growth. Factors of organisational support such as financial rewards are important for entrepreneurial ...activity within the framework of existing organisational structures. Business performance and its organisational prerequisites are in a feedback loop. Frequently financial results are a determinant of financial rewards and they are a strong motivation for entrepreneurial activities of employees upon which the further entrepreneurial growth and development depend. In order to achieve its sustainability, market success should be observed through multiple, financial and non-financial indicators and absolute and relative measures, especially if business result is the basis for determining organisational incentives of employees' entrepreneurial activity. The aim of this paper is to examine the perception of management in Croatia regarding financial rewards as a key factor of organisational incentives within organisations and related tax instruments as a key determinant of their implementation. A structured questionnaire was used with this aim to test 62 small and medium-sized enterprises in Croatia with a pronounced entrepreneurial activity of employees. The research led to a conclusion that in Croatian companies the importance of financial rewards as a key factor in supporting entrepreneurial activities within organisation is not sufficiently recognised. In the process of financial rewarding, individual rewards are used exclusively, which were proven to be the least efficient financial instrument to the entrepreneurial activity of employees. The surveyed managers confirmed the assumption that the tax system has a significant impact on the choice ofform and sum of employees' financial rewards used, but it does not provide the necessary incentive and support in this sense.
Executors of entrepreneurial processes are individuals who undertake entrepreneurial activities in interaction with microenvironment and macroenvironment factors. The entrepreneurial environment ...affects the entrepreneurial activity executors and thus the type of entrepreneurial activity. Therefore, entrepreneurship is observed at the individual and organizational level, taking into account the national and organizational context of entrepreneurial activity. It has been established that in developed economies, entrepreneurship within the organization is a substitute for lower rates of undertaking new entrepreneurial ventures, and in developing countries it represents a greater possibility of surviving initial entrepreneurial activities. Employee entrepreneurial activity implies a novelty for which it is necessary to timely identify and seize opportunities. Opportunity-based entrepreneurship is based on the knowledge necessary to identify and gather the necessary information. Entrepreneurial knowledge and skills place the available information in a unique entrepreneurial context that represents an opportunity for entrepreneurial action. Entrepreneurship education is considered an important factor in organizational support for entrepreneurial activity within an organization. Tax relief, as an incentive for investment in entrepreneurship education of employees, enables the acquisition of specific knowledge, entrepreneurial skills and entrepreneurial orientation necessary to undertake entrepreneurial activity for the needs of the organization.
Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic ...variations in
gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. This is the first study investigating the association of
TA repeats promoter genotypes with the degree of liver injury, viremia and biochemical markers in CHC patients with advanced liver injury and late virological relapse.
Genetic testing of
TA repeats promoter genotypes was performed in 42 CHC patients with advanced fibrosis and cirrhosis who achieved sustained virological response and 42 healthy blood donors. CHC patients were evaluated for clinical findings, laboratory tests and imaging.
*28 genotype (7/7 TA repeats) was observed in 23.8% CHC patients and 16.7% healthy controls with no significant difference in genotype frequencies (p=0.49). Pretreatment levels of ferritin and bilirubin were associated with the presence of
genotype, indicating its potential as a predictive marker. However, in our study, there was no correlation of
genotype with the degree of fibrosis or viremia. During antiviral treatment, dose reductions and treatment interruptions, as well as treatment success and occurrence of late virological relapse were not related to the presence of
genotype in CHC patients with severe liver injury.
Frequencies of
genotype are high in both Serbian CHC patients and healthy subjects. The presence of
genotype was not associated with ribavirin-related adverse effects and had no effect on long term outcome in CHC patients.
Summary
Background:
Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not ...elucidated. Genetic variations in
UGT1A1
gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. This is the first study investigating the association of
UGT1A1
TA repeats promoter genotypes with the degree of liver injury, viremia and biochemical markers in CHC patients with advanced liver injury and late virological relapse.
Methods:
Genetic testing of
UGT1A1
TA repeats promoter genotypes was performed in 42 CHC patients with advanced fibrosis and cirrhosis who achieved sustained virological response and 42 healthy blood donors. CHC patients were evaluated for clinical findings, laboratory tests and imaging.
Results:
UGT1A1
*28 genotype (7/7 TA repeats) was observed in 23.8% CHC patients and 16.7% healthy controls with no significant difference in genotype frequencies (p=0.49). Pretreatment levels of ferritin and bilirubin were associated with the presence of
UGT1A1*28
genotype, indicating its potential as a predictive marker. However, in our study, there was no correlation of
UGT1A1*28
genotype with the degree of fibrosis or viremia. During antiviral treatment, dose reductions and treatment interruptions, as well as treatment success and occurrence of late virological relapse were not related to the presence of
UGT1A1*28
genotype in CHC patients with severe liver injury.
Conclusions:
Frequencies of
UGT1A1*28
genotype are high in both Serbian CHC patients and healthy subjects. The presence of
UGT1A1*28
genotype was not associated with ribavirin-related adverse effects and had no effect on long term outcome in CHC patients.
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