Cyclin Dependent Kinases (CDKs) are important regulators of cell cycle and gene expression. Since an up-to-date review about the pharmacological inhibitors of CDK family (CDK1-10) is not available; ...therefore in the present paper we briefly summarize the most relevant inhibitors and point out the low number of selective inhibitors. Among CDKs, CDK9 is a validated pathological target in HIV infection, inflammation and cardiac hypertrophy; however selective CDK9 inhibitors are still not available. We present a selective inhibitor family of CDK9 based on the 4-phenylamino-6- phenylpyrimidine nucleus. We show a convenient synthetic method to prepare a useful intermediate and its derivatisation resulting in novel compounds. The CDK9 inhibitory activity of the derivatives was measured in specific kinase assay and the CDK inhibitory profile of the best ones (IC(50) < 100 nM) was determined. The most selective compounds had high selectivity over CDK1, 2, 3, 5, 6, 7 and showed at least one order of magnitude higher inhibitory activity over CDK4 inhibition. The most selective molecules were examined in cytotoxicity assays and their ability to inhibit HIV-1 replication was determined in cellular assays.
We have built a RICH detector prototype consisting of a liquid C6F14 radiator and six triple Thick Gaseous Electron Multipliers (TGEMs), each of them having an active area of 10×10cm2. One triple ...TGEM has been placed behind the liquid radiator in order to detect the beam particles, whereas the other five have been positioned around the central one at a distance to collect the Cherenkov photons. The upstream electrode of each of the TGEM stacks has been coated with a 0.4μm thick CsI layer.
In this paper, we will present the results from a series of laboratory tests performed with this prototype carried out using UV light, 6keV photons from 55Fe and electrons from 90Sr as well as recent results of tests with a beam of charged pions where for the first time Cherenkov Ring images have been successfully recorded with TGEM photodetectors. The achieved results prove the feasibility of building Cherenkov detector based on CsI coated TGEMs.
The VHMPID RICH upgrade project for ALICE at LHC Di Mauro, A.; Agocs, A.; Alfaro, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
05/2011, Letnik:
639, Številka:
1
Journal Article
Recenzirano
RHIC results have shown the importance of high momentum particles as hard probes and the need for particle identification (PID) in a very large momentum range. A Very High Momentum PID (VHMPID) ...detector has been proposed as upgrade of ALICE to extend the track-by-track identification capabilities for charged hadrons from the present 5
GeV/c limit to the momentum range 10–30
GeV/c. The VHMPID detector is a focusing RICH using C
4F
10 gaseous radiator coupled to a CsI-based photon detector. Detector design studies, achievable Cherenkov angle resolution, expected performance and high momentum triggering will be discussed.
We report on studies of layout and performance of a new Ring Imaging Cherenkov detector using for the first time pressurized C4F8O radiator gas and a photon detector consisting of a MWPC equipped ...with a CsI photocathode. In particular, we present here the results of beam tests of a MWPC having an adjustable anode–cathode gap, aiming at the optimization of single photoelectron detection and Cherenkov angle resolution. This system was proposed as a Very High Momentum Particle Identification (VHMPID) upgrade for the ALICE experiment at LHC to provide charged hadron track-by-track identification in the momentum range 5–25GeV/c.
•The concept and design of a novel RICH counter operated with pressurized gaseous Cherenkov radiator have been validated.•We used for the first time C4F8O gaseous Cherenkov radiator pressurized up to 3.5atm in a RICH counter.•The refractive index of C4F8O in the UV range is similar to the per-mil level to that of C4F10.•A variable gap MWPC has been used to optimize the layout of the gaseous photon counter, based on CsI photocathodes and MWPC, for the detection of single photoelectrons.
This study was conducted to analyze carotenoids from tomatoes by high-performance liquid chromatography using reversed-phase C18 silica having cross-linked end-capping with diode array and mass ...spectrometric detection. An efficient gradient elution system was developed to achieve good and reliable separation of both major and minor carotenoids as well as their isomers. Resolution of lycopene, β-carotene and their isomers was 0.91–3.97 and 1.02–2.86 with cross-linked and conventional C18 column, respectively. The % recovery for zeaxanthin, lycopene and β-carotene was found to be in the range of 89–97%. Limits of detection and quantification of 19.44 and 64.79 ng/mL for zeaxanthin, 15.6 and 52.4 ng/mL for lycopene and 8.28 and 27.61 ng/mL for β-carotene were determined. More carotenoid compounds could be separated and detected with the new method as compared with conventional C18 column. Hyphenation of HPLC with photodiode array and mass spectrometry detectors assisted in detection of tetra-dehydrocarotenoid and fatty acid diesters of xanthophylls in tomato products. Content of all-trans-lycopene, β-carotene and total carotenoid in different industrial tomatoes tested was found to range between 41.87 and 84.65, 0.89 and 1.50 and 53.22 and 112.60 µg/g fresh weight, respectively.
This document presents an overview of the induced photocurrents in the Amorphous Silicon Position Detectors used in the network of diode lasers and photo sensors of the CMS Link alignment system ...recorded during its eleven years of operation. After a description of the sensors characteristics, the layout of the sensors network is discussed. The sensors are distributed throughout the muon spectrometer and connected by laser lines. The data used correspond to readout information obtained during some of the physics runs from 2008 to 2018.
The central feature of the CMS Link alignment system is a network of Amorphous Silicon Position Detectors distributed throughout the muon spectrometer that are connected by multiple laser lines. The ...data collected during the years from 2008 to 2015 is presented confirming an outstanding performance of the photo sensors during more than seven years of operation. Details of the photo sensor readout of the laser signals are presented. The mechanical motions of the CMS detector are monitored using these photosensors and good agreement with distance sensors is obtained.
A small-size prototype of a new Ring Imaging Cherenkov (RICH) detector using for the first time pressurized C4F8O radiator gas and a photon detector consisting of MWPC equipped with a CsI ...photocathode has been built and tested at the PS accelerator at CERN. It contained all the functional elements of the detector proposed as Very High Momentum Particle Identification (VHMPID) upgrade for the ALICE experiment at LHC to provide charged hadron track-by-track identification in the momentum range starting from 5 potentially up to 25GeV/c. In the paper the equipment and its elements are described and some characteristic test results are shown.
A small-size prototype of a new Ring Imaging Cherenkov (RICH) detector using for the first time pressurized C4F8O radiator gas and a photon detector consisting of MWPC equipped with a CsI ...photocathode has been built and tested at the PS accelerator at CERN. It contained all the functional elements of the detector proposed as Very High Momentum Particle Identification (VHMPID) upgrade for the ALICE experiment at LHC to provide charged hadron track-by-track identification in the momentum range starting from 5 potentially up to 25 GeV/c. In the paper the equipment and its elements are described and some characteristic test results are shown.
A study of the time required for the CMS detector to reach structural equilibrium once the magnetic field is ramped to its operational value of 3.8T is presented. In addition, the results from a ...stability monitoring at 3.8T over an eight-month period are given.
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