Migraine is one of the most frequent primary headaches in childhood. The role of thrombotic predisposition in its pathogenesis is debated. Our aim was to analyse the cardiovascular risk factors and ...family history of major thrombotic events in children with migraine.
A retrospective, single-centre study was performed over 12 years. Our headache centre record database was screened for migraine with aura (MA) and migraine without aura (MO) on the basis of the ICHD-II (until 2013) and III criteria. A control group of otherwise healthy children was recruited. Descriptive and multivariate analyses are provided; significance was set at
< 0.05.
Migraine was diagnosed in 930 children (24.7% MA); 73.3% were 9-14 years old. Children with MA were older (
< 0.001). A family history of cerebral ischemic events at ≤50 years old was more commonly reported by children with MA than those with MO (
< 0.001) and those in the control group (
= 0.001). Children with MA showed a higher risk of a family history of cerebral ischemic events at ≤50 years old than children with MO (OR: 2.6) and those in the control group (OR: 3.1). When comparing the family history of DVT, we observed a significantly increased risk for MA vs. MO (OR: 2.9).
A family history of cerebral ischemic events at ≤50 years old leads to an increased risk of MA. Further studies are needed to explore such an association.
Abstract Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. ...Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology.
Background Neuroimaging studies of ultra-high risk (UHR) and first-episode psychosis (FEP) have revealed widespread alterations in brain structure and function. Recent evidence suggests there is an ...intrinsic relationship between these 2 types of alterations; however, there is very little research linking these 2 modalities in the early stages of psychosis. Methods To test the hypothesis that functional alteration in UHR and FEP participants would be associated with corresponding structural alteration, we examined brain function and structure in these participants as well as in a group of healthy controls using multimodal MRI. The data were analyzed using statistical parametric mapping. Results We included 24 participants in the FEP group, 18 in the UHR group and 21 in the control group. Patients in the FEP group showed a reduction in functional activation in the left superior temporal gyrus relative to controls, and the UHR group showed intermediate values. The same region showed a corresponding reduction in grey matter volume in the FEP group relative to controls. However, while the difference in grey matter volume remained significant after including functional activation as a covariate of no interest, the reduction in functional activation was no longer evident after including grey matter volume as a covariate of no interest. Limitations Our sample size was relatively small. All participants in the FEP group and 2 in the UHR group had received antipsychotic medication, which may have impacted neurofunction and/or neuroanatomy. Conclusion Our results suggest that superior temporal dysfunction in early psychosis is accounted for by a corresponding alteration in grey matter volume. This finding has important implications for the interpretation of functional alteration in early psychosis.
The article investigates the difficult and controversial landscape of Taranto, a recently industrialised city of southern Italy, which in the last 70 years has undergone dramatic changes. We analyse ...what the landscape is in material, cultural, and symbolic terms, what it does, and what it means in and for Taranto. In particular, by analysing bibliographic, cartographic, and audiovisual sources, we trace the evolution of contemporary Taranto, indicating the main factors which enabled its material transformation during the second half of the twentieth century. Then, we reflect on how the landscape has been shaped in different times and at different scales through dominant narratives and counter-narratives. Finally, we identify specific elements of Taranto's landscape and their symbolic meaning. The study offers a paradigmatic case of a flickering landscape, modified by political forces and cultural constructs.
The concept of ecosystem services (ES) has mainstreamed as an interdisciplinary framework in the urban sustainability and resilience agenda. While the uptake of ES in urban areas is deeply entangled ...with multiple values, trade-offs, institutions, management and planning approaches, there is still a lack of a comprehensive and systematic framework to address environmental justice (EJ) in urban ES assessments. This article presents a systematic literature review to examine what factors are critical for the effective inclusion of an EJ lens in urban ES appraisals. More specifically, we assessed how distributional, procedural and recognitional EJ dimensions have been addressed, and in relation to which types of urban ES. Our results reveal that EJ considerations are currently focused on the (un)equal distribution of ES and the associated green and blue infrastructure with regard to socioeconomic groups, with special attention to income and race/ethnicity as the main mechanisms of social stratification. There is also a predominant focus on regulating and cultural ES, analyzing their role on resilience and adaptive capacity on one hand, and recreational values, social cohesion and place-making on the other. In this review, we also evaluate the interconnected dimensions of justice and their constraints, and lay out pathways for new research into intersectional and restorative approaches to justice in ES assessments. Finally, we interrogate what the role of urban ES-based planning might be in making more inclusive and just cities and explore its implications for policy and practice.
Our paper aims at widening political ecology research on business' responsibility and public governance conditions in cases of violation of Environmental-related Human Rights (ERs), by adopting a ...quantitative perspective. We focused on a subset of socio-environmental conflicts (SECs) that directly connect with the violations of ERs. We propose a quali-quantitative analysis to explore the country distribution of the incidence of violations of ERs leading to SECs (VERCs) worldwide; the extent to which these can be associated with the involvement of business companies; and the general governance conditions spatially associated with the emergence of VERCs, regardless of the involvement of businesses. Through statistical regression analysis, we showed that the evidence of business' implication in VERCs and of the lack of adequate public governance conditions suggest the need to complexify our perspective with a more nuanced understanding of the patterns of liability and complicity between diverse actors involved in SECs.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is responsible for the first pandemic of the 21st century. As found in ...adults, signs and symptoms related to the disease mainly involve the respiratory tract in the paediatric population. However, a considerable number of children present with gastrointestinal symptoms such as vomiting, abdominal pain, and diarrhea. The purpose of this review is an accurate description, from pathogenesis to clinical presentation, diagnosis and treatment, of COVID-19 effects on the gastrointestinal system at a paediatric age. SARS-CoV-2 can be identified in stool specimens of affected children by real-time polymerase chain reaction techniques. Positivity can last for several weeks after the end of the symptomatic phase. Gastrointestinal signs and symptoms are generally self-limited, can correlate with blood tests and imaging alterations, and may require supportive treatment such as hydration. However, they can precede severe disease manifestations such as the COVID-19-related multisystem inflammatory syndrome. Children belonging to risk categories such as those affected by celiac disease, inflammatory bowel disease, and hepatic disease seem to not have a more severe course than the others, even if they are undergoing immunosuppressant treatment. Medical follow-ups of patients with chronic diseases need to be revised during the pandemic period in order to postpone unnecessary tests, mainly endoscopic ones.
Synesthesia represents an atypical merging of percepts, in which a given sensory experience (e.g., words, letters, music) triggers sensations in a different perceptual domain (e.g., color). According ...to recent estimates, the vast majority of the reported cases of synesthesia involve a visual experience. Purely non-visual synesthesia is extremely rare and to date there is no reported case of a congenitally blind synesthete. Moreover, it has been suggested that congenital blindness impairs the emergence of synesthesia-related phenomena such as multisensory integration and cross-modal correspondences between non-visual senses (e.g., sound-touch). Is visual experience necessary to develop synesthesia? Here we describe the case of a congenital blind man (CB) reporting a complex synesthetic experience, involving numbers, letters, months and days of the week. Each item is associated with a precise position in mental space and with a precise tactile texture. In one experiment we empirically verified the presence of number-texture and letter-texture synesthesia in CB, compared to non-synesthete controls, probing the consistency of item-texture associations across time and demonstrating that synesthesia can develop without vision. Our data fill an important void in the current knowledge on synesthesia and shed light on the mechanisms behind sensory crosstalk in the human mind.
•Synesthesia affects about 3–4% of the population and has been extensively studied.•The majority of the cases of synesthesia involve visual experience.•Congenital blindness may impair the development of sensory cross-talk.•We report the case of a synesthetic congenital blind man.•Synesthesia can develop without vision.
Neuroplasticity following sensory deprivation has long inspired neuroscience research in the quest of understanding how sensory experience and genetics interact in developing the brain functional and ...structural architecture. Many studies have shown that sensory deprivation can lead to cross-modal functional recruitment of sensory deprived cortices. Little is known however about how structural reorganization may support these functional changes. In this study, we examined early deaf, hearing signer and hearing non-signer individuals using diffusion MRI to evaluate the potential structural connectivity linked to the functional recruitment of the temporal voice area by face stimuli in deaf individuals. More specifically, we characterized the structural connectivity between occipital, fusiform and temporal regions typically supporting voice- and face-selective processing. Despite the extensive functional reorganization for face processing in the temporal cortex of the deaf, macroscopic properties of these connections did not differ across groups. However, both occipito- and fusiform-temporal connections showed significant microstructural changes between groups (fractional anisotropy reduction, radial diffusivity increase). We propose that the reorganization of temporal regions after early auditory deprivation builds on intrinsic and mainly preserved anatomical connectivity between functionally specific temporal and occipital regions.
•Macrostructural connectivity of the face-voice system is preserved in early deafness.•Early deafness impacts on the microstructural connectivity of the face-voice system.•Both genetics and experience shape structural connections in the face-voice system.•Innate anatomical networks might constrain the expression of cross-modal plasticity.
Aim. To provide bone status assessment in infancy using quantitative ultrasound (QUS) applied to second metacarpus. Methods. 103 healthy term infants and 3 patients with rickets, aged ≤ 12 months, ...underwent metacarpal QUS evaluation using QUS DBM Sonic Aurora IGEA (MO, Italy), which measures speed of sound (mcSOS) and bone transmission time (mcBTT). Results. In the total sample, median (interquartile range) of mcSOS was 1640.00 (26.0) m/s and mcBTT 0.82 (0.21) µs. Moreover, reference values for age were obtained based on estimation of the lower and upper percentiles. We observed a statistical significant difference between groups of age for mcSOS (p = 0.016). In a multiple linear regression model, we found a relation between age at enrolment and mcSOS (β = -0.608; p = 0.000) and mcBTT (β = -0.819; p = 0.001). A positive correlation between mcSOS and mcBTT has been observed (r = 0.631; p = 0.000). All the patients with rickets showed values of mcSOS and mcBTT lower than the 10th percentile. Conclusion. Our findings show that this new simple technique appears to be a promising tool for monitoring bone mineral status in pediatric clinical practice and in early life. Furthermore, it could be considered a useful method to investigate and to monitor the role of different factors on programming of bone health and it should be tested as a new method for monitoring subjects with rickets during therapy.
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