Background: Occult lymph node (LN) metastases are clinically relevant and confer a worse prognosis in non-small-cell lung cancer (NSCLC) patients. Current staging methods are unable to identify ...patients with poor outcome. Their detection requires both a more sensitive and specific technique. We aimed to assess the role of messenger RNA expression in pathologically negative LNs (pN0) of stage I NSCLC patients as markers of occult micrometastases and to correlate the results with local or distant tumor recurrence and survival.
Patients and methods: Potential molecular markers were evaluated in 344 LNs and 38 tumors by quantitative real-time RT-PCR. Only CEACAM5 and PLUNC showed high expression in lung tumor tissue and null expression in RNA from benign LNs.
Results: Thirteen per cent of the LNs were positive for CEACAM5 and 16% for PLUNC. Eight of 38 NSCLC patients had positive expression in pN2 nodes by CEACAM5 and/or PLUNC and disease-free survival (P=0.028) and overall survival time was significantly worse in these patients compared with those with negative expression (P=0.0083).
Conclusions: Quantitative real-time RT-PCR of CEACAM5 and PLUNC can estimate the presence of micrometastatic cells in LNs with greater precision than current staging method used for assessing tumor recurrence risk.
A
bstract
Natural radioactivity represents one of the main backgrounds in the search for neutrinoless double beta decay. Within the NEXT physics program, the radioactivity- induced backgrounds are ...measured with the NEXT-White detector. Data from 37.9 days of low-background operations at the Laboratorio Subterráneo de Canfranc with xenon depleted in
136
Xe are analyzed to derive a total background rate of (0.84
±
0.02) mHz above 1000 keV. The comparison of data samples with and without the use of the radon abatement system demonstrates that the contribution of airborne-Rn is negligible. A radiogenic background model is built upon the extensive radiopurity screening campaign conducted by the NEXT collaboration. A spectral fit to this model yields the specific contributions of
60
Co,
40
K,
214
Bi and
208
Tl to the total background rate, as well as their location in the detector volumes. The results are used to evaluate the impact of the radiogenic backgrounds in the double beta decay analyses, after the application of topological cuts that reduce the total rate to (0.25
±
0.01) mHz. Based on the best-fit background model, the NEXT-White median sensitivity to the two-neutrino double beta decay is found to be 3.5
σ
after 1 year of data taking. The background measurement in a Q
ββ
±
100 keV energy window validates the best-fit background model also for the neutrinoless double beta decay search with NEXT-100. Only one event is found, while the model expectation is (0.75
±
0.12) events.
A
bstract
Excellent energy resolution is one of the primary advantages of electroluminescent high-pressure xenon TPCs. These detectors are promising tools in searching for rare physics events, such ...as neutrinoless double-beta decay (
ββ
0
ν
), which require precise energy measurements. Using the NEXT-White detector, developed by the NEXT (Neutrino Experiment with a Xenon TPC) collaboration, we show for the first time that an energy resolution of 1% FWHM can be achieved at 2.6 MeV, establishing the present technology as the one with the best energy resolution of all xenon detectors for
ββ
0
ν
searches.
A
bstract
In experiments searching for neutrinoless double-beta decay, the possibility of identifying the two emitted electrons is a powerful tool in rejecting background events and therefore ...improving the overall sensitivity of the experiment. In this paper we present the first measurement of the efficiency of a cut based on the different event signatures of double and single electron tracks, using the data of the NEXT-White detector, the first detector of the NEXT experiment operating underground. Using a
228
Th calibration source to produce signal-like and background-like events with energies near 1.6 MeV, a signal efficiency of 71
.
6
±
1
.
5
stat
±
0
.
3
sys
% for a background acceptance of 20
.
6
±
0
.
4
stat
±
0
.
3
sys
% is found, in good agreement with Monte Carlo simulations. An extrapolation to the energy region of the neutrinoless double beta decay by means of Monte Carlo simulations is also carried out, and the results obtained show an improvement in background rejection over those obtained at lower energies.
A
bstract
The NEXT experiment aims at searching for the hypothetical neutrinoless double-beta decay from the
136
Xe isotope using a high-purity xenon TPC. Efficient discrimination of the events ...through pattern recognition of the topology of primary ionisation tracks is a major requirement for the experiment. However, it is limited by the diffusion of electrons. It is known that the addition of a small fraction of a molecular gas to xenon reduces electron diffusion. On the other hand, the electroluminescence (EL) yield drops and the achievable energy resolution may be compromised. We have studied the effect of adding several molecular gases to xenon (CO
2
, CH
4
and CF
4
) on the EL yield and energy resolution obtained in a small prototype of driftless gas proportional scintillation counter. We have compared our results on the scintillation characteristics (EL yield and energy resolution) with a microscopic simulation, obtaining the diffusion coefficients in those conditions as well. Accordingly, electron diffusion may be reduced from about 10 mm/
m
for pure xenon down to 2.5 mm/
m
using additive concentrations of about 0.05%, 0.2% and 0.02% for CO
2
, CH
4
and CF
4
, respectively. Our results show that CF
4
admixtures present the highest EL yield in those conditions, but very poor energy resolution as a result of huge fluctuations observed in the EL formation. CH
4
presents the best energy resolution despite the EL yield being the lowest. The results obtained with xenon admixtures are extrapolated to the operational conditions of the NEXT-100 TPC. CO
2
and CH
4
show potential as molecular additives in a large xenon TPC. While CO
2
has some operational constraints, making it difficult to be used in a large TPC, CH
4
shows the best performance and stability as molecular additive to be used in the NEXT-100 TPC, with an extrapolated energy resolution of 0.4% at 2.45 MeV for concentrations below 0.4%, which is only slightly worse than the one obtained for pure xenon. We demonstrate the possibility to have an electroluminescence TPC operating very close to the thermal diffusion limit without jeopardizing the TPC performance, if CO
2
or CH
4
are chosen as additives.
A
bstract
The measurement of the internal
222
Rn activity in the NEXT-White detector during the so-called Run-II period with
136
Xe-depleted xenon is discussed in detail, together with its ...implications for double beta decay searches in NEXT. The activity is measured through the alpha production rate induced in the fiducial volume by
222
Rn and its alpha-emitting progeny. The specific activity is measured to be (38.1 ± 2.2 (stat.) ± 5.9 (syst.)) mBq/m
3
. Radon-induced electrons have also been characterized from the decay of the
214
Bi daughter ions plating out on the cathode of the time projection chamber. From our studies, we conclude that radon-induced backgrounds are sufficiently low to enable a successful NEXT-100 physics program, as the projected rate contribution should not exceed 0.1 counts/yr in the neutrinoless double beta decay sample.
In this work we present the energy and spatial resolutions we have obtained for a γ-ray detector based on a monolithic LYSO crystal coupled to an array of 256 SiPMs. Two crystal configurations of the ...same trapezoidal shape have been tried. In one approach all surfaces were black painted but the exit one facing the photosensor array which was polished. The other approach included a retroreflector (RR) layer coupled to the entrance face of the crystal powering the amount of transmitted light to the photosensors. Two coupling media between the scintillator and the SiPM array were used, namely direct coupling by means of optical grease and coupling through an array of light guides. Since the same operational voltage was supplied to the entire array, it was needed to equalize their gains before feeding their signals to the Data Acquisition system. Such a job was performed by means of 4 scalable Application Specific Circuits (ASICs). An energy resolution of about 24.4% has been achieved for the direct coupling with the RR layer together with a spatial resolution of approximately 2.9mm at the detector center. With the light guides coupling the effects of image compression at the edges are significantly minimized, but worsening the energy resolution to about 33.1% with a spatial resolution nearing 4mm at the detector center.
In Positron Emission Tomography (PET) detectors based on monolithic scintillators, the photon interaction position needs to be estimated from the light distribution (LD) on the photodetector pixels. ...Due to the finite size of the scintillator volume, the symmetry of the LD is truncated everywhere except for the crystal center. This effect produces a poor estimation of the interaction positions towards the edges, an especially critical situation when linear algorithms, such as Center of Gravity (CoG), are used. When all the crystal faces are painted black, except the one in contact with the photodetector, the LD can be assumed to behave as the inverse square law, providing a simple theoretical model. Using this LD model, the interaction coordinates can be determined by means of fitting each event to a theoretical distribution. In that sense, the use of neural networks (NNs) has been shown to be an effective alternative to more traditional fitting techniques as nonlinear least squares (LS). The multilayer perceptron is one type of NN which can model non-linear functions well and can be trained to accurately generalize when presented with new data. In this work we have shown the capability of NNs to approximate the LD and provide the interaction coordinates of γ-photons with two different photodetector setups. One experimental setup was based on analog Silicon Photomultipliers (SiPMs) and a charge division diode network, whereas the second setup was based on digital SiPMs (dSiPMs). In both experiments NNs minimized border effects. Average spatial resolutions of 1.9 ±0.2 mm and 1.7 ±0.2 mm for the entire crystal surface were obtained for the analog and dSiPMs approaches, respectively.
We present evidence of non-excimer-based secondary scintillation in gaseous xenon, obtained using both the NEXT-White time projection chamber (TPC) and a dedicated setup. Detailed comparison with ...first-principle calculations allows us to assign this scintillation mechanism to neutral bremsstrahlung (NBrS), a process that is postulated to exist in xenon that has been largely overlooked. For photon emission below 1000 nm, the NBrS yield increases from about10−2photon/e−cm−1bar−1at pressure-reduced electric field values of50Vcm−1bar−1to above3×10−1photon/e−cm−1bar−1at500Vcm−1bar−1. Above1.5kVcm−1bar−1, values that are typically employed for electroluminescence, it is estimated that NBrS is present with an intensity around1photon/e−cm−1bar−1, which is about 2 orders of magnitude lower than conventional, excimer-based electroluminescence. Despite being fainter than its excimeric counterpart, our calculations reveal that NBrS causes luminous backgrounds that can interfere, in either gas or liquid phase, with the ability to distinguish and/or to precisely measure low primary-scintillation signals (S1). In particular, we show this to be the case in the “buffer” region, where keeping the electric field below the electroluminescence threshold does not suffice to extinguish secondary scintillation. The electric field leakage in this region should be mitigated to avoid intolerable levels of NBrS emission. Furthermore, we show that this new source of light emission opens up a viable path toward obtaining S2 signals for discrimination purposes in future single-phase liquid TPCs for neutrino and dark matter physics, with estimated yields up to20–50photons/e−cm−1.
If neutrinos are their own antiparticles the otherwise-forbidden nuclear reaction known as neutrinoless double beta decay can occur. The very long lifetime expected for these exceptional events makes ...its detection a daunting task. In order to conduct an almost background-free experiment, the NEXT collaboration is investigating novel synthetic molecular sensors that may capture the Ba dication produced in the decay of certain Xe isotopes in a high-pressure gas experiment. The use of such molecular detectors immobilized on surfaces must be explored in the ultra-dry environment of a xenon gas chamber. Here, using a combination of highly sensitive surface science techniques in ultra-high vacuum, we demonstrate the possibility of employing the so-called Fluorescent Bicolor Indicator as the molecular component of the sensor. We unravel the ion capture process for these molecular indicators immobilized on a surface and explain the origin of the emission fluorescence shift associated to the ion trapping.
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