Abstract Aim The aim of this study is to evaluate the effectiveness and safety of continuous subcutaneous insulin infusion (CSII) under real-life conditions among all patients treated with CSII in ...the south of Paris. Methods The 42 diabetologists practising in the region enrolled all patients treated with CSII or admitted for CSII initiation. During the study visit, the data for pump use and clinical results were recorded. Results Data were obtained for 424 patients, mean age 44.2 ± 15.6 years, disease duration 18.7 ± 10.6 years, including 339 treated with CSII for longer than three months (mean duration: 3.5 ± 3.5 years; range: 3–258 months). Most of the patients ( N = 285, 84.8%) had type 1 diabetes; 44 (13.1%) had type 2 diabetes. In patients treated for more than three months, HbA1c decreased significantly between CSII initiation (9.1 ± 1.9%) and the study visit (7.8 ± 1.4%; P < 0.0001). Patients with HbA1c > 9%, using the pump, experienced a significant 0.9% improvement in their HbA1c levels with CSII versus multiple daily injections ( P = 0.001). The number of episodes of moderate hypoglycaemia was 2.7 ± 2.5 per patient per week; of severe hypoglycaemia, 0.34 per patient per year and of ketoacidosis, 0.11 per patient per year. Factors significantly associated with HbA1c levels included amount of physical activity, pregnancy, HbA1c at CSII initiation and number of glucose self-determinations. Those associated with the number of moderate hypoglycaemia episodes were basal rate number, female gender and HbA1c level. HbA1c was negatively correlated with moderate hypoglycaemia ( P < 0.001), but not with severe hypoglycaemia. Conclusion This ‘pump’ registry establishes the effectiveness of CSII in everyday practice, yet underscores the risks of severe hypoglycaemia and ketosis episodes. It could help diabetologists to improve patient training programmes and follow-up.
The development and standardization of toxicity test methods for assessing toxicity of contaminated freshwater sediments has focused predominantly on short-term exposures and lethality. In many ...situations, however, toxicity is more likely to become manifest over long periods of time so there is need for standardized testing procedures by which sublethal sediment toxicity can be adequately assessed. In this study, we present and evaluate a new life cycle test, using the midge Chironomus tentans, which enables the assessment of sublethal toxicity of contaminated sediments. In designing the life cycle test, our goal was to make the assay relatively straightforward and, to the extent possible, methodologically compatible with the standard 10-d test. The test is initiated with newly hatched ( 24 h) larvae and uses four effects-based endpoints to assess toxicity: survival, growth, emergence, and reproduction. Survival is determined at 20 d and at the end of the test by back-calculating through emergence data. Growth can be determined at 20 d, which corresponds to the 10-d endpoint in the 10-d C. tentans growth test initiated with 10-d-old larvae. From day 23 to the end of the test, emergence and reproduction are monitored daily. The number of eggs per female is determined for each egg mass, which is then incubated for 6 d to determine hatching success. Each treatment in the life cycle test is terminated separately after 7 consecutive days without emergence. We evaluated the life cycle test by following one generation of C. tentans in sediments collected from the upper Mississippi River. Survival of larvae exceeded 90% at 20 d. Of these larvae, between 60 and 70% successfully emerged: survivorship among pupae and adults exceeded 85%. Mean egg production ranged from 906 to 1,107 eggs per female. The test required 65 d to complete, including pretest preparation. These data show that the C. tentans life cycle test can be used to assess sublethal toxicity accurately in contam
Planck intermediate results Arnaud, M.; Baccigalupi, C.; Balbi, A. ...
Astronomy and astrophysics (Berlin),
02/2013, Letnik:
550
Journal Article
Recenzirano
A comparison is presented of Sunyaev-Zeldovich measurements for 11 galaxy clusters as obtained by Planck and by the ground-based interferometer, the Arcminute Microkelvin Imager. Assuming a universal ...spherically-symmetric Generalised Navarro, Frenk and White (GNFW) model for the cluster gas pressure profile, we jointly constrain the integrated Compton-Y parameter (Y500) and the scale radius (θ500) of each cluster. Our resulting constraints in the Y500 − θ500 2D parameter space derived from the two instruments overlap significantly for eight of the clusters, although, overall, there is a tendency for AMI to find the Sunyaev-Zeldovich signal to be smaller in angular size and fainter than Planck. Significant discrepancies exist for the three remaining clusters in the sample, namely A1413, A1914, and the newly-discovered Planck cluster PLCKESZ G139.59+24.18. The robustness of the analysis of both the Planck and AMI data is demonstrated through the use of detailed simulations, which also discount confusion from residual point (radio) sources and from diffuse astrophysical foregrounds as possible explanations for the discrepancies found. For a subset of our cluster sample, we have investigated the dependence of our results on the assumed pressure profile by repeating the analysis adopting the best-fitting GNFW profile shape which best matches X-ray observations. Adopting the best-fitting profile shape from the X-ray data does not, in general, resolve the discrepancies found in this subset of five clusters. Though based on a small sample, our results suggest that the adopted GNFW model may not be sufficiently flexible to describe clusters universally.
Planck intermediate results Arnaud, M.; Atrio-Barandela, F.; Aumont, J. ...
Astronomy and astrophysics (Berlin),
02/2013, Letnik:
550
Journal Article
Recenzirano
Context. About half of the baryons of the Universe are expected to be in the form of filaments of hot and low-density intergalactic medium. Most of these baryons remain undetected even by the most ...advanced X-ray observatories, which are limited in sensitivity to the diffuse low-density medium. Aims. The Planck satellite has provided hundreds of detections of the hot gas in clusters of galaxies via the thermal Sunyaev-Zel’dovich (tSZ) effect and is an ideal instrument for studying extended low-density media through the tSZ effect. In this paper we use the Planck data to search for signatures of a fraction of these missing baryons between pairs of galaxy clusters. Methods. Cluster pairs are good candidates for searching for the hotter and denser phase of the intergalactic medium (which is more easily observed through the SZ effect). Using an X-ray catalogue of clusters and the Planck data, we selected physical pairs of clusters as candidates. Using the Planck data, we constructed a local map of the tSZ effect centred on each pair of galaxy clusters. ROSAT data were used to construct X-ray maps of these pairs. After modelling and subtracting the tSZ effect and X-ray emission for each cluster in the pair, we studied the residuals on both the SZ and X-ray maps. Results. For the merging cluster pair A399-A401 we observe a significant tSZ effect signal in the intercluster region beyond the virial radii of the clusters. A joint X-ray SZ analysis allows us to constrain the temperature and density of this intercluster medium. We obtain a temperature of kT = 7.1 ± 0.9 keV (consistent with previous estimates) and a baryon density of (3.7 ± 0.2) × 10-4 cm-3. Conclusions. The Planck satellite mission has provided the first SZ detection of the hot and diffuse intercluster gas.
Planck intermediate results Aghanim, N.; Arnaud, M.; Atrio-Barandela, F. ...
Astronomy and astrophysics (Berlin),
02/2013, Letnik:
550
Journal Article
Recenzirano
Taking advantage of the all-sky coverage and broadfrequency range of the Planck satellite, we study the Sunyaev-Zeldovich (SZ) and pressure profiles of 62 nearby massive clusters detected at high ...significance in the 14-month nominal survey. Careful reconstruction of the SZ signal indicates that most clusters are individually detected at least out to R500. By stacking the radial profiles, we have statistically detected the radial SZ signal out to 3 × R500, i.e., at a density contrast of about 50–100, though the dispersion about the mean profile dominates the statistical errors across the whole radial range. Our measurement is fully consistent with previous Planck results on integrated SZ fluxes, further strengthening the agreement between SZ and X-ray measurements inside R500. Correcting for the effects of the Planck beam, we have calculated the corresponding pressure profiles. This new constraint from SZ measurements is consistent with the X-ray constraints from XMM-Newton in the region in which the profiles overlap (i.e., 0.1–1 R500), and is in fairly good agreement with theoretical predictions within the expected dispersion. At larger radii the average pressure profile is slightly flatter than most predictions from numerical simulations. Combining the SZ and X-ray observed profiles into a joint fit to a generalised pressure profile gives best-fit parameters P0,c500,γ,α,β = 6.41,1.81,0.31,1.33,4.13 . Using a reasonable hypothesis for the gas temperature in the cluster outskirts we reconstruct from our stacked pressure profile the gas mass fraction profile out to 3 R500. Within the temperature driven uncertainties, our Planck constraints are compatible with the cosmic baryon fraction and expected gas fraction in halos.
Planck intermediate results Arnaud, M.; Baccigalupi, C.; Balbi, A. ...
Astronomy and astrophysics (Berlin),
02/2013, Letnik:
550
Journal Article
Recenzirano
We present the final results from the XMM-Newton validation follow-up of new Planck galaxy cluster candidates. We observed 15 new candidates, detected with signal-to-noise ratios between 4.0 and 6.1 ...in the 15.5-month nominal Planck survey. The candidates were selected using ancillary data flags derived from the ROSAT All Sky Survey (RASS) and Digitized Sky Survey all-sky maps, with the aim of pushing into the low SZ flux, high-z regime and testing RASS flags as indicators of candidate reliability. Fourteen new clusters were detected by XMM-Newton, ten single clusters and two double systems. Redshifts from X-ray spectroscopy lie in the range 0.2 to 0.9, with six clusters at z > 0.5. Estimated masses (M500) range from 2.5 × 1014 to 8 × 1014 M⊙. We discuss our results in the context of the full XMM-Newton validation programme, in which 51 new clusters have been detected. This includes four double and two triple systems, some of which are chance projections on the sky of clusters at different redshifts. We find thatassociation with a source from the RASS-Bright Source Catalogue is a robust indicator of the reliability of a candidate, whereas association with a source from the RASS-Faint Source Catalogue does not guarantee that the SZ candidate is a bona fide cluster. Nevertheless, most Planck clusters appear in RASS maps, with a significance greater than 2σ being a good indication that the candidate is a real cluster. Candidate validation from association with SDSS galaxy overdensity at z > 0.5 is also discussed. The full sample gives a Planck sensitivity threshold of Y500 ~ 4 × 10-4 arcmin2, with indication for Malmquist bias in the YX–Y500 relation below this threshold. The corresponding mass threshold depends on redshift. Systems with M500 > 5 × 1014 M⊙ at z > 0.5 are easily detectable with Planck. The newly-detected clusters follow the YX–Y500 relation derived from X-ray selected samples. Compared to X-ray selected clusters, the new SZ clusters have a lower X-ray luminosity on average for their mass. There is no indication of departure from standard self-similar evolution in the X-ray versus SZ scaling properties. In particular, there is no significant evolution of the YX/Y500 ratio.
Planck intermediate results Arnaud, M.; Atrio-Barandela, F.; Aumont, J. ...
Astronomy and astrophysics (Berlin),
02/2013, Letnik:
550
Journal Article
Recenzirano
The survey of galaxy clusters performed by Planck through the Sunyaev-Zeldovich effect has already discovered many interesting objects, thanks to its full sky coverage. One of the SZcandidates ...detected in the early months of the mission near to the signal-to-noise threshold, PLCKG214.6+37.0, was later revealed by XMM-Newton to be a triple system of galaxy clusters. We present the results from a deep XMM-Newton re-observation of PLCKG214.6+37.0, part of a multi-wavelength programme to investigate Planck discovered superclusters. The characterisation of the physical properties of the three components has allowed us to build a template model to extract the total SZ signal of this system with Planck data. We have partly reconciled the discrepancy between the expected SZ signal derived from X-rays and the observed one, which are now consistent within 1.2σ. We measured the redshift of the three components with the iron lines in the X-ray spectrum, and confirm that the three clumps are likely part of the same supercluster structure. The analysis of the dynamical state of the three components, as well as the absence of detectable excess X-ray emission, suggests that we are witnessing the formation of a massive cluster at an early phase of interaction.
Mode-selective multicore fibre photonic lanterns are used to create a 6-mode multimode optical fibre link that is considerably more resistant to focal ratio degradation (FRD) than a 6-mode step-index ...optical fibre.
the territorial actor is the daily craftsman of his cultural space. The need for a continuity of the endogenous exchange is one of the values on which is built the territorial historical account. We ...will examine them pre-necessary of this sometimes asymmetrical relation and will propose using what we will call a grid of reading "the metaphor of the staircase".
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