This volume argues that international human rights law has made a positive contribution to the realization of human rights in much of the world. Although governments sometimes ratify human rights ...treaties, gambling that they will experience little pressure to comply with them, this is not typically the case. Focusing on rights stakeholders rather than the United Nations or state pressure, Beth Simmons demonstrates through a combination of statistical analyses and case studies that the ratification of treaties leads to better rights practices on average. Simmons argues that international human rights law should get more practical and rhetorical support from the international community as a supplement to broader efforts to address conflict, development, and democratization.
How Taxol/paclitaxel kills cancer cells Weaver, Beth A
Molecular biology of the cell,
2014-Sep-15, 2014-09-15, 20140915, Letnik:
25, Številka:
18
Journal Article
Recenzirano
Odprti dostop
Taxol (generic name paclitaxel) is a microtubule-stabilizing drug that is approved by the Food and Drug Administration for the treatment of ovarian, breast, and lung cancer, as well as Kaposi's ...sarcoma. It is used off-label to treat gastroesophageal, endometrial, cervical, prostate, and head and neck cancers, in addition to sarcoma, lymphoma, and leukemia. Paclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of the arrested population. However, recent evidence demonstrates that intratumoral concentrations of paclitaxel are too low to cause mitotic arrest and result in multipolar divisions instead. It is hoped that this insight can now be used to develop a biomarker to identify the ∼50% of patients that will benefit from paclitaxel therapy. Here I discuss the history of paclitaxel and our recently evolved understanding of its mechanism of action.
Senegalese Murid migrants have circulated cargo and currency through official and unofficial networks in Africa and the world. Muslim Families in Global Senegal focuses on trade and the transmission ...of enduring social value though cloth, videos of life-cycle rituals, and religious offerings. Highlighting women's participation in these networks and the financial strategies they rely on, Beth Buggenhagen reveals the deep connections between economic profits and ritual and social authority. Buggenhagen discovers that these strategies are not responses to a dispersed community in crisis, but rather produce new roles, wealth, and worth for Senegalese women in all parts of the globe.
The diffusion of markets and democracy around the world was a defining feature of the late twentieth century. Many social scientists view this economic and political liberalization as the product of ...independent choices by national governments. This book argues that policy and political changes were influenced heavily by prior actions of external actors: not just other governments, but international organizations and communities of experts. Drawing together insights from economics, sociology, political science and international relations, the contributors focus on four mechanisms by which markets and democracy have diffused through interdependent decision-making: coercion and the impact of powerful countries and international actors; economic competition for markets and investment; learning from experiences of other countries; and emulation among countries. These mechanisms are tested empirically using sophisticated quantitative techniques in areas as diverse as capital account and investment policy, human rights and democratization, and government downsizing, privatization and taxation.
Unprecedented advances have been made in cancer treatment with the use of immune checkpoint blockade (ICB). However, responses are limited to a subset of patients, and immune-related adverse events ...(irAEs) can be problematic, requiring treatment discontinuation. Iterative insights into factors intrinsic and extrinsic to the host that impact ICB response and toxicity are critically needed. Our understanding of the impact of host-intrinsic factors (such as the host genome, epigenome, and immunity) has evolved substantially over the past decade, with greater insights on these factors and on tumor and immune co-evolution. Additionally, we are beginning to understand the impact of acute and cumulative exposures—both internal and external to the host (i.e., the exposome)—on host physiology and response to treatment. Together these represent the current day hallmarks of response, resistance, and toxicity to ICB. Opportunities built on these hallmarks are duly warranted.
Immune checkpoint blockade has revolutionized cancer therapeutics, but it doesn’t work for everyone. It may cause unacceptable immune-related adverse events, or tumors may fail to respond or develop resistance. We’re beginning to understand the biological reasons why.
A common idea in the discussion of soil carbon processes is that litter decomposition rates and soil carbon stocks are inversely related. To test this overall hypothesis, simultaneous studies were ...conducted of the relationship of environmental gradients to leaf and wood decomposition, buried cloth decomposition and percent soil organic matter in Taxodium distichum swamps across the Mississippi River Alluvial Valley (MRAV) and northern Gulf of Mexico (GOM) of the US. Decomposition of leaf tissue was 6.2 to 10.9 times faster than wood tissue. Both precipitation and flooding gradients were negatively related to leaf and wood litter decomposition rates based on models developed using Stepwise General Model Selection (MRAV vs. GOM, respectively). Cotton cloth should not be used as a proxy for plant litter without prior testing because cloth responded differently than plant litter to regional environmental gradients in T. distichum swamps. The overall hypothesis was supported in the MRAV because environments with higher precipitation (climate normal) had lower rates of decomposition and higher percent soil organic matter. In the MRAV, higher levels of percent soil organic matter were related to increased 30-year climate normals (30 year averages of precipitation and air temperature comprising southward increasing PrinComp1). Soil organic carbon % in inland vs. coastal T. distichum forests of the MRAV were comparable (range = 1.5% to 26.9% vs. 9.8 to 31.5%, respectively). GOM swamps had lower rates of litter decomposition in more flooded environments. Woody T. distichum detritus had a half-life of up to 300 years in the MRAV, which points to its likely role in the maintenance of inland "teal" soil organic carbon. This unique study can contribute to the discussion of approaches to maintain environments conducive to soil carbon stock maximization.
Most studies of technologies’impact on occupational change focus on occupational groups’ adoption and use of particular technologies in a field or workplace. Drawing on an 18-month ethnographic study ...of a crime laboratory, I focus instead on “evaluative spillovers”: the comparisons that occupations encounter when technologies change the work of neighboring occupations in their field. I explore what happened when DNA profiling was held up as the “gold standard” of forensic evidence, resulting in scientific, public, and legal scrutiny of other forensic science occupational groups. Comparisons with DNA profiling challenged the working techniques and the values of firearms examiners, toxicologists, and narcotics analysts, but each group responded differently, either embracing or resisting changes to their work practices. Their responses were predicated on the institutional pathways that evaluative spillovers traveled through the field in locales such as professional association meetings and court proceedings. These three aspects of the occupational system—technique, values, and institutional pathways—influenced how workers negotiated the impact of technological change in the field of forensic science.
The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with ...evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.
The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.
This book tells the stories of disabled people who have been influential in creating modern mass media. Through the voices of key disabled media makers and collaborators, the author highlights the ...ways in which their contributions are changing society’s understanding of disability and shaping mass media and culture. Spanning a range of media formats – television/streaming productions, performances, podcasts, TED Talks, films, reality TV, graphic novels, and social media channels – the book illustrates how disabled people are confronting the marginalization they have faced in mass media for decades. Modern disabled media creators are leveraging new media platforms to recognize the lived experiences of disability and their authentic place in media culture. This innovative and thought-provoking volume will be an important read for scholars, disability advocates, and students of Disability Studies, Mass Communication/Media Studies, as well as mass media production faculty, disabled people, and their allies The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.
Abstract
Daylight saving time (DST) refers to the practice of advancing clock time by 1 h each spring, with a return (setting back) to standard time (ST) each fall. Numerous sleep and circadian ...societies other than the Sleep Research Society have published statements in support of permanent ST, and permanent ST has also received support from multiple medical societies and organizations. This perspective discusses the positive and negative health and economic consequences of permanent DST, permanent ST, and maintaining the status quo (DST for part of the year). After a thorough review of the existing literature, the SRS advocates the adoption of permanent ST.
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