Abstract
We conduct a spectropolarimetric study of the accreting X-ray pulsar Hercules X-1 using observations with the Imaging X-ray Polarimetry Explorer (IXPE). IXPE monitored the source in three ...different epochs, sampling two “Main-on” and one “Short-on” state of the well-known super-orbital period of the source. We find that the 2–7 keV polarization fraction increases significantly from ∼7% to 9% in the Main-on state to ∼15%–19% in the Short-on state, while the polarization angle remains more or less constant or changes slightly, ∼47°–59°, in all three epochs. The polarization degree and polarization angle are consistent with being energy independent for all three epochs. We propose that in the Short-on state, when the neutron star is partially blocked by the disk warp, the increase in the polarization fraction can be explained as a result of the preferential obstruction of one of the magnetic poles of the neutron star.
ABSTRACT
An understanding of spin frequency (ν) evolution of neutron stars in the low-mass X-ray binary (LMXB) phase is essential to explain the observed ν-distribution of millisecond pulsars (MSPs), ...and to probe the stellar and binary physics, including the possibility of continuous gravitational wave emission. Here, using numerical computations we conclude that ν can evolve in two distinctly different modes, as ν may approach a lower spin equilibrium value (νeq,per) for persistent accretion for a long-term average accretion rate ($\dot{M}_{\rm av}$) greater than a critical limit ($\dot{M}_{\rm av,crit}$), and may approach a higher effective spin equilibrium value (νeq,eff) for transient accretion for $\dot{M}_{\rm av} \lt \dot{M}_{\rm av,crit}$. For example, when $\dot{M}_{\rm av}$ falls below $\dot{M}_{\rm av,crit}$ for an initially persistent source, ν increases considerably due to transient accretion, which is counter-intuitive. We also find that, contrary to what was suggested, a fast or sudden decrease of $\dot{M}_{\rm av}$ to zero in the last part of the LMXB phase is not essential for the genesis of spin-powered MSPs, and neutron stars could spin-up in this $\dot{M}_{\rm av}$-decreasing phase. Our findings imply that the traditional way of ν-evolution computation is inadequate in most cases, even for initially persistent sources, and may not even correctly estimate whether ν increases or decreases.
Silymarin (SMN) has been shown to possess a wide range of biological and pharmacological effects. Besides, SMN has antioxidant and free radical scavenging activities. Thioacetamide (TAA) is a ...well-documented liver toxin that requires oxidative bioactivation to elicit its hepatotoxic effect which ultimately modifies amine-lipids and proteins. Our study has been designed in a TAA exposed mouse model to investigate whether SMN could protect TAA-induced oxidative stress mediated hepatic and renal damage. Results suggest that TAA generated reactive oxygen species (ROS), caused oxidative stress and induced apoptosis in the liver and kidney cells via JNK as well as PKC and MAPKs signaling. All these detrimental effects of TAA could, however, be suppressed by SMN which not only scavenged ROS but also induced PI3K-Akt cell survival pathway in the liver and prevented apoptotic pathways in both the organs. Histological studies, collagen staining and DNA fragmentation analysis also supported our results. Combining, we say that SMN possess beneficial role against TAA mediated hepatic and renal pathophysiology.
An analytical method was developed by using LC-ESI(−ve)-MS/MS to investigate the residue dynamics of 2,4-D (2,4-dichlorophenoxyacetic acid) in green tea leaves, processed tea, tea liquor, and ...tea-cropped soil at Singhiajhora Tea Estate and Putinbari Tea Estate at Terai Region, Darjeeling District, West Bengal, India. In this method, an acidified methanol was used for extraction and subsequent clean-up was done by HLB (hydrophilic lipophilic balanced) cartridges. The method was validated as per SANTE guideline (SANTE/11813/2017). The limit of quantification (LOQ) of 2,4-D was 0.05 mgkg
−1
and average % recoveries were in the range from 88.05 to 113.28 with relative standard deviation (RSD) 3.46 to 6.43. The dissipation of 2,4-D followed the 1st-order reaction kinetics with a half-life (
T
1/2
) of 1.51–1.61 day at the recommended dose and 2.50–2.72 day for doubled recommended dose in tea for both locations. This method can be applied successfully for the determination of 2,4 D residues in/on tea matrix and subsequent studies on safety evaluation showed that the use of 2,4-D in tea is safe.
It is usually thought that a single equation of state (EoS) model "correctly" represents cores of all compact stars. Here we emphasize that two families of compact stars, viz., neutron stars and ...strange stars, can coexist in nature, and that neutron stars can get converted to strange stars through the nucleation process of quark matter in the stellar center. From our fully general relativistic numerical computations of the structures of fast-spinning compact stars, known as millisecond pulsars, we find that such a stellar conversion causes a simultaneous spin-up and decrease in gravitational mass of these stars. This is a new type of millisecond pulsar evolution through a new mechanism, which gives rise to relatively lower mass compact stars with higher spin rates. This could have an implication for the observed mass and spin distributions of millisecond pulsars. Such a stellar conversion can also rescue some massive, spin-supported millisecond pulsars from collapsing into black holes. Besides, we extend the concept of critical mass for the neutron star sequence to the case of fast-spinning neutron stars, and point out that neutron star EoS models cannot be ruled out by the stellar mass measurement alone. Finally, we emphasize the additional complexity for constraining EoS models, for example, by stellar radius measurements using X-ray observations, if two families of compact stars coexist.
Cytochrome monooxygenases P450 enzymes (CYPs) are terminal oxidases, belonging to the multi-gene family of heme-thiolate enzymes and located in multiple sites of ER, cytosol and mitochondria. CYPs ...act as catalysts in drugs metabolism.
This review highlights the mitochondrial and microsomal CYPs metabolic functions, CYPs mediated ROS generation and its feedback, bioactivation of drugs and related hypersensitivity, metabolic disposition as well as the therapeutic approaches.
CYPs mediated drugs bioactivation may trigger oxidative stress and cause pathophysiology. Almost all drugs show some adverse reactions at high doses or accidental overdoses. Drugs lead to hypersensitivity reactions while metabolic predisposition to drug hypersensitivity exaggerates it. Mostly different intermediate bioactive products of CYPs mediated drug metabolism is the principal issue in this respect. On the other hand, CYPs are the main source of ROS. Their generation and feedback are of major concern of this review. Besides drug metabolism, CYPs also contribute significantly to carcinogen metabolism. Ultimately other enzymes in drug metabolism and antioxidant therapy are indispensible. Importance of this field: In a global sense, understanding of exact mechanism can facilitate pharmaceutical industries' challenge of developing drugs without toxicity. Ultimate message: This review would accentuate the recent advances in molecular mechanism of CYPs mediated drug metabolism and complex cross-talks between various restorative novel strategies evolved by CYPs to sustain the redox balance and limit the source of oxidative stress.
A number of neutron star low-mass X-ray binaries (LMXBs) have recently been discovered to show broad, asymmetric Fe K emission lines in their X-ray spectra. These lines are generally thought to be ...the most prominent part of a reflection spectrum, originating in the inner part of the accretion disk where strong relativistic effects can broaden emission lines. We present a comprehensive, systematic analysis of Suzaku and XMM-Newton spectra of 10 neutron star LMXBs, all of which display broad Fe K emission lines. Of the 10 sources, 4 are Z sources, 4 are atolls, and 2 are accreting millisecond X-ray pulsars (also atolls). The Fe K lines are fit well by a relativistic line model for a Schwarzschild metric, and imply a narrow range of inner disk radii (6-15 GM/c {sup 2}) in most cases. This implies that the accretion disk extends close to the neutron star surface over a range of luminosities. Continuum modeling shows that for the majority of observations, a blackbody component (plausibly associated with the boundary layer) dominates the X-ray emission from 8 to 20 keV. Thus it appears likely that this spectral component produces the majority of the ionizing flux that illuminates the accretion disk. Therefore, we also fit the spectra with a blurred reflection model, wherein a blackbody component illuminates the disk. This model fits well in most cases, supporting the idea that the boundary layer illuminates a geometrically thin disk.
Aspirin has been used for a long time as an analgesic and anti-pyretic drug. Limitations of its use, however, remain for the gastro-intestinal side effects and erosions. Although the role of aspirin ...on gastro-intestinal injury has been extensively studied, the molecular mechanisms underlying aspirin-induced liver and spleen pathophysiology are poorly defined. The present study has been conducted to investigate whether phyllanthus niruri protein (PNP) possesses any protective role against aspirin mediated liver and spleen tissue toxicity, and if so, what signaling pathways it utilizes to convey its protective action. Aspirin administration in mice enhanced serum marker (ALP) levels, reactive oxygen species (ROS) generation, reduced antioxidant power and altered oxidative stress related biochemical parameters in liver and spleen tissues. Moreover, we observed that aspirin intoxication activated both the extrinsic and intrinsic apoptotic pathways, as well as down regulated NF-κB activation and the phosphorylation of p38 and JNK MAPKs. Histological assessments and TUNEL assay also supported that aspirin induced tissue damages are apoptotic in nature. PNP treatment after aspirin exposure effectively neutralizes all these abnormalities via the activation of survival PI3k/Akt pathways. Combining all results suggest that PNP could be a potential protective agent to protect liver and spleen from the detrimental effects of aspirin.
A liquid–liquid extraction (LLE) method was validated as per SANTE/12682/2019 guidelines for gas chromatography–mass spectrometric (GC–MS) determination of thirty-six multiclass pesticides in ...environmental waters. Seasonal (summer, monsoon, and winter) effects on the magnitude of pesticide residues in environmental water (river, pond, and tube well) of six different urban areas of Nadia and North 24 Parganas districts (New alluvial zone, Eastern India) was monitored for subsequent risk assessment. Total 288 water samples (96 each of river, pond, and tube-well) irrespective of locations and seasons were monitored for multiclass multi pesticide residues during the experiment. Each sample (750 mL) was extracted with ethyl acetate/dichloromethane (8:2) liquid–liquid partitioning and filtration (0.22 μm nylon filter paper) and total residue was reconstituted in acetone (1 mL) for GC–MS analysis with developed and validated method resulting satisfactory recovery percentages (77.84–118.15%). The maximum no. of organochlorine (OC) and organophosphorus (OP) pesticide residues were dominated in river and pond water irrespective of seasons and monitoring sites. About 74% of river water samples were found to be contaminated with concerned pesticides in variable magnitudes. Monsoon (July to October) season was highly alarming with the highest presence of total pesticide residues in different types of environmental waters. Risk quotient (RQ) acute and chronic was also evaluated in pond and river water as sometimes used for drinking purposes. RQ value (5900) of total endosulfan indicates the highest risk of chronic toxicity to river fishes. Seven water samples from tube-wells were also monitored and found to be contaminated with butachlor and chlorpyriphos in non-significant amounts (< 0.1 ng mL
−1
), irrespective of seasons and sites, thus safe for consumption.
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