Besonders erwähnt werden muß hierbei auch die Übersetzungsleistung von Peter Urban-Halle, der diese Mischung aus Andersenschen Tönen und de Mylius' kreativsuchenden Interpretationen sensibel, mit ...großer Präzision und dem Gefühl für sprachliche Feinheiten ins Deutsche übertragen hat. Teil drei erläutert anhand von Kierkegaards Kritik an der subjektiven Schreibweise Andersens (193 ff.) den Dichtertypus Andersen, "der in seinem Text nicht die Welt als solche spiegelt, sondern den Spiegel, der die Welt spiegelt" (194). Im Dualismus zwischen "Erfüllung" und "Entleerung" sieht de Mylius Andersens "extreme... und desperate...
Berättande bilder: svenska tecknade serier för barn/Helena Magnusson. Recensent: Nina Christensen New Voices in Children's Literature Criticism/Sebastian Chapleau (red) Recensent: Svenja Blume Modig ...och stark - eller ligga lågt. Skönlitteratur och genus i skola och förskola/Lena Kåreland (red) Recensent: Maria Simonsson
Texte remanié de: Magisterarbeit--Freiburg im Breisgau--Albert-Ludwigs-Universität, 1999.
Les citations sont en français, en suédois et en allemand. Notes bibliogr.
Das über Jahrhunderte hinweg tradierte Bild vom Norden, der Mythos vom Ursprünglichen, Natürlichen, von der Weite, Einsamkeit und Ruhe prägt entsprechend die mitteleuropäische Vorstellung von den ...Ländern am Polarkreis ebenso wie das Selbstbild der Skandinavier, die sich, bei allen innerskandinavischen Reibereien, gegenüber dem Kontinent gleichwohl als Einheit verstehen. Dieser Artikel befasst sich intensiv mit dem Heimatbild der Skandinavier, bzw. bezieht sich auf die Assoziationen von Heimat in Kinder- und Jugendliteratur über Skandinavien. (DIPF/Orig./J.K.).
Autosomal recessive congenital ichthyosis (ARCI) belongs to a heterogeneous group of disorders of keratinization. To date, 10 genes have been identified to be causative for ARCI. NIPAL4 (Nipa‐Like ...Domain‐Containing 4) is the second most commonly mutated gene in ARCI. In this study, we present a large cohort of 101 families affected with ARCI carrying mutations in NIPAL4. We identified 16 novel mutations and increase the total number of pathogenic mutations in NIPAL4 to 34. Ultrastructural analysis of biopsies from six patients showed morphological abnormalities consistent with an ARCI EM type III. One patient with a homozygous splice site mutation, which leads to a loss of NIPAL4 mRNA, showed additional ultrastructural aberrations together with a more severe clinical phenotype. Our study gives insights into the frequency of mutations, a potential hot spot for mutations, and genotype–phenotype correlations.
Reduction in beta-cell mass and function contributes to the pathogenesis of diabetes mellitus type 2. The proinflammatory cytokines tumor necrosis factor (TNF)α and interleukin (IL)-1β have been ...implicated in the pathogenesis of this disease. Overexpression of the dual leucine zipper kinase (DLK) inhibits beta-cell function and induces apoptosis in the beta-cell line HIT. In the present study, it was investigated whether TNFα or IL-1β stimulates DLK enzymatic activity. Immunoblot analysis, transient transfection with luciferase reporter gene assays, and immunofluorescence were used. In contrast to IL-1β, TNFα stimulated DLK kinase activity, which was dependent on the c-Jun N-terminal kinase (JNK). Furthermore, DLK contributed to TNFα-induced JNK phosphorylation. The phosphorylation of DLK on Ser-302 within the activation loop was required for DLK to stimulate JNK and to inhibit CREB-dependent gene transcription. TNFα induced apoptosis in a time- and concentration-dependent manner and inhibited CREB-directed gene transcription in HIT cells. The reduction of endogenous DLK by small interfering or small hairpin RNA attenuated TNFα’s effects on apoptosis and CREB-dependent transcription. These data suggest that TNFα induces beta-cell apoptosis through activation of DLK thereby inhibiting the beta-cell protective transcription factor CREB. Furthermore, activation of DLK by a well-known diabetic risk factor supports the role of DLK in the pathogenesis of diabetes mellitus. Thus, the inhibition of DLK might prevent or retard the pathogenesis of diabetes mellitus type 2.
A number of treatments targeting VEGF or mTOR pathways have been approved for metastatic clear cell Renal Cell Carcinoma (ccRCC), but the majority of patients show disease progression after first ...line therapy with a very low rate of complete or long-term responders. It has been shown that miRs may play a role in prediction of treatment response in various cancer types. The aim of our study was to identify a miR signature predictive for RCC patients' response to antiangiogenic tyrosine kinase inhibitor (TKI) treatment in the first line therapy. Sequencing of 40 paired normal/tumor formalin fixed and paraffin embedded ccRCC tissues revealed separate clustering via unsupervised dendrograms. With supervised analysis, the strongest differential expression was obtained with miR-99b-5p, which was significantly lower in patients with short progression free survival (<8 months) and TKI non-responders (progressive disease patients according to RECIST) (p<0.0001, each). Validation using RTqPCR and a second patient cohort compiled from three different hospitals (n=65) showed higher expression of miR-99b-5p in complete responders, but this trend did not reach statistical significance. It is concluded that low miR-99b-5p expression analyzed with sequencing methodology may correlate with tumor progression in TKI-treated ccRCC patients.
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