Organophosphate esters (OPEs) are synthetic chemicals found in many consumer products, including furniture, electronics, processed foods, and building materials. Emerging in vitro and in vivo studies ...suggest that OPEs are metabolism disrupting compounds; however, epidemiologic studies investigating their associations with adiposity markers are sparse.
We examined cross-sectional associations between OPE biomarkers and adiposity measures among U.S. children and adults participating in the National Health and Nutrition Examination Survey (NHANES: 2013–2014).
Concentrations of five OPE metabolites were quantified in urine: diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-chloroethyl) phosphate (BCEP), dibutyl phosphate (DBUP), and bis(1-chloro-2-propyl) phosphate (BCPP). We conducted covariate-adjusted logistic and linear regressions to examine associations between log2-transformed and dichotomized OPE metabolite concentrations and obesity, body mass index (BMI), and waist circumference (WC), separately among 784 children (6–19 years) and 1672 adults (≥20 years). We also assessed heterogeneity of associations by sex.
DBUP concentrations were inversely associated with the prevalence odds of being obese vs. normal weight in children (adjusted Prevalence Odds Ratio, aPOR: 0.82, 95% Confidence Interval, 95% CI: 0.70, 0.95) and adults (aPOR: 0.83, 95% CI: 0.72, 0.96). DBUP was also significantly associated with lower BMI z-scores (β:-0.08, 95% CI:-0.17, 0.01) and WC (β:-0.71, 95% CI: -1.49, 0.07) in children. BCEP concentrations were associated with increased prevalence odds of being overweight vs. normal weight (aPOR: 1.15, 95% CI: 1.01, 1.32) among children; similar, albeit not statistically significant, relationships were observed with other child adiposity outcomes. Among adults, detectable BCPP concentrations were associated with increased prevalence odds of being obese vs. normal weight (aPOR: 1.70, 95% CI: 1.21, 2.38) and having a high vs. normal WC (aPOR: 1.51, 95% CI: 1.11, 2.07) as well as higher BMI (β: 1.31, 95% CI: 0.30, 2.33). Other OPE metabolites were not consistently associated with adiposity measures among adults. Although associations of BCPP exposure with adiposity outcomes were generally inverse among boys, but not girls, we did not observe consistent evidence of sexually-dimorphic associations for other OPE metabolites.
Exposure to select OPEs may be differentially associated with body size among children and adults. Given the cross-sectional design of the present study, future prospective studies are needed to confirm these findings.
•DBUP was inversely associated with adiposity markers among children.•BCPP detection was positively associated with adiposity markers among adults.•Associations of BCPP with adiposity outcomes were generally inverse among boys.•Select OPEs may be differentially associated with body size in children and adults.
We report on the discovery and analysis of bursts from nine new repeating fast radio burst (FRB) sources found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. These ...sources span a dispersion measure (DM) range of 195-1380 pc cm−3. We detect two bursts from three of the new sources, three bursts from four of the new sources, four bursts from one new source, and five bursts from one new source. We determine sky coordinates of all sources with uncertainties of ∼10′. We detect Faraday rotation measures (RMs) for two sources, with values −20(1) and −499.8(7) rad m−2, that are substantially lower than the RM derived from bursts emitted by FRB 121102. We find that the DM distribution of our events, combined with the nine other repeaters discovered by CHIME/FRB, is indistinguishable from that of thus far non-repeating CHIME/FRB events. However, as previously reported, the burst widths appear statistically significantly larger than the thus far non-repeating CHIME/FRB events, further supporting the notion of inherently different emission mechanisms and/or local environments. These results are consistent with previous work, though are now derived from 18 repeating sources discovered by CHIME/FRB during its first year of operation. We identify candidate galaxies that may contain FRB 190303.J1353+48 (DM = 222.4 pc cm−3).
Rapid magnetic stimulation (RMS) of the phrenic nerves may serve to attenuate diaphragm atrophy during mechanical ventilation. With different coil shapes and stimulation location, inspiratory ...responses and side-effects may differ. This study aimed to compare the inspiratory and sensory responses of three different RMS-coils either used bilaterally on the neck or on the chest, and to determine if ventilation over 10 min can be achieved without muscle fatigue and coils overheating.
Healthy participants underwent bilateral anterior 1-s RMS on the neck (RMS
) (N = 14) with three different pairs of magnetic coils (parabolic, D-shape, butterfly) at 15, 20, 25 and 30 Hz stimulator-frequency and 20% stimulator-output with + 10% increments. The D-shape coil with individual optimal stimulation settings was then used to ventilate participants (N = 11) for up to 10 min. Anterior RMS on the chest (RMS
) (N = 8) was conducted on an optional visit. Airflow was assessed via pneumotach and transdiaphragmatic pressure via oesophageal and gastric balloon catheters. Perception of air hunger, pain, discomfort and paresthesia were measured with a numerical scale.
Inspiration was induced via RMS
in 86% of participants with all coils and via RMS
in only one participant with the parabolic coil. All coils produced similar inspiratory and sensory responses during RMS
with the butterfly coil needing higher stimulator-output, which resulted in significantly larger discomfort ratings at maximal inspiratory responses. Ten of 11 participants achieved 10 min of ventilation without decreases in minute ventilation (15.7 ± 4.6 L/min).
RMS
was more effective than RMS
and could temporarily ventilate humans seemingly without development of muscular fatigue. Trial registration This study was registered on clinicaltrials.gov (NCT04176744).
Abstract
We present the final catalogue of the 2dF QSO Redshift Survey (2QZ), based on Anglo-Australian Telescope 2dF spectroscopic observations of 44 576 colour-selected (ub
J
r) objects with 18.25 ...< b
J < 20.85 selected from automated plate measurement scans of UK Schmidt Telescope (UKST) photographic plates. The 2QZ comprises 23 338 quasi-stellar objects (QSOs), 12 292 galactic stars (including 2071 white dwarfs) and 4558 compact narrow emission-line galaxies. We obtained a reliable spectroscopic identification for 86 per cent of objects observed with 2dF. We also report on the 6dF QSO Redshift Survey (6QZ), based on UKST 6dF observations of 1564 brighter(16 < b
J < 18.25) sources selected from the same photographic input catalogue. In total, we identified 322 QSOs spectroscopically in the 6QZ. The completed 2QZ is, by more than a factor of 50, the largest homogeneous QSO catalogue ever constructed at these faint limits (b
J < 20.85) and high QSO surface densities (35 QSOs deg−2). As such, it represents an important resource in the study of the Universe at moderate-to-high redshifts. As an example of the results possible with the 2QZ, we also present our most recent analysis of the optical QSO luminosity function and its cosmological evolution with redshift. For a flat, Ωm= 0.3 and ΩΛ= 0.7, universe, we find that a double power law with luminosity evolution that is exponential in look-back time, τ, of the form L
*(z)∝ e6.15τ, equivalent to an e-folding time of 2 Gyr, provides an acceptable fit to the redshift dependence of the QSO LF over the range 0.4 < z < 2.1 and M
< −22.5. Evolution described by a quadratic in redshift is also an acceptable fit, with L
*(z)∝ 10.
We report on the discovery of eight repeating fast radio burst (FRB) sources found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. These sources span a dispersion measure ...(DM) range of 103.5-1281 pc cm−3. They display varying degrees of activity: six sources were detected twice, another three times, and one 10 times. These eight repeating FRBs likely represent the bright and/or high-rate end of a distribution of infrequently repeating sources. For all sources, we determine sky coordinates with uncertainties of ∼10′. FRB 180916.J0158+65 has a burst-averaged DM = 349.2 0.3 pc cm−3 and a low DM excess over the modeled Galactic maximum (as low as ∼20 pc cm−3); this source also has a Faraday rotation measure (RM) of −114.6 0.6 rad m−2, which is much lower than the RM measured for FRB 121102. FRB 181030.J1054+73 has the lowest DM for a repeater, 103.5 0.3 pc cm−3, with a DM excess of ∼70 pc cm−3. Both sources are interesting targets for multi-wavelength follow-up due to their apparent proximity. The DM distribution of our repeater sample is statistically indistinguishable from that of the first 12 CHIME/FRB sources that have not yet repeated. We find, with 4 significance, that repeater bursts are generally wider than those of CHIME/FRB bursts that have not repeated, suggesting different emission mechanisms. Many of our repeater events show complex morphologies that are reminiscent of the first two discovered repeating FRBs. The repetitive behavior of these sources will enable interferometric localizations and subsequent host galaxy identifications.
Abstract
The Canadian Hydrogen Intensity Mapping Experiment (CHIME) has become a leading facility for detecting fast radio bursts (FRBs) through the CHIME/FRB backend. CHIME/FRB searches for fast ...transients in polarization-summed intensity data streams that have 24 kHz spectral and 1 ms temporal resolution. The intensity beams are pointed to predetermined locations in the sky. A triggered baseband system records the coherent electric field measured by each antenna in the CHIME array at the time of FRB detections. Here we describe the analysis techniques and automated pipeline developed to process these full-array baseband data recordings. Whereas the real-time FRB detection pipeline has a localization limit of several arcminutes, offline analysis of baseband data yields source localizations with subarcminute precision, as characterized by using a sample of pulsars and one repeating FRB with known positions. The baseband pipeline also enables resolving temporal substructure on a microsecond scale and the study of polarization including detections of Faraday rotation.
A new approach in the treatment of cystic fibrosis involves improving the function of mutant cystic fibrosis transmembrane conductance regulator (CFTR). VX-770, a CFTR potentiator, has been shown to ...increase the activity of wild-type and defective cell-surface CFTR in vitro.
We randomly assigned 39 adults with cystic fibrosis and at least one G551D-CFTR allele to receive oral VX-770 every 12 hours at a dose of 25, 75, or 150 mg or placebo for 14 days (in part 1 of the study) or VX-770 every 12 hours at a dose of 150 or 250 mg or placebo for 28 days (in part 2 of the study).
At day 28, in the group of subjects who received 150 mg of VX-770, the median change in the nasal potential difference (in response to the administration of a chloride-free isoproterenol solution) from baseline was -3.5 mV (range, -8.3 to 0.5; P=0.02 for the within-subject comparison, P=0.13 vs. placebo), and the median change in the level of sweat chloride was -59.5 mmol per liter (range, -66.0 to -19.0; P=0.008 within-subject, P=0.02 vs. placebo). The median change from baseline in the percent of predicted forced expiratory volume in 1 second was 8.7% (range, 2.3 to 31.3; P=0.008 for the within-subject comparison, P=0.56 vs. placebo). None of the subjects withdrew from the study. Six severe adverse events occurred in two subjects (diffuse macular rash in one subject and five incidents of elevated blood and urine glucose levels in one subject with diabetes). All severe adverse events resolved without the discontinuation of VX-770.
This study to evaluate the safety and adverse-event profile of VX-770 showed that VX-770 was associated with within-subject improvements in CFTR and lung function. These findings provide support for further studies of pharmacologic potentiation of CFTR as a means to treat cystic fibrosis. (Funded by Vertex Pharmaceuticals and others; ClinicalTrials.gov number, NCT00457821.).
Abstract
We present a synthesis of fast radio burst (FRB) morphology (the change in flux as a function of time and frequency) as detected in the 400–800 MHz octave by the FRB project on the Canadian ...Hydrogen Intensity Mapping Experiment (CHIME/FRB), using events from the first CHIME/FRB catalog. The catalog consists of 62 bursts from 18 repeating sources, plus 474 one-off FRBs, detected between 2018 July 25 and 2019 July 2. We identify four observed archetypes of burst morphology (“simple broadband,” “simple narrowband,” “temporally complex,” and “downward drifting”) and describe relevant instrumental biases that are essential for interpreting the observed morphologies. Using the catalog properties of the FRBs, we confirm that bursts from repeating sources, on average, have larger widths, and we show, for the first time, that bursts from repeating sources, on average, are narrower in bandwidth. This difference could be due to beaming or propagation effects, or it could be intrinsic to the populations. We discuss potential implications of these morphological differences for using FRBs as astrophysical tools.
We report on the detection of seven bursts from the periodically active, repeating fast radio burst (FRB) source FRB 180916.J0158+65 in the 300-400 MHz frequency range with the Green Bank Telescope ...(GBT). Emission in multiple bursts is visible down to the bottom of the GBT band, suggesting that the cutoff frequency (if it exists) for FRB emission is lower than 300 MHz. Observations were conducted during predicted periods of activity of the source, and had simultaneous coverage with the Low Frequency Array (LOFAR) and the FRB backend on the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. We find that one of the GBT-detected bursts has potentially associated emission in the CHIME band (400-800 MHz) but we detect no bursts in the LOFAR band (110-190 MHz), placing a limit of on the spectral index of broadband emission from the source. We also find that emission from the source is severely band-limited with burst bandwidths as low as ∼40 MHz. In addition, we place the strictest constraint on observable scattering of the source, <1.7 ms at 350 MHz, suggesting that the circumburst environment does not have strong scattering properties. Additionally, knowing that the circumburst environment is optically thin to free-free absorption at 300 MHz, we find evidence against the association of a hyper-compact H ii region or a young supernova remnant (age <50 yr) with the source.
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