Abstract
To date, 241 individual molecular species, composed of 19 different elements, have been detected in the interstellar and circumstellar medium by astronomical observations. These molecules ...range in size from two atoms to 70 and have been detected across the electromagnetic spectrum from centimeter wavelengths to the ultraviolet. This census presents a summary of the first detection of each molecular species, including the observational facility, wavelength range, transitions, and enabling laboratory spectroscopic work, as well as listing tentative and disputed detections. Tables of molecules detected in interstellar ices, external galaxies, protoplanetary disks, and exoplanetary atmospheres are provided. A number of visual representations of these aggregate data are presented and briefly discussed in context.
To date, 204 individual molecular species, comprised of 16 different elements, have been detected in the interstellar and circumstellar medium by astronomical observations. These molecules range in ...size from 2 atoms to 70, and have been detected across the electromagnetic spectrum from centimeter wavelengths to the ultraviolet. This census presents a summary of the first detection of each molecular species, including the observational facility, wavelength range, transitions, and enabling laboratory spectroscopic work, as well as listing tentative and disputed detections. Tables of molecules detected in interstellar ices, external galaxies, protoplanetary disks, and exoplanetary atmospheres are provided. A number of visual representations of these aggregate data are presented and briefly discussed in context.
The fungal genus
Fusarium
is one of the most important groups of plant-pathogenic fungi and affects a huge diversity of crops in all climatic zones across the globe. In addition, it is also a human ...pathogen and produces several extremely important mycotoxins in food products that have deleterious effects on livestock and humans. These fungi have been plagued over the past century by different perspectives of what constitutes the genus
Fusarium
and how many species occur within the genus. Currently, there are conflicting views on the generic boundaries and what defines a species that impact disease diagnosis, management, and biosecurity legislation. An approach to defining and identifying
Fusarium
that places the needs of the community of users (especially, in this case, phytopathologists) to the forefront is presented in this review.
New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many ...different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven by soluble inflammatory mediators, which rely on JAK-STAT signaling, and inhibition of this pathway using JAK inhibitors might be a useful therapeutic strategy for these diseases. Growing evidence suggests that JAK inhibitors are efficacious in atopic dermatitis, alopecia areata, psoriasis, and vitiligo. Additional evidence suggests that JAK inhibition might be broadly useful in dermatology, with early reports of efficacy in several other conditions. JAK inhibitors can be administered orally or used topically and represent a promising new class of medications. The use of JAK inhibitors in dermatology is reviewed here.
The 17 Sustainable Development Goals (SDGs) and 169 targets under Agenda 2030 of the United Nations map a coherent global sustainability ambition at a level of detail general enough to garner ...consensus amongst nations. However, achieving the global agenda will depend heavily on successful national-scale implementation, which requires the development of effective science-driven targets tailored to specific national contexts and supported by strong national governance. Here we assess the feasibility of achieving multiple SDG targets at the national scale for the Australian land-sector. We scaled targets to three levels of ambition and two timeframes, then quantitatively explored the option space for target achievement under 648 plausible future environmental, socio-economic, technological and policy pathways using the Land-Use Trade-Offs (LUTO) integrated land systems model. We show that target achievement is very sensitive to global efforts to abate emissions, domestic land-use policy, productivity growth rate, and land-use change adoption behaviour and capacity constraints. Weaker target-setting ambition resulted in higher achievement but poorer sustainability outcomes. Accelerating land-use dynamics after 2030 changed the targets achieved by 2050, warranting a longer-term view and greater flexibility in sustainability implementation. Simultaneous achievement of multiple targets is rare owing to the complexity of sustainability target implementation and the pervasive trade-offs in resource-constrained land systems. Given that hard choices are needed, the land-sector must first address the essential food/fibre production, biodiversity and land degradation components of sustainability via specific policy pathways. It may also contribute to emissions abatement, water and energy targets by capitalizing on co-benefits. However, achieving targets relevant to the land-sector will also require substantial contributions from other sectors such as clean energy, food systems and water resource management. Nations require globally coordinated, national-scale, comprehensive, integrated, multi-sectoral analyses to support national target-setting that prioritizes efficient and effective sustainability interventions across societies, economies and environments.
Voltage-gated calcium channels are the primary mediators of depolarization-induced calcium entry into neurons. There is great diversity of calcium channel subtypes due to multiple genes that encode ...calcium channel α1 subunits, coassembly with a variety of ancillary calcium channel subunits, and alternative splicing. This allows these channels to fulfill highly specialized roles in specific neuronal subtypes and at particular subcellular loci. While calcium channels are of critical importance to brain function, their inappropriate expression or dysfunction gives rise to a variety of neurological disorders, including, pain, epilepsy, migraine, and ataxia. This Review discusses salient aspects of voltage-gated calcium channel function, physiology, and pathophysiology.
Urbanization and climate change are together exacerbating water scarcity-where water demand exceeds availability-for the world's cities. We quantify global urban water scarcity in 2016 and 2050 under ...four socioeconomic and climate change scenarios, and explored potential solutions. Here we show the global urban population facing water scarcity is projected to increase from 933 million (one third of global urban population) in 2016 to 1.693-2.373 billion people (one third to nearly half of global urban population) in 2050, with India projected to be most severely affected in terms of growth in water-scarce urban population (increase of 153-422 million people). The number of large cities exposed to water scarcity is projected to increase from 193 to 193-284, including 10-20 megacities. More than two thirds of water-scarce cities can relieve water scarcity by infrastructure investment, but the potentially significant environmental trade-offs associated with large-scale water scarcity solutions must be guarded against.
Electrochemical impedance spectroscopy is finding increasing use in electrochemical sensors and biosensors, both in their characterisation, including during successive phases of sensor construction, ...and in application as a quantitative determination technique. Much of the published work continues to make little use of all the information that can be furnished by full physical modelling and analysis of the impedance spectra, and thus does not throw more than a superficial light on the processes occurring. Analysis is often restricted to estimating values of charge transfer resistances without interpretation and ignoring other electrical equivalent circuit components. In this article, the important basics of electrochemical impedance for electrochemical sensors and biosensors are presented, focussing on the necessary electrical circuit elements. This is followed by examples of its use in characterisation and in electroanalytical applications, at the same time demonstrating how fuller use can be made of the information obtained from complete modelling and analysis of the data in the spectra, the values of the circuit components and their physical meaning. The future outlook for electrochemical impedance in the sensing field is discussed.
Conspectus The mismanagement and leakage of plastic waste into the environment are failures of modern society. Once in the environment, plastic waste degrades into microplastics on a time scale ...dependent on the resin chemistry and the associated biotic or abiotic process. The high surface area of microplastics results in the contamination of ecosystems through the leaching of toxic chemicals compounded with plastics during manufacturing. In addition, the small size of microplastics increases the likelihood that they will be inhaled or ingested, which has led to the bioaccumulation of microplastics with documented harm. Furthermore, microplastics are more readily aerosolized and distributed by weather systems to areas remote from locations where plastic waste has been mismanaged. Consequently, the carbon cycle must now account for plastic waste discharge, degradation, and dispersal in the environment after the end of useful life on a global scale. Circularity in plastics recycling endeavors to solve the waste problem while promoting greater sustainability. Circularity can be conducted at different stages in the plastics life cycle. Post-industrial recycling enabling scrap recovery in manufacturing is desirable for industrial material efficiency. However, the degradation of polymer chains currently limits the extent to which scrap recovery may be practiced repeatedly on the same material, particularly when the conversion of secondary resin to various plastic products is intolerant to deviations in polymer properties. Post-consumer recycling, on the other hand, is desirable for erasing the manufacturing history and use history of plastic-containing products. Post-consumer recycling involves cleaning and sorting plastic waste into bales, followed by mechanical recycling to produce dense feedstocks for downstream chemical processes required for deconstruction, monomer refinement, and secondary resin production. The efficiency and intensity of chemical processes used to recover reusable monomers or polymers remain low for most plastics. Consequently, there is an urgent need for novel polymers with useful or advantageous properties designed for recycling by addressing the challenges of resource recovery for reuse. In this Account, I discuss the design, discovery, and development of circular plastics based on the chemistry of polydiketoenamines. The diketoenamine bond provides a vantage point for the creation of thermoplastics, elastomers, and thermosets from polytopic triketone and amine monomers. The dynamic covalent character of the diketoenamine bond can be exploited during scrap recovery to provide resilience during mechanical recycling, maintaining baseline properties of the primary resin through multiple cycles of reuse. Furthermore, the hydrolyzability of the diketoenamine bond in strong acid can be exploited for efficient monomer recovery during chemical recycling. A systems-level analysis of polydiketoenamine circularity reveals substantive benefits in low-carbon manufacturing as well as a context to quantify the market potential, identifying use cases where circularity might be most effective. Leveraging these insights, it is possible to guide the process chemistry development necessary to scale monomer and resin production to meet imminent needs for more circular plastics in the market. These insights also provide a glimpse into the underlying molecular mechanisms critical to circularity in a new plastics economy while firmly establishing a role for creativity in polymer chemistry to provide innovative solutions.
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