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zadetkov: 501
1.
  • The endotoxin hypothesis of... The endotoxin hypothesis of neurodegeneration
    Brown, Guy C Journal of neuroinflammation, 09/2019, Letnik: 16, Številka: 1
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    The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting much of the outer ...
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2.
  • Neurophagy, the phagocytosi... Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease
    Vilalta, Anna; Brown, Guy C. The FEBS journal, October 2018, Letnik: 285, Številka: 19
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    It was previously thought that neurons were phagocytosed only when dead or dying. However, it is increasingly clear that viable synapses, dendrites, axons and whole neurons can be phagocytosed alive ...
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3.
  • Neuronal Loss after Stroke ... Neuronal Loss after Stroke Due to Microglial Phagocytosis of Stressed Neurons
    Brown, Guy C International journal of molecular sciences, 12/2021, Letnik: 22, Številka: 24
    Journal Article
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    After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and in ...
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4.
  • Living too long Living too long
    Brown, Guy C EMBO reports, 02/2015, Letnik: 16, Številka: 2
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    Longer lifespans, often ending with multiple diseases, threaten the viability of social and health systems. Rather than prolonging life further, research and funding should focus on increasing the ...
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5.
  • Neuronal Cell Death Neuronal Cell Death
    Fricker, Michael; Tolkovsky, Aviva M; Borutaite, Vilmante ... Physiological reviews, 04/2018, Letnik: 98, Številka: 2
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    Neuronal cell death occurs extensively during development and pathology, where it is especially important because of the limited capacity of adult neurons to proliferate or be replaced. The concept ...
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6.
  • How microglia kill neurons How microglia kill neurons
    Brown, Guy C; Vilalta, Anna Brain research, 12/2015, Letnik: 1628, Številka: Pt B
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    Abstract Microglia are resident brain macrophages that become inflammatory activated in most brain pathologies. Microglia normally protect neurons, but may accidentally kill neurons when attempting ...
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7.
  • Cell death by phagocytosis
    Brown, Guy C Nature reviews. Immunology, 02/2024, Letnik: 24, Številka: 2
    Journal Article
    Recenzirano

    Cells can die as a consequence of being phagocytosed by other cells - a form of cell death that has been called phagotrophy, cell cannibalism, programmed cell removal and primary phagocytosis. ...
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8.
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9.
  • Nitric oxide and neuronal d... Nitric oxide and neuronal death
    Brown, Guy C. Nitric oxide, 11/2010, Letnik: 23, Številka: 3
    Journal Article
    Recenzirano

    NO and its derivatives can have multiple effects, which impact on neuronal death in different ways. High levels of NO induces energy depletion-induced necrosis, due to: (i) rapid inhibition of ...
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  • Microglial phagocytosis of ... Microglial phagocytosis of live neurons
    Brown, Guy C; Neher, Jonas J Nature reviews. Neuroscience, 04/2014, Letnik: 15, Številka: 4
    Journal Article
    Recenzirano

    Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can ...
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zadetkov: 501

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