► Provides an overview of current state of catalyst support materials. ► Collates recent results on carbonaceous and non-carbonaceous catalyst supports. ► Critically analyses the improvements in ...catalyst–support interaction and stability.
Polymer electrolyte membrane fuel cells (PEMFC) and direct methanol fuel cells (DMFC) have found a wide variety of commercial applications. Their performance is essentially governed by the electrocatalyst support materials as they strongly influence the electrocatalyst performance, durability and efficiency. It is well known that carbonaceous support materials suffer from carbon corrosion (oxidation) especially at high potentials over time and thus alternative low-cost, high-performing and non-corrosive electrocatalyst support materials are urgently required. This review highlights the performance and issues associated with a variety of carbon based materials such as carbon nanotubes (CNT), carbon nanofibers (CNF), mesoporous carbon and graphene as well as non-carbonaceous based materials, e.g. titania, indium oxides, alumina, silica and tungsten oxide and carbide, ceria, zirconia nanostructures and conducting polymers catalyst support materials. Comparisons and advantages and disadvantages of the various supports are clearly described in this review.
Endpoints of active periodontal therapy Loos, Bruno G.; Needleman, Ian
Journal of clinical periodontology,
July 2020, 2020-07-00, 20200701, Letnik:
47, Številka:
S22
Journal Article
Recenzirano
Odprti dostop
Aim
Position paper on endpoints of active periodontal therapy for designing treatment guidelines. The question was as follows: How are, for an individual patient, commonly applied periodontal probing ...measures—recorded after active periodontal therapy—related to (a) stability of clinical attachment level, (b) tooth survival, (c) need for re‐treatment or (d) oral health‐related quality of life.
Methods
A literature search was conducted in Ovid MEDLINE(R) and Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations and Daily <1946 to 07 June 2019>.
Results
A total of 94 papers were retrieved. From the literature search, it was found that periodontitis patients with a low proportion of deep residual pockets after active periodontal therapy are more likely to have stability of clinical attachment level over a follow‐up time of ≥1 year. Other supporting literature confirms this finding and additionally reports, at the patient level, that probing pocket depths ≥6 mm and bleeding on probing scores ≥30% are risks for tooth loss. There is lack of evidence that periodontal probing measures after completion of active periodontal treatment are tangible to the patient.
Conclusions
Based on literature and biological plausibility, it is reasonable to state that periodontitis patients with a low proportion of residual periodontal pockets and little inflammation are more likely to have stability of clinical attachment levels and less tooth loss over time. Guidelines for periodontal therapy should take into consideration (a) long‐term tangible patient outcomes, (b) that shallow pockets (≤4 mm) without bleeding on probing in patients with <30% bleeding sites are the best guarantee for the patient for stability of his/her periodontal attachment, (c) patient heterogeneity and patient changes in immune response over time, and (d) that treatment strategies include lifestyle changes of the patient. Long‐term large population‐based and practice‐based studies on the efficacy of periodontal therapies including both clinical and patient‐reported outcomes (PROs) need to be initiated, which include the understanding that periodontitis is a complex disease with variation of inflammatory responses due to environment, (epi)genetics, lifestyle and ageing. Involving people living with periodontitis as co‐researchers in the design of these studies would also help to improve their relevance.
Periodontitis is a complex disease: (a) various causative factors play a role simultaneously and interact with each other; and (b) the disease is episodic in nature, and bursts of disease activity ...can be recognized, ie, the disease develops and cycles in a nonlinear fashion. We recognize that various causative factors determine the immune blueprint and, consequently, the immune fitness of a subject. Normally, the host lives in a state of homeostasis or symbiosis with the oral microbiome; however, disturbances in homeostatic balance can occur, because of an aberrant host response (inherited and/or acquired during life). This imbalance results from hyper‐ or hyporesponsiveness and/or lack of sufficient resolution of inflammation, which in turn is responsible for much of the disease destruction seen in periodontitis. The control of this destruction by anti‐inflammatory processes and proresolution processes limits the destruction to the tissues surrounding the teeth. The local inflammatory processes can also become systemic, which in turn affect organs such as the heart. Gingival inflammation also elicits changes in the ecology of the subgingival environment providing optimal conditions for the outgrowth of gram‐negative, anaerobic species, which become pathobionts and can propagate periodontal inflammation and can further negatively impact immune fitness. The factors that determine immune fitness are often the same factors that determine the response to the resident biofilm, and are clustered as follows: (a) genetic and epigenetic factors; (b) lifestyle factors, such as smoking, diet, and psychosocial conditions; (c) comorbidities, such as diabetes; and (d) local and dental factors, as well as randomly determined factors (stochasticity). Of critical importance are the pathobionts in a dysbiotic biofilm that drive the viscious cycle. Focusing on genetic factors, currently variants in at least 65 genes have been suggested as being associated with periodontitis based on genome‐wide association studies and candidate gene case control studies. These studies have found pleiotropy between periodontitis and cardiovascular diseases. Most of these studies point to potential pathways in the pathogenesis of periodontal disease. Also, most contribute to a small portion of the total risk profile of periodontitis, often limited to specific racial and ethnic groups. To date, 4 genetic loci are shared between atherosclerotic cardiovascular diseases and periodontitis, ie, CDKN2B‐AS1(ANRIL), a conserved noncoding element within CAMTA1 upstream of VAMP3, PLG, and a haplotype block at the VAMP8 locus. The shared genes suggest that periodontitis is not causally related to atherosclerotic diseases, but rather both conditions are sequelae of similar (the same?) aberrant inflammatory pathways. In addition to variations in genomic sequences, epigenetic modifications of DNA can affect the genetic blueprint of the host responses. This emerging field will yield new valuable information about susceptibility to periodontitis and subsequent persisting inflammatory reactions in periodontitis. Further studies are required to verify and expand our knowledge base before final cause and effect conclusions about the role of inflammation and genetic factors in periodontitis can be made.
The induction of antigen‐specific adaptive immunity exclusively occurs in lymphoid organs. As a consequence, the efficacy by which vaccines reach these tissues strongly affects the efficacy of the ...vaccine. Here, we report the design of polymer hydrogel nanoparticles that efficiently target multiple immune cell subsets in the draining lymph nodes. Nanoparticles are fabricated by infiltrating mesoporous silica particles (ca. 200 nm) with poly(methacrylic acid) followed by disulfide‐based crosslinking and template removal. PEGylation of these nanoparticles does not affect their cellular association in vitro, but dramatically improves their lymphatic drainage in vivo. The functional relevance of these observations is further illustrated by the increased priming of antigen‐specific T cells. Our findings highlight the potential of engineered hydrogel nanoparticles for the lymphatic delivery of antigens and immune‐modulating compounds.
Lymphatic transportation: PEGylation is shown to be a key parameter for lymphatic transportation of hydrogel nanoparticles. The PEGylated nanoparticles result in a high association with dendritic cells and B cells as well as increased T cell responses in vivo, which can be potentially used to improve the delivery of vaccines and drugs to the lymph nodes.
•Unconscious processing occurs at various levels of the visual system.•Different experimental methods tap into different unconscious levels.•Types and levels of unconscious vision depend on ...informational criterion content.•Search for neural correlates of consciousness requires knowing unconscious levels.
Numerous non-invasive experimental “blinding” methods exist for suppressing the phenomenal awareness of visual stimuli. Not all of these suppressive methods occur at, and thus index, the same level of unconscious visual processing. This suggests that a functional hierarchy of unconscious visual processing can in principle be established. The empirical results of extant studies that have used a number of different methods and additional reasonable theoretical considerations suggest the following tentative hierarchy. At the highest levels in this hierarchy is unconscious processing indexed by object-substitution masking. The functional levels indexed by crowding, the attentional blink (and other attentional blinding methods), backward pattern masking, metacontrast masking, continuous flash suppression, sandwich masking, and single-flash interocular suppression, fall at progressively lower levels, while unconscious processing at the lowest levels is indexed by eye-based binocular-rivalry suppression. Although unconscious processing levels indexed by additional blinding methods is yet to be determined, a tentative placement at lower levels in the hierarchy is also given for unconscious processing indexed by Troxler fading and adaptation-induced blindness, and at higher levels in the hierarchy indexed by attentional blinding effects in addition to the level indexed by the attentional blink. The full mapping of levels in the functional hierarchy onto cortical activation sites and levels is yet to be determined. The existence of such a hierarchy bears importantly on the search for, and the distinctions between, neural correlates of conscious and unconscious vision.
Decarbonising transport is proving to be one of today's major challenges for the global automotive industry due to many factors such as the increase in greenhouse gas and particulate emissions ...affecting not only the climate but also humans, the increase in pollution, rapid oil depletion, issues with energy security and dependency from foreign sources and population growth. For more than a century, our society has been dependent upon oil, and major breakthroughs in low- and ultra-low carbon technologies and vehicles are urgently required. This review paper highlights the current status of hybrid, battery and fuel cell electric vehicles from an electrochemical and market point of view. The review paper also discusses the advantages and disadvantages of using each technology in the automotive industry and the impact of these technologies on consumers.
Replacing fossil fuels with energy sources and carriers that are sustainable, environmentally benign, and affordable is amongst the most pressing challenges for future socio-economic development. To ...that goal, hydrogen is presumed to be the most promising energy carrier. Electrocatalytic water splitting, if driven by green electricity, would provide hydrogen with minimal CO
footprint. The viability of water electrolysis still hinges on the availability of durable earth-abundant electrocatalyst materials and the overall process efficiency. This review spans from the fundamentals of electrocatalytically initiated water splitting to the very latest scientific findings from university and institutional research, also covering specifications and special features of the current industrial processes and those processes currently being tested in large-scale applications. Recently developed strategies are described for the optimisation and discovery of active and durable materials for electrodes that ever-increasingly harness first-principles calculations and machine learning. In addition, a technoeconomic analysis of water electrolysis is included that allows an assessment of the extent to which a large-scale implementation of water splitting can help to combat climate change. This review article is intended to cross-pollinate and strengthen efforts from fundamental understanding to technical implementation and to improve the 'junctions' between the field's physical chemists, materials scientists and engineers, as well as stimulate much-needed exchange among these groups on challenges encountered in the different domains.
Most of the observations seen in the application of power ultrasound in electrochemistry or also known as sonoelectrochemistry are due to enhanced mass-transport of electroactive species from the ...bulk solution to the electrode surface caused by efficient stirring, acoustic streaming and cavitation. However, fundamental studies on the effect of ultrasound on electrode kinetics i.e. on the electron-transfer are scarce. The main question still remains to be answered:
Does power ultrasound affect heterogeneous electron transfer kinetics?
This opinion paper discusses the effect of ultrasonic frequency and intensity upon the electrode kinetic parameters such as the half-wave potential (E1/2) and the apparent heterogeneous rate constant (ko). A few sonoelectrochemical studies have highlighted changes in half-wave potential and in apparent heterogeneous rate constant for both quasi-reversible and irreversible systems when the data were compared to silent conditions. These observations are thought to be due to the contribution of mass-transport and macroscopic temperature effects, as well as the continuous cleaning of the electrode surface caused by the collapse of high-energy cavitation bubbles and the production of high velocity jets of liquid. However, there still remains mechanistic controversy in assigning whether these findings could also be due to localised temperature increases, the contribution of sonolysis products or solely due to enhanced mass-transport at the electrode surface. Thus, the effect of stirring, macroscopic temperature and sonication time upon these electrode kinetic parameters is also shown to be important factors in comparing the validity of any sonoelectrochemical effects.
Traditional risk factors for obesity and the metabolic syndrome, such as excess energy intake and lack of physical activity, cannot fully explain the high prevalence of these conditions. Insufficient ...sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight gain and have received increased research attention in the past 10 years. Insufficient sleep is defined as sleeping less than recommended for health benefits, whereas circadian misalignment is defined as wakefulness and food intake occurring when the internal circadian system is promoting sleep. This Review discusses the impact of insufficient sleep and circadian misalignment in humans on appetite hormones (focusing on ghrelin, leptin and peptide-YY), energy expenditure, food intake and choice, and risk of obesity. Some potential strategies to reduce the adverse effects of sleep disruption on metabolic health are provided and future research priorities are highlighted. Millions of individuals worldwide do not obtain sufficient sleep for healthy metabolic functions. Furthermore, modern working patterns, lifestyles and technologies are often not conducive to adequate sleep at times when the internal physiological clock is promoting it (for example, late-night screen time, shift work and nocturnal social activities). Efforts are needed to highlight the importance of optimal sleep and circadian health in the maintenance of metabolic health and body weight regulation.
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