► MFC utilizes DOMs in lake water for electricity generation. ► Protein-like substances were substantially degraded by MFC treatment. ► Genotoxic agents in polluted lake water were almost completely ...removed. ► A potential pretreatment technology for sustainable remediation of lake water.
A microbial fuel cell (MFC) was explored as a pretreatment method to remove dissolved organic matter (DOM) from polluted lake water and simultaneously generate electricity. After the MFC treatment, the total organic carbon concentration in the raw lake water was reduced by 50%, the physicochemical nature of DOMs was substantially altered. Protein-like substances in lake water were utilized as a major substrate for the MFC, while humic-like substances were refractory to the biodegradation. A further investigation into the bovine serum albumin utilization in an MFC confirms that the electricity generation was closely associated with the removal of protein-like substrates. Toxicity assessment by Salmonella typhimurium Sal94 indicates that the genotoxic agents in the polluted lake water were almost completely removed after the MFC treatment. This approach of coupling microbially-catalyzed electricity generation with DOM removal may offer a potential avenue for energy-efficient bioremediation of lake water.
The multiple-input-multiple-output (MIMO) synthetic aperture radar (SAR) system with a linear antenna array can obtain 3D resolution. In practice, it suffers from both the translational motion errors ...and the rotational motion errors. Conventional single-channel motion compensation methods could be used to compensate the motion errors channel by channel. However, this method might not be accurate enough for all the channels. What is more, the single-channel compensation may break the coherence among channels, which would cause defocusing and false targets. In this paper, both the translational motion errors and the rotational motion errors are discussed, and a joint multichannel motion compensation method is proposed for MIMO SAR 3D imaging. It is demonstrated through simulations that the proposed method exceeds the conventional methods in accuracy. And the final MIMO SAR 3D imaging simulation confirms the validity of the proposed algorithm.
Type 2 ryanodine receptor (RyR2) is the major calcium release channel in cardiac muscle. Phosphorylation of RyR2 by cAMP-dependent protein kinase A and by calmodulin-dependent protein kinase II ...modulates channel activity. Hyperphosphorylation at a single amino acid residue, Ser-2808, has been proposed to directly disrupt the binding of a 12.6-kDa FK506-binding protein (FKBP12.6) to RyR2, causing a RyR2 malfunction that triggers cardiac arrhythmias in human heart failure. To determine the structural basis of the interaction between Ser-2808 and FKBP12.6, we have employed two independent approaches to map this phosphorylation site in RyR2 by three-dimensional cryo-electron microscopy. In one approach, we inserted a green fluorescent protein (GFP) after amino acid Tyr-2801, and mapped the GFP three-dimensional location in the RyR2 structure. In another approach, the binding site of monoclonal antibody 34C was mapped in the three-dimensional structure of skeletal muscle RyR1. The epitope of antibody 34C has been mapped to amino acid residues 2,756 through 2,803 of the RyR1 sequence, corresponding to residues 2,722 through 2,769 of the RyR2 sequence. These locations of GFP insertion and antibody binding are adjacent to one another in domain 6 of the cytoplasmic clamp region. Importantly, the three-dimensional location of the Ser-2808 phosphorylation site is 105-120Å distance from the FKBP12.6 binding site mapped previously, indicating that Ser-2808 is unlikely to be directly involved in the binding of FKBP12.6 to RyR2, as had been proposed previously.
Abstract
Prediction of El Niño–Southern Oscillation (ENSO) is hindered by a spring predictability barrier (SPB). In this paper, we investigate the effects of the Indian Ocean (IO) on the SPB. Using a ...seasonally varying extended IO–ENSO recharge oscillator model, we find that the SPB is much weakened when IO is coupled with ENSO. To gauge the relative role of the Indian Ocean dipole (IOD) and the Indian Ocean Basin (IOB) modes in weakening ENSO SPB, we develop an empirical dynamical model, the linear inverse model (LIM). By coupling/decoupling the IOB or IOD mode with ENSO, we show that the IOB significantly weakens eastern Pacific and central Pacific ENSO SPBs, while the IOD plays a weaker role. The evolution of the optimum initial structures also illustrates the importance of the IOB in ENSO SPB. Moreover, the IOB strongly influences the forecast skill of La Niña SPB rather than El Niño SPB. This point is also identified through six coupled models from the North American multimodel ensemble. It may be related to the role of the IO in the asymmetry in the duration of El Niño and La Niña. The IOB-induced easterly wind anomalies are conducive to the development of La Niña and thus the prediction of La Niña events, whereas these anomalous easterlies are less important during the development of El Niño and the related forecast of El Niño events.
Potential tumor chemotherapeutic agents and tumor radio-imaging agents of – Cu
2+–salicylidene–amino acid Schiff bases–Phen (Bipy) ternary complexes have been designed and synthesized, their ...antitumor activity and tumor imaging of
64Cu labeled ones have been tested in tumor-bearing mice.
Potential tumor chemotherapeutic agents and tumor radio-imaging agents of – Cu
2+–salicylidene–amino acid Schiff bases–Phen (Bipy) ternary complexes have been designed and synthesized, their antitumor activity and tumor imaging of
64Cu labeled ones have been tested in tumor-bearing mice.
Transformations of the four polymorphs and magnetic transition of BaRuO3 under high pressure have been studied using first-principles calculations. We search for the low-enthalpy structures by ...relaxing four initial structural configurations under high pressure. We find that BaRuO3 exhibits sequential structural changes from nine-layer rhombohedral (9R), four-layer hexagonal (4H), six-layer hexagonal (6H), and finally to cubic perovskite (3C) structure, consistent well with the experiments. The three hexagonal crystallographic forms (9R, 4H and 6H) of BaRuO3 show paramagnetic states, whereas 3C-BaRuO3 displays a ferromagnetic ground state. Along with the pressure increasing, the magnetic moment of Ru in the 3C-BaRuO3 first come through a discontinuous drop around the critical pressure 26aaGPa, then becomes smaller gradually until zero at 180aaGPa. According to the theory of Moruzzi, this magnetic-nonmagnetic transition belongs to the type-III transition. The calculated pressure dependence of the enthalpies (a) and the volumes (b) of BaRuO3, reveals the pressure-induced phase transformation of BaRuO3. Display Omitted
Objective
To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.
Methods
A prospective, multicenter and registry study was carried out in 2,558 ...patients at 7 representative clinical sub-centers during November 3, 2016 to February 17, 2019. A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors. Additionally, stroke recurrence was defined as a primary outcome indicator.
Results
A total of 327 (12.78 %) patients endured recurrence events, 1,681 (65.72%) were men, and the average age was 63.33 ± 9.45 years. Totally 1,741 (68.06%) patients suffered first-ever ischemic stroke, 1,772 (69.27%) patients reported to have hypertension, and 1,640 (64.11%) of them reported dyslipidemia, 1,595 (62.35%) patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Specifically, 1,271 (49.69%) patients were considered as qi-deficient constitution, and 1,227 (47.97%) patients were determined as stagnant blood constitution. There were 1,303 (50.94%) patients diagnosed as blood stasis syndrome, 1,280 (50.04%) patients exhibited phlegm and dampness syndrome and 1,012 (39.56%) patients demonstrated qi deficiency syndrome. And 1,033 (40.38%) patients declared intracranial artery stenosis, and 478 (18.69%) patients reported carotid artery stenosis. The plaque in 1,508 (41.36%) patients were of mixed. Particularly, 41.09% of them demonstrated abnormal levels of glycated hemoglobin levels.
Conclusions
Recurrence in minor and small-artery stroke cannot be ignored. Hypertension, dyslipidemia, abnormal HbA1c, intracranial artery stenosis and carotid plaque were more common in stroke patients. Particularly, phlegm-dampness and blood stasis syndromes, as well as qi deficiency and blood stasis constitutions, were still the main manifestations of stroke. (Trial registration at ClinicalTrials.gov No. NCT03174535)
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