Neutrinoless double beta decay (0v\b{eta}\b{eta}) is considered the best potential resource to access the absolute neutrino mass scale. Moreover, if observed, it will signal that neutrinos are their ...own anti-particles (Majorana particles). Presently, this physics case is one of the most important research "beyond Standard Model" and might guide the way towards a Grand Unified Theory of fundamental interactions. Since the 0v\b{eta}\b{eta} decay process involves nuclei, its analysis necessarily implies nuclear structure issues. In the NURE project, supported by a Starting Grant of the European Research Council (ERC), nuclear reactions of double charge-exchange (DCE) are used as a tool to extract information on the 0v\b{eta}\b{eta} Nuclear Matrix Elements. In DCE reactions and \b{eta}\b{eta} decay indeed the initial and final nuclear states are the same and the transition operators have similar structure. Thus the measurement of the DCE absolute cross-sections can give crucial information on \b{eta}\b{eta} matrix elements. In a wider view, the NUMEN international collaboration plans a major upgrade of the INFN-LNS facilities in the next years in order to increase the experimental production of nuclei of at least two orders of magnitude, thus making feasible a systematic study of all the cases of interest as candidates for 0v\b{eta}\b{eta}.
Twenty patients affected by fever of unknown origin (FUO), due to a likely infection of the muscular or skeletal tissues, were studied by a Total Body scan with a monoclonal antibody fragment ...(Leukoscan) labelled with Tc-99m. The diagnostic procedure helped reach a final diagnosis in 8 out of the 20 patients because it identified the focus of the infection of the muscles or bones in joint proximity. Our data show that Leukoscan deserves to become a first line diagnostic procedure in the diagnostic algorithm for the evaluation of patients with FUO.
The article describes the main achievements of the NUMEN project together with an updated and detailed overview of the related R&D activities and theoretical developments. NUMEN proposes an ...innovative technique to access the nuclear matrix elements entering the expression of the lifetime of the double beta decay by cross section measurements of heavy-ion induced Double Charge Exchange (DCE) reactions. Despite the two processes, namely neutrinoless double beta decay and DCE reactions, are triggered by the weak and strong interaction respectively, important analogies are suggested. The basic point is the coincidence of the initial and final state many-body wave-functions in the two types of processes and the formal similarity of the transition operators. First experimental results obtained at the INFN-LNS laboratory for the 40Ca(18O,18Ne)40Ar reaction at 270 MeV, give encouraging indication on the capability of the proposed technique to access relevant quantitative information. The two major aspects for this project are the K800 Superconducting Cyclotron and MAGNEX spectrometer. The former is used for the acceleration of the required high resolution and low emittance heavy ion beams and the latter is the large acceptance magnetic spectrometer for the detection of the ejectiles. The use of the high-order trajectory reconstruction technique, implemented in MAGNEX, allows to reach the experimental resolution and sensitivity required for the accurate measurement of the DCE cross sections at forward angles. However, the tiny values of such cross sections and the resolution requirements demand beam intensities much larger than manageable with the present facility. The on-going upgrade of the INFN-LNS facilities in this perspective is part of the NUMEN project and will be discussed in the article.
These studies were conducted on 38 female patients treated with alendronate (10 mg/day, per os) for 3 years, because of osteoporosis. Of these patients, 29 were in the menopausal age longer than 10 ...years, and the remaining nine patients were in menopausa shorter than 10 years. Urine sample were taken at the start of the treatment and every 6 months afterward for 3 years, and crosslinked N-telopeptides of type I collagen (NTx) have been measured in them by means of an ELISA technique. Bone mineral density (BMD) has been recorded at the ultradistal (UDBMD) and mediodistal (MDBMD) region of radius of the non-dominant side. Body mass index (BMI) of the subjects has also been determined each time. The baseline values of NTx varied very much, scattered in a range of 11–215 nanomoles bone collagen equivalent/millimoles creatinine (nM BCE/mM Cr), in average 59±46; those of UDBMD and MDBMD amounted to 258±63 and 587±112 mg/cm
2, respectively. NTx, the BMD values and the menopausal age does not correlate with cach other. Both BMD values increased almost linearly in the total study pool during the 3-years-long treatment, being 3.0–9.2 and 0.8–2.5% higher in terms of UDBMD and MDBMD, respectively. Urine NTx concentrations decreased during the same time 30–35%. It is concluded that monitoring of urine NTx levels may be very useful during antiosteoporotic treatments, because a reduction of NTx is an indicator of the slowing down of bone turnover and the bone losses, as was observed during the alendronate therapy.
A new approach to search for CP violation in the neutrino sector 1,2 is proposed by the experiment called DAE{\delta}ALUS (Decay At rest Experiment for {\delta}cp At Laboratory for Underground ...Science). DAE{\delta}ALUS needs three sources of neutrino fluxes, each one located at 1.5, 8 and 20 km from the underground detector. Here we present the study for a Superconducting Ring Cyclotron able to accelerate the H2+ molecules and to deliver proton beam with maximum energy of 800 MeV and the required high power. The magnetic field produced by the proposed superconducting magnetic sector, simulated by the code TOSCA, the isochronous magnetic field, some preliminary feature on the beam dynamic and the magnetic forces acting on the coils are here presented.
A Multi Megawatt Cyclotron complex able to accelerate H2+ to 800 MeV/amu is under study. It consists of an injector cyclotron able to accelerate the injected beam up to 50 MeV/n and of a booster ring ...made of 8 magnetic sectors and 8 RF cavities. The magnetic field and the forces on the superconducting coils are evaluated using the 3-D code OPERA. The injection and extraction trajectories are evaluated using the well tested codes developed by the MSU group in the '80s. The advantages to accelerate H2+ are described and preliminary evaluations on the feasibility and expected problems to build the injector cyclotron and the ring booster are here presented.
These studies were conducted on 38 female patients treated with alendronate (10 mg/day, per os) for 3 years, because of osteoporosis. Of these patients, 29 were in the menopausal age longer than 10 ...years, and the remaining nine patients were in menopausa shorter than 10 years. Urine sample were taken at the start of the treatment and every 6 months afterward for 3 years, and crosslinked N-telopeptides of type I collagen (NTx) have been measured in them by means of an ELISA technique. Bone mineral density (BMD) has been recorded at the ultradistal (UDBMD) and mediodistal (MDBMD) region of radius of the non-dominant side. Body mass index (BMI) of the subjects has also been determined each time. The baseline values of NTx varied very much, scattered in a range of 11-215 nanomoles bone collagen equivalent/millimoles creatinine (nM BCE/mM Cr), in average 59+/-46; those of UDBMD and MDBMD amounted to 258+/-63 and 587+/-112 mg/cm(2), respectively. NTx, the BMD values and the menopausal age does not correlate with cach other. Both BMD values increased almost linearly in the total study pool during the 3-years-long treatment, being 3.0-9.2 and 0.8-2.5% higher in terms of UDBMD and MDBMD, respectively. Urine NTx concentrations decreased during the same time 30-35%. It is concluded that monitoring of urine NTx levels may be very useful during antiosteoporotic treatments, because a reduction of NTx is an indicator of the slowing down of bone turnover and the bone losses, as was observed during the alendronate therapy.
This conceptual design report describes the technical facility for the IsoDAR electron-antineutrino source at KamLAND. The IsoDAR source will allow an impressive program of neutrino oscillation and ...electroweak physics to be performed at KamLAND. This report provides information on the physics case, the conceptual design for the subsystems, alternative designs considered, specifics of installation at KamLAND, and identified needs for future development. We discuss the risks we have identified and our approach to mitigating those risks with this design. A substantial portion of the conceptual design is based on three years of experimental efforts and on industry experience. This report also includes information on the conventional facilities.
This paper introduces a novel, high-intensity source of electron antineutrinos from the production and subsequent decay of 8Li. When paired with an existing ~1 kton scintillator-based detector, this ...<E_\nu>=6.4 MeV source opens a wide range of possible searches for beyond standard model physics via studies of the inverse beta decay interaction. In particular, the experimental design described here has unprecedented sensitivity to electron antineutrino disappearance at \(\Delta m^2\sim\) 1 eV\(^2\) and features the ability to distinguish between the existence of zero, one, and two sterile neutrinos.
This whitepaper reviews design options for the IsoDAR electron antineutrino source. IsoDAR is designed to produce \(2.6 \times 10^{22}\) electron antineutrinos per year with an average energy of 6.4 ...MeV, using isotope decay-at-rest. Aspects which must be balanced for cost-effectiveness include: overall cost; rate and energy distribution of the electron antineutrino flux and backgrounds; low technical risk; compactness; simplicity of underground construction and operation; reliability; value to future neutrino physics programs; and value to industry. We show that the baseline design outlined here is the most cost effective.
