•We present quasi-geostrophic eigenmodes for cores of terrestrial-type planets.•Dependence of mode properties on Lehnert and Lundquist numbers is documented.•Magnetic diffusion causes slow modes to ...rapidly decay, especially in Mercury’s core.•Fast modes will play important roles in the cores of Earth, Ganymede and Mercury.
The core of a terrestrial-type planet consists of a spherical shell of rapidly rotating, electrically conducting, fluid. Such a body supports two distinct classes of quasi-geostrophic (QG) eigenmodes: fast, primarily hydrodynamic, inertial modes with period related to the rotation time scale and slow, primarily magnetic, magnetostrophic modes with much longer periods. Here, we investigate the properties of these hydromagnetic quasi-geostrophic modes as a function of non-dimensional parameters controlling the strength of the background magnetic field, the planetary rotation rate, and the amount of magnetic dissipation.
We first present analytic solutions that illustrate the essential parameter dependences of the modes and provide a convenient benchmark for our numerical scheme. A comparison between known three-dimensional inertial modes in a sphere and our axially invariant QG modes shows encouraging agreement at low azimuthal wavenumbers, particularly for the slowest modes. The container geometry and background magnetic field structure are found to influence the radial structure of the modes, but not the scaling of their frequency with the control parameters. When the background magnetic field decreases toward the outer boundary in a spherical shell, QG modes tend to be compressed towards the outer boundary. Including magnetic dissipation, we find a continuous transition from diffusionless slow magnetic modes into quasi-free decay magnetic modes. During that transition (which is controlled by the magnitude of the Elsasser number), we find that slow magnetic modes weakly modified by diffusion exhibit a distinctive spiralling planform. When magnetic diffusion is significant (Elsasser number much smaller than unity), we find quasi-free decay slow magnetic modes whose decay time scale is comparable to, or shorter than, their oscillation time scale.
Based on our analysis, we expect Mercury to be in a regime where the slow magnetic modes are of quasi-free decay type. Earth and possibly Ganymede, with their larger Elsasser numbers, may possess slow modes that are in the transition regime of weak diffusion, depending on the details of their poorly known internal magnetic fields. Fast QG modes, that are almost unaffected by the background magnetic field, are expected in the cores of all three bodies.
The Campero-INTA chicken of Argentina was developed to provide a robust bird that can survive under Argentinian pasture conditions with no significant additional nutrition, producing a source of ...animal protein for small producers or low-income families. In previous work, we described the AH paternal line of Campero and its Major Histocompatibility Complex B region (MHC-B) variation. In this work we analyzed the three remaining synthetic lines used to produce the Campero-INTA production bird: lines AS, A, and E. Because of the association between variation within the MHC of chickens and disease resistance, MHC variation within this breed is of particular interest. MHC variability within the lines used to produce the Campero-INTA chicken was examined using a 90 SNP panel encompassing the chicken MHC-B region plus the VNTR, LEI0258, located within the chicken MHC. Across all 4lines 12 haplotypes were found, with 7 of these being previously reported in North America/European breeds, reflecting the original breed sources for these birds. Three Campero unique haplotypes were found, 2 of which likely originated from MHC recombination events. MHC-B variation for all lines involved with production of the final Campero-INTA bird has now been determined.
Psychological impact of Medical Evacuation (MEDEVAC) in Covid-19 patients is undetermined. The objectives were to evaluate: Post-traumatic Stress Disorder (PTSD) in MEDEVAC patients hospitalized in ...ICU for Covid-19-related acute respiratory distress syndrome (ARDS) compared to control group; anxiety, depression rates and outcomes in patients and PTSD in relatives.
This is a retrospective multicentric 1/1 paired cohort performed in 10 ICUs in the West of France. Evaluation was performed 18 months after discharge. Patients and closest relatives performed IES-R (Impact and Event Scale-Revised) and/or HADS (Hospital Anxiety and Depression Scale) scales.
Twenty-six patients were included in each group. Patients were 64 ± 11 years old, with 83% male. We report 12 vs 20% of PTSD in control vs MEDEVAC groups (p = 0.7). Anxiety disorder affected 43.5 vs 28.0% (p = 0.26) and depression 12.5 vs 14.3% (p > 0.99) in control vs MEDEVAC groups. PTSD affects 33.3 vs 42.1% of closest relatives (p = 0.55). Ways of communication were adapted: video calls were more frequent in MEDEVAC patients (8.7 vs 60.9%, p < 0.01) whereas physical visits concerned more control group (45.8 vs 13.0%, p = 0.01).
PTSD rate were similar between groups. Adaptive ways of communication, restricted visits and global uncertainties could explain the absence of differences.
Summary
Background
Among patients with thrombotic microangiopathies, acute kidney injury (AKI) is the hallmark of hemolytic uremic syndrome (HUS) and is largely underestimated in patients with ...thrombotic thrombocytopenic purpura (TTP).
Objective
We sought to report AKI features and outcomes in patients with TTP.
Methods
We conducted a retrospective study of 92 patients with TTP assessed by low ADAMTS13 activity (< 10%) between 2001 and 2013. A logistic regression identified variables independently associated with AKI.
Results
Among the 92 patients, 54 (58.7%) presented with AKI, including 25 (46.3%) with stage 3 AKI. Fourteen (27.4%) patients had a nephrotic‐range proteinuria and 21 (45.6%) had hemoglobinuria. Hematuria and leucocyturia were detected in 19 (41.3%) and 16 patients (36.4%), respectively. Renal replacement therapy (RRT) was required in 14 patients (25.9%). Six months after TTP remission, RRT‐free patients had median (IQR) MDRD (Modification of Diet in Renal Disease formula estimating the glomerular filtration rate) of 93 mL min−1 per 1.73 m2 (68.8–110) and three patients required long‐term dialysis. Mild or moderate chronic renal disease occurred in 23/54 (42.6%) AKI patients. By multivariate analysis, serum level of complement component 3 at admission was the only factor independently associated with AKI (OR per 0.25 unit decrease of C3, 0.85; CI, 1.82–8.33; P = 0.001).
Conclusions
In patients with TTP, AKI is present in more than half the patients, and half of those will have lasting renal effects. Further studies to better understand the pathophysiology of renal involvement in patients with TTP and to identify a subset of patients with TTP syndrome overlapping HUS are warranted.
La producción de carne aviar en sistemas de manejo semi-intensivo es una modalidad ecológica que contempla aspectos vinculados con el bienestar animal. El pollo Campero es un ave con menor velocidad ...de crecimiento que los parrilleros comerciales, destinado a la producción de carne. El esquema tradicional de alimentación incluye la utilización de tres tipos de alimentos especialmente formulados a tal fin (iniciador, crecimiento y terminador), lo cual introduce complicaciones en el manejo, particularmente en lo referido a la disponibilidad del alimento “crecimiento” para los pequeños productores. Una alternativa que facilitaría el manejo de estas aves es un esquema basado en sólo dos tipos de alimentos: iniciador y terminador. El objetivo de este trabajo fue evaluar el efecto del cambio del manejo tradicional de la alimentación por uno alternativo reemplazando el alimento “crecimiento” por una mezcla de iniciador y terminador, en dos genotipos de pollo Campero con diferente velocidad de crecimiento: el híbrido experimental de tres vías Campero Casilda y el híbrido simple Campero INTA. La evidencia indicó que el cambio en el manejo de la alimentación no afectó el crecimiento, la relación de conversión ni los caracteres a la faena. Ambos grupos genéticos se comportaron de manera equivalente, pudiendo obviarse la inclusión de la categoría “crecimiento” si se la reemplaza por una mezcla de iniciador y terminador.
The use of steroids is not required in myeloid malignancies and remains controversial in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). We sought to evaluate ...dexamethasone in patients with ALI/ARDS caused by acute monocytic leukaemia (AML FAB-M5) via either leukostasis or leukaemic infiltration. Dexamethasone (10 mg every 6 h until neutropenia) was added to chemotherapy and intensive care unit (ICU) management in 20 consecutive patients between 2005 and 2008, whose data were compared with those from 20 historical controls (1994-2002). ICU mortality was the primary criterion. We also compared respiratory deterioration rates, need for ventilation and nosocomial infections. 17 (85%) patients had hyperleukocytosis, 19 (95%) had leukaemic masses, and all 20 had severe pancytopenia. All patients presented with respiratory symptoms and pulmonary infiltrates prior to AML FAB-M5 diagnosis. Compared with historical controls, dexamethasone-treated patients had a significantly lower ICU mortality rate (20% versus 50%; p = 0.04) and a trend for less respiratory deterioration (50% versus 80%; p = 0.07). There were no significant increases in the rates of infections with dexamethasone. In conclusion, in patients with ALI/ARDS related to AML FAB-M5, adding dexamethasone to conventional chemotherapy seemed effective and safe. These results warrant a controlled trial of dexamethasone versus placebo in AML FAB-M5 patients with noninfectious pulmonary infiltrates.
Patients with autoimmune hemolytic anemia (AIHA) may require intensive care unit (ICU) admission. In order to describe the characteristics of AIHA patients in ICU and identify prognosis factors, ...clinical and biological data from 44 patients admitted in one ICU between 2002 and 2015 were retrospectively analyzed. The main reasons for ICU admission were profound anemia without any organ failure in 19 patients (either for safer transfusion or continuous monitoring only). Twenty-five (57%) patients had a past history of hemopathy. Twenty patients presented with a direct anti-globulin test (DAT) positive for immunoglobulin G (DAT-IgG) only (46%), 8 with a DAT positive for both IgG and complement (DAT-IgG+C) (36%), and 16 with a DAT positive for complement only (DAT-IgG+C) (18%). Corticosteroids and rituximab were administered to respectively 44 (100%) and 12 (25%) patients. Red blood cell transfusion was required in 28 (64%) patients. Ten (23%) patients received vasopressors. Renal replacement therapy was necessary in 14 (31.8%) patients. Thirteen (30%) patients died in the ICU. There was no difference between survivors and non-survivors regarding associated comorbidities like hemopathy (18/31 58% vs. 7/13 54%,
p
= 0.80). In decedents, age was higher (72 years 57.8–76.3 vs. 50 years 34.3–64,
p
< 0.01) and organ dysfunctions were more severe at day 1 (SOFA 8 7–11 vs. 5.5 3–7,
p
< 0.01). Patients with a DAT-IgG displayed poorer outcome in comparison with patients with DAT-IgG+C/C (hospital mortality 69% vs. 36%,
p
= 0.04). Mortality rate of AIHA patients requiring ICU admission is consequential and appears to be impacted by age, organ failures, and DAT-IgG.
Hyperviscosity syndrome Dumas, G; Merceron, S; Zafrani, L ...
La revue de medecine interne
36, Številka:
9
Journal Article
Recenzirano
Odprti dostop
Hyperviscosity syndrome is a life-threatening complication. Clinical manifestations include neurological impairment, visual disturbance and bleeding. Measurement of plasma or serum viscosity by a ...viscometer assesses the diagnosis. Funduscopic examination is a key exam because abnormalities are well-correlated with abnormal plasma viscosity. Etiologies are various but symptomatic hyperviscosity is more common in Waldenström's macroglobulinemia and multiple myeloma. Prompt treatment is needed: treatment of the underlying disease should be considered, but generally not sufficient. Symptomatic measures aim to not exacerbate blood viscosity while urgent plasmapheresis effectively reduces the paraprotein concentration and relieves symptoms.
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