Eplingiella fruticosa (Lamiaceae), formally known as Hyptis fruticosa, is an important aromatic medicinal herb used in folk medicine in northeastern Brazil. We aimed to evaluate the anti-hyperalgesic ...effect of essential oil obtained from E. fruticosa (HypEO) complexed with βCD (HypEO-βCD) in a chronic widespread non-inflammatory muscle pain animal model (a mice fibromyalgia-like model, FM). The HypEO was extracted by hydro distillation and its chemical composition was determined by GC-MS/FID. Moreover, Fos protein expression in the spinal cord was assessed by immunofluorescence. (E)-caryophyllene, bicyclogermacrene, 1,8-cineole, α-pinene, β-pinene and 21 other compounds were identified in the HypEO. The treatment with HypEO-βCD produced a longer-lasting anti-hyperalgesic effect compared to HypEO, without alterations in motor coordination or myorelaxant effects. Moreover, HypEO and HypEO-βCD produced a significant anti-hyperalgesic effect over 7 consecutive treatment days. Immunofluorescence assay demonstrated a decrease in Fos protein expression in the spinal cord (p < 0.001). We demonstrated that the anti-hyperalgesic effect produced by HypEO was improved after complexation with β-CD and this seems to be related to the central pain-inhibitory pathway, suggesting the possible use of E. fruticosa for chronic pain management.
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•GC-MS/FID analysis identified twenty-six (26) compounds in E. fruticosa leaves.•HypEO-βCD and HypEO produced an anti-hyperalgesic profile on chronic pain.•Fos protein expression in the spinal cord also prove the mechanism of the EOs.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
No Modelo Padrão que descreve a física das partículas elementares e suas interações o campo de Higgs pode ser imaginado como um campo composto formado por uma força forte ainda desconhecida. Tal hípótese é bastante atrativa para completar o Modelo Padrão a altas energias. Problemas como hierarquia e naturalidade podem ser mais facilmente evitados. No contexto de uma força forte porém métodos de cálculo baseados em expansões perturbativas não tem mais validade. Uma alternativa para entender as propriedades básicas desse tipo de teoria é trabalhar em termos de teorias de gravitacão com dimensões extras. Nesta tese focamos no caso de uma dimensão espacial extra. Características genéricas desse tipo de cenário são a existência de partículas de gravidade massivas, associadas com a métrica penta-dimensional que acopla com o Modelo Padrão para matéria, levando a assinaturas diretas em colisores de partículas (como o LHC no CERN). Tais partículas de gravidade se acoplam com o setor de Higgs. A descoberta do bóson de higgs abriu um novo camp o de investigação para sua detecção direta, no estado final com dois bósons de higgs. Nós usamos técnicas de Monte Carlo para estudar as estratégias de análise que levariam a um melhor reconhecimento de novas ressonâncias que decaem em pares de bósons de higgs em colisores hadrônicos, que podem ser interpretadas como partículas de gravidade massivas. Finalmente apresentamos as buscas experimentais por tais ressonâncias realizadas no contexto do experimento CMS com dados retirados do primeiro run do LHC (com uma energia de centro de massa de 8 TeV)
The Higgs field of the Standard Model theory for elementary particles and interactions can be realized as a composite state from an underlying strong sector. Such hypothesis is very attractive as an ultraviolet completion of the Standard Model since it solves the hierarchy and avoids naturalness problems. The standard perturbative methods cannot be used in the context of strongly interacting theories, however thyose can be broadly describes in terms of extra dimensional models of gravity. We focus on the case of one additional Warped compact Extra Dimension (WED). The generic signatures of this scenario are the manifestation of heavy gravity particles, associated with the five dimensional metric, that couples with the Standard Model matter leading to direct collider signatures. The heavy gravity particles couples to the Higgs sector. The Higgs discovery had oponed a new investigation channel to LHC direct detection that is the di-higgs final state. We use Monte Carlo techniques to study the analysis strategies that would lead to a best recognition of new resonances decaying to a pair of higgses in hadron colliders, that can be interprets as the gravity particles. We finally present resonance searches performed with data taken by the CMS experiment on the 8 TeV LHC run. The results are interpreted as the gravity particles signatures in the WED context
CNPq: 141964/2009-0
Background and objectives: Modern society food habits have caused an increase in the incidence of non communicable chronic diseases (NCD). Although these food habits present diversity, they are ...mostly associated with obesiogenic metabolic disorders. Growing consumption of industrialized foods with high glycemic index and caloric density has increased the incidence of obesity-related diseases, commonly a result of metabolic disorders induced by diet. Thus, the objective of this study is to investigate the effect of diet on the parameters involved in the genesis of these complex sets of metabolic alterations. In this study an experimental diet was produced and analyzed, evaluating its effect on markers of metabolic disorders. Methods: Two groups of adult male Wistar rats (n = 5 for each group) were feed with a standard or experimental diet for 17 weeks. Centesimal composition, glycemic index and glycemic load were determined for the experimental diet. Animals were evaluated during the experiment using abdominal perimeter and Lee index. At the end of the experiment, biochemical metabolic analysis and PPARγ mRNA expression in retroperitoenal and gonadal adipose tissue were performed. Results: The experimental diet group presented a high glycemic index and glycemic load, increasing Lee index and abdominal perimeter of animals from the 6th week of experiment. Fasting glycaemia, triglycerides, VLDL-C, retroperitoenal and gonadal adipose tissue PPARγ expression were significantly increased in the experimental diet group in comparison to standard diet group (p < 0.05). Conclusions: Thus, the results indicate that this diet represents a new model to induce obesity and metabolic disorders and might contribute for further studies in the field.
A capacidade das Instituições de Ensino Superior (IES) adotarem políticas e dinâmicas promotoras de interculturalidade para a inclusão dos estudantes apresenta-se como um desafio face aos relatos de ...vivências de exclusão académica dos participantes deste estudo. Foi objetivo deste estudo compreender a experiência vivida pelos participantes, na academia, como fenómeno de inclusão/exclusão. Relativamente aos métodos, trata-se de um estudo qualitativo, fenomenológico-interpretativo, com recurso à entrevista fenomenológica. Participaram trinta e um elementos da comunidade académica (estudantes, docentes e não docentes) de uma IES de Portugal, de abril a julho de 2019. A análise dos dados emergentes foi qualitativa e realizada com ajuda do software Nvivo12. Este estudo insere-se num projeto mais amplo intitulado “Práticas inclusivas no Ensino Superior: O desafio de construir comunidade”, autorizado pela Comissão de Ética da Instituição onde se realizou o estudo. Quanto aos Resultados, das categorias emergentes destacamos a Experiência e significado de inclusão, com destaque para a “Indiscriminação”, “Igualdade e equidade” e “Integração na comunidade”; as Barreiras à inclusão na instituição, com ênfase nas “Barreiras Arquitetónicas”, na “Desarticulação hierárquica institucional, “dificuldades linguísticas” e, ainda, a categoria Sentimentos vivenciados em experiências de exclusão, enfatizados pelos participantes, como a “desvalorização”, a “solidão” e a “tristeza”. Em conclusão, os participantes consideram que os principais desafios institucionais à inclusão e interculturalidade se centram no derrubar as barreiras arquitetónicas e linguísticas, de forma a que os edifícios tenham acessos adequados à mobilidade, que garantam a sua integração e minimizem sentimentos de desvalorização, solidão e tristeza.
Family Health Strategies (ESFs) play an important role in nursing and aim to expand, define and consolidate primary health care. The nurse must integrate the FHS team and work continuously in the ...chronic disease control program. The objective of this study was to describe the role of nurses in the care of patients with diabetes and arterial hypertension in primary care. The method was a narrative review of the literature with an exploratory, observational and retrospective research approach, searching for 20 articles in the literature between 2010 and 2020. RESULTS: When evaluating the nursing effects cited by nurses, nursing was predominant in relation to food and humidity, followed by glycemic control, blood pressure and breastfeeding weight. On the other hand, the nursing process is a technology that can humanize care in a systematic and dynamic way, with positive and low-cost results. It was concluded that the role of the nurse as an educator is fundamental for both the patient and the family, and must follow their guidelines to understand and be aware of the importance of treatment and activities to improve quality of life.
The Family Health Strategy (ESF) has a fundamental role in care and aims to expand, define and consolidate primary health care. The nurse must be part of the ESF team and continuously work on the ...chronic disease control plan. The aim of this study is to describe the role of nurses in the care of patients with diabetes mellitus and hypertension in primary care. The methodology is a study of narrative literature review with an approach of exploratory, observational, retrospective studies that were searched in the literature 20 articles between 2010 and 2020. Results: In the assessment of the role of nursing cited by nurses' care, predominant nursing related to food and humidity, followed by glycemic control, blood pressure and nursing weight. On the other hand, the nursing process is a technology that allows humanized care in a systematic and dynamic way, with positive results and low cost. It is concluded that the role of the nurse as an educator is essential for both the patient and the family, and they must follow their guidelines in order to understand and realize the importance of the treatment and activities performed to improve the quality of life.
Objetivo: Analisar como a equipe de Enfermagem do Centro Cirúrgico de um hospital público vivencia a humanização no ambiente de trabalho.Método: Trata-se de pesquisa descritiva, transversal, ...exploratória com abordagem quantitativa, realizada no centro cirúrgico de um hospital público do Distrito Federal. Resultados: A amostra foi composta por cinqüenta e oito (58) profissionais entre Enfermeiros e Técnicos. Prevaleceu o sexo feminino 42 (72,4%), com predomínio de enfermeiros 30 (51,7%) trabalhando na unidade atual há mais de cinco anos 23 (39,7%). Ambiente de trabalho humanizado 39 (67,2%), com acolhimento ao usuário 49 (84,5%). Conclusão: Conclui-se que há carência de humanização voltada aos profissionais de enfermagem, expressou-se a necessidade de um ambiente mais favorável ao cuidado humanizado, facilitando suas atividades não apenas com perfil técnico e científico, mas também com um perfil mais caloroso, próximo do usuário e dos colegas de trabalho.
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