Pilomatrixoma of the eyelid Rosa, Nicola; Lanza, Michele; Cennamo, Gilda ...
Journal of Dermatological Case Reports,
07/2008, Letnik:
2, Številka:
2
Journal Article
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Pilomatrixoma is a benign tumor of the hair follicle that can transform into a malignant lesion, the pilomatrix carcinoma. We present an unusual case of an eyelid pilomatrixoma.
A 37-year-old white ...male presented with rapidly growing, pedunculated lesion located at the superior right eyelid of five months duration. The lesion was excised under local anaesthesia. The sample was fixed in 10% formalin and histopathological as well as immunohistochemical analyses were performed. Results of both examinations were consistent with a benign pilomatrixoma.
Even though the lesion had malignant clinical appearance, histopathology confirmed the diagnosis of a benign pilomatrixoma, supporting the decision not to make a more extensive surgery.
Antihistamines (histamine H(1) receptor antagonists) are effective and convenient drugs for the treatment of allergic conjunctivitis. Because of the short duration of action generally observed for ...drugs administered topically to the eye, the oral route is often preferred. However, the presence of a selective barrier between blood and ocular tissues, the so-called blood-ocular barrier, does not allow a priori assessment of the most suitable dosage for ocular therapy.
To investigate the tear concentrations of cetirizine, a second-generation antihistamine, over time following oral administration, and to study the relationship between plasma and tear fluid concentrations.
Pharmacokinetic study of a single oral dose of cetirizine 10mg in 40 patients treated for allergic conjunctivitis.
Patients received a single oral dose of cetirizine. Samples of blood and tear fluid were taken according to predefined sampling schedules and the concentrations of cetirizine were determined by a new high performance liquid chromatography method.
Concentration-time profiles for cetirizine in serum and tear fluid were similar, although the mean maximum concentration in tear fluid was reached later than in serum (90 and 30 min, respectively). However, at 60 and 120 min the cetirizine concentration in tear fluid was 98 and 92% of the mean maximum concentration, respectively, showing a plateau region and indicating that the disposition rate for the tear fluid compartment was very similar to that for the blood compartment.
Oral administration of cetirizine yields therapeutically effective concentrations of the drug at the anterior surface of the eye.
We have observed a male and a female, sibs of non-consanguineous parents, affected by severe myopia with characteristic retinal defects and Dandy-Walker variant. The peculiarity of the retinopathy ...consists of pathological myopia with anomalous vitreal fenestrated membranes in the retinal periphery. We suppose that these associations may configure a new genetic syndrome.
Pilomatrixoma of the eyelid Rosa, Nicola; Lanza, Michele; Cennamo, Gilda ...
Journal of dermatological case reports,
07/2008, Letnik:
2, Številka:
2
Report
BACKGROUNDPilomatrixoma is a benign tumor of the hair follicle that can transform into a malignant lesion, the pilomatrix carcinoma. We present an unusual case of an eyelid pilomatrixoma. MAIN ...OBSERVATIONA 37-year-old white male presented with rapidly growing, pedunculated lesion located at the superior right eyelid of five months duration. The lesion was excised under local anaesthesia. The sample was fixed in 10% formalin and histopathological as well as immunohistochemical analyses were performed. Results of both examinations were consistent with a benign pilomatrixoma. CONCLUSIONSEven though the lesion had malignant clinical appearance, histopathology confirmed the diagnosis of a benign pilomatrixoma, supporting the decision not to make a more extensive surgery.
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