Highlights • CP−/− mice and mice that received FAC had high levels of brain iron. • Brain iron accumulation exacerbated TH-positive neurons apoptosis in MPTP-treated mice. • DFO reduced the neuronal ...damage in MPTP-treated CP−/− mice. • Increased oxidative stress was involved in cell apoptosis exacerbated by the increased brain iron.
Objective: Loneliness is a key public health issue for which various interventions have been trialed. However, few directly target the core feature of loneliness-lack of belonging. This is the focus ...of Groups 4 Health (G4H), a recently developed intervention that targets the development and maintenance of social group memberships to support health. Method: To investigate the efficacy of this intervention, a randomized controlled trial was conducted with participants (N = 120) assigned to G4H or treatment-as-usual (TAU) by computer software. Assessment of primary (loneliness) and secondary (depression, social anxiety, general practitioner visits, multiple group membership) outcomes was conducted at baseline and 2-month follow-up using mixed-model repeated-measures analyses. Results: G4H produced a greater reduction in loneliness (d = −1.04) and social anxiety (d = −0.46) than TAU (d = −0.33 and d = 0.03, respectively). G4H was also associated with fewer general practitioner visits at follow-up (d = −0.33) and a stronger sense of belonging to multiple groups (d = 0.52) relative to TAU (d = 0.30 and d = 0.33, respectively). Depression declined significantly in both G4H (d = −0.63) and TAU (d = −0.34), but follow-up analyses showed this was greater in G4H among those not receiving adjunct psychopharmacological treatment and whose symptoms were milder. Conclusions: Findings suggest that G4H can be a useful way to treat loneliness and highlight the importance of attending to group memberships when tackling this important social challenge.
What is the public health significance of this article?
This study demonstrates how an intervention derived from social identity theorizing can target social isolation and in so doing reduce loneliness and symptoms of depression and social anxiety.
The large-scale distribution of neutral hydrogen in the Universe will be luminous through its 21 cm emission. Here, for the first time, we use the auto-power spectrum of 21 cm intensity fluctuations ...to constrain neutral hydrogen fluctuations at z ∼ 0.8. Our data were acquired with the Green Bank Telescope and span the redshift range 0.6 < z < 1 over two fields totalling 41 deg2 and 190 h of radio integration time. The dominant synchrotron foregrounds exceed the signal by ∼103, but have fewer degrees of freedom and can be removed efficiently. Even in the presence of residual foregrounds, the auto-power can still be interpreted as an upper bound on the 21 cm signal. Our previous measurements of the cross-correlation of 21 cm intensity and the WiggleZ galaxy survey provide a lower bound. Through a Bayesian treatment of signal and foregrounds, we can combine both fields in auto- and cross-power into a measurement of ΩHI
bHI
= 0.62+0.23
−0.15 × 10−3 at 68 per cent confidence with 9 per cent systematic calibration uncertainty, where ΩHI
is the neutral hydrogen (H i) fraction and bHI
is the H i bias parameter. We describe observational challenges with the present data set and plans to overcome them.
The Large High Altitude Air Shower Observatory (LHAASO) is a new generation hybrid cosmic ray observatory which is expected to reveal the mystery of the origin of cosmic rays. The one square ...kilometer array (KM2A) consisting of 5195 Electromagnetic particle Detectors (ED) and 1188 Muon Detectors (MD) is a sub-array of LHAASO. The EDs are designed to measure the density and arriving time of the secondary particles of extensive air showers. The performance of the EDs is tested for the quality control after construction in the laboratory at sea level. In this paper, the performance of more than four thousands EDs is summarized. The performance of all tested EDs meets the design requirements with the time resolution of 1.6 ns, the detection efficiency of 97.8%, charge resolution for single particle of 18.5% and count rate around 480 Hz. Furthermore, one ED is singled out for monitoring of the long-term stability over a period of nearly two years from December 2018 to November 2020.
Abstract
We select the largest sample of Swift gamma-ray bursts (GRBs) so far to reexamine the classification in terms of time duration, hardness ratio, and physical collapse model. To analyze the ...sample selection effect, we divide the observed Swift GRB sample into four subsamples according to signal-to-noise level, spectral quality, and extended emission. First, we find that only the sample of Swift GRBs with well-measured peak energy can be evidently divided into two types at a boundary of ∼1 s, and other data sets are well described by three Gaussian functions. Using Swift GRBs with known redshift, a Kolmogorov–Smirnov test shows the intrinsic duration distributions of five data sets are equally distributed. Second, we ascertain in the plane of hardness ratio versus duration that the hardness ratio of short GRBs is significantly higher than those of middle classes and long GRBs, while the latter two components are the same in statistics, implying the so-called middle class to be artificial. Third, we apply a collapse model to discriminate the boundaries between collapse and noncollapse Swift bursts. It is interesting to find that a significant fraction, ≥30%, of Swift short GRBs could have originated from the collapsing progenitors, while all long GRBs are produced from the collapsars only. Finally, we point out that short GRBs with extended emission are the main contributors to the noncollapsar population with longer duration.
Abstract
We report the discovery of a new unidentified extended
γ
-ray source in the Galactic plane named LHAASO J0341+5258 with a pretrial significance of 8.2 standard deviations above 25 TeV. The ...best-fit position is R.A. = 55.°34 ± 0.°11 and decl. = 52.°97 ± 0.°07. The angular size of LHAASO J0341+5258 is 0.°29 ± 0.°06
stat
± 0.°02
sys
. The flux above 25 TeV is about 20% of the flux of the Crab Nebula. Although a power-law fit of the spectrum from 10 to 200 TeV with the photon index
α
= 2.98 ± 0.19
stat
± 0.02
sys
is not excluded, the LHAASO data together with the flux upper limit at 10 GeV set by the Fermi-LAT observation, indicate a noticeable steepening of an initially hard power-law spectrum with a cutoff at ≈50 TeV. We briefly discuss the origin of ultra-high-energy gamma rays. The lack of an energetic pulsar and a young supernova remnant inside or in the vicinity of LHAASO J0341+5258 challenge, but do not exclude, both the leptonic and hadronic scenarios of gamma-ray production.
Abstract
We report the discovery of an ultrahigh-energy (UHE) gamma-ray source, LHAASO J2108+5157, by analyzing the LHAASO-KM2A data of 308.33 live days. A significant excess of gamma ray–induced ...showers is observed in both energy bands of 25−100 and >100 TeV with 9.5
σ
and 8.5
σ
, respectively. This source is not significantly favored as an extended source with an angular extension smaller than the point-spread function of KM2A. The measured energy spectrum from 20 to 200 TeV can be approximately described by a power-law function with an index of −2.83 ± 0.18
stat
. A harder spectrum is demanded at lower energies considering the flux upper limit set by Fermi-LAT observations. The position of the gamma-ray emission is correlated with a giant molecular cloud, which favors a hadronic origin. No obvious counterparts have been found, and deeper multiwavelength observations will help to cast new light on this intriguing UHE source.
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