Abstract
Background
Inflammation is a major risk factor for frailty, but n-3 polyunsaturated fatty acids (PUFA) has been suggested as an anti-inflammatory agent. The present study aimed to ...investigate the hypothesis that the higher erythrocyte levels of long-chain n-3 PUFA were associated with lower odds of frailty and frailty criterion.
Methods
Cross-sectional analysis from the Korean Frailty and Aging Cohort Study, a total of 1,435 people aged 70–84 years were included. Sex- and age-stratified community residents, drawn in urban and rural regions nationwide, were eligible for participation in the study. All participants were categorized as frail and nonfrail according to the Cardiovascular Health Study index.
Results
The likelihood of frailty was inversely associated with the erythrocyte levels of eicosapentaenoic acid (EPA; odds ratio OR per unit 0.33; 95% confidence interval CI 0.14–0.77; p for trend = .002) and docosahexaenoic acid (DHA; OR per unit 0.42; 95% CI 0.20–0.87; p for trend = .018). Among each frailty criterion, the likelihood of slow walking speed was associated with erythrocyte levels of EPA and DHA, and the likelihood of exhaustion was inversely associated with the erythrocyte levels of DHA.
Conclusions
The present study showed that the frailty and frailty criterion were significantly associated with lower erythrocyte levels of long-chain n-3 PUFA, suggesting that lower n-3 PUFA could be a marker for the risk of frailty.
Age-related obesity and body composition changes include loss of muscle mass and increased body fat. This study aimed to investigate sex differences in the impact of sarcopenia, defined by the Asian ...Working Group for Sarcopenia (AWGS), on obesity in Korean older adults.
In this 2-year longitudinal study, 3014 participants were excluded based on AWGS sarcopenia parameters (if any one of the sarcopenic parameter criteria was satisfied), including low handgrip strength (HGS), low appendicular skeletal muscle mass index (ASMI), and low short physical performance battery (SPPB). A total of 926 non-sarcopenic participants were recruited for the study. The obese and non-obese groups were compared according to the sarcopenia parameters. The following variables were selected for obesity analysis: body mass index (BMI), waist circumference (WC), and body fat percentage. Unadjusted and fully adjusted logistic regression analyses were performed for each variable to predict sarcopenia and sarcopenic obesity according to sex.
Among the sarcopenia parameters, reduction in ASMI was significantly lower in the obese group with high WC and percentage of body fat (PBF) in both men and women (P < 0.01). Multivariable analysis revealed that different obesity parameters were associated with AWGS criteria: women in the high BMI group presented significantly lower ASMI and sarcopenia (ASMI, OR = 0.289, 95% CI = 0.174-0.480; sarcopenia, OR = 0.152, 95% CI = 0.048-0.483). Women in the high WC group had significantly lower ASMI and sarcopenia (ASMI, OR = 0.307, 95% CI = 0.189-0.500; sarcopenia, OR = 0.262, 95% CI = 0.106-0.649). Women in the high PBF group had a lower incidence of sarcopenia (OR = 0.214, 95% CI = 0.068-0.278).
Our study identified that high BMI had a protective effect on the reduction of muscle mass in men and women. However, obesity parameters including BMI, WC, and PBF were positively correlated with a lower incidence of sarcopenia only in women. Obesity in older women may have a protective effect in reducing ASMI and the incidence of sarcopenia.
Review on neutrophil migration from blood vessels, and the spatiotemporal regulation of the overall immune response.
Neutrophils are professional phagocytes that constitute the first line of defense ...in humans. The primary function of neutrophils is to eliminate invading pathogens through oxidative and nonoxidative mechanisms. Because neutrophils rapidly migrate into inflammatory foci via diapedesis and chemotaxis, neutrophil recruitment has long been considered a hallmark of inflammation. Recent advances in intravital microscopic technologies using animal model systems have enabled researchers to directly visualize neutrophil trafficking. Consequently, the specific mechanisms of neutrophil transmigration have been identified, and even the reverse migration of neutrophils can be verified visually. Moreover, the detailed phenomena of neutrophil infiltration into various organs, such as the liver, lymphoid organs, and CNS have been identified. This progress in the study of neutrophil migration from the blood vessels to organs results in a deeper understanding of these immune cells’ motility and morphology, which are closely related to the spatiotemporal regulation of the overall immune response. In this review, we discuss our current understanding of neutrophil trafficking in various organs.
•A combination of Deep-learning and CFD is proposed for source localization of hazardous chemical leak.•The proposed model predicts the source location in a chemical plant that has complex ...terrain.•The proposed LSTM-RNN model predicts the true source location with 97.1% accuracy.•Even if the prediction fails, a point of overlap within a radius of 10 m from the true source is derived.
Chemical leak accidents not properly handled at the early stage can spread to major industrial disasters escalating through fire and explosion. Therefore, it is very important to develop a method that enables prompt and systematic response by identifying the location of leakage source quickly and accurately and informing on-site personnel of the probable location(s). In this study, a model that predicts the suspicious leak location(s) in real-time, using sensor data, is proposed. Feed-forward neural network and recurrent neural network with long short-term memory that learned the data gathered from the installed sensors are proposed to predict the Top-5 points in the order of highest likelihood. In order to train and verify the neural networks, the sensor data generated from computational fluid dynamics simulations for a real chemical plant are used. The model learns the inverse problem solving for accident scenarios and predicts the leak point with very high accuracy.
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Aim
Physical frailty and sarcopenia are geriatric syndromes associated with adverse health outcomes. However, the common and different conditions associated with physical frailty and sarcopenia ...remain unclear. This study aimed to compare the clinical characteristics of older adults with physical frailty and sarcopenia.
Methods
This cross‐sectional study analyzed 2028 community‐dwelling older adults, aged 70–84 years (mean age 75.9 ± 4.0 years; 50.1% men). Physical frailty was defined using the Fried frailty phenotype, whereas sarcopenia was defined using the Asian Working Group for Sarcopenia 2014 and 2019 criteria.
Results
The prevalence of physical frailty was 5.5%, whereas that of sarcopenia, using the Asian Working Group for Sarcopenia 2014 and 2019, was 9.1% and 17.5%, respectively. The concordance of physical frailty with sarcopenia was higher in the Asian Working Group for Sarcopenia 2019 criteria than in 2014. Frail‐only participants had a higher incidence of disability, cognitive dysfunction, poor self‐perceived health, and depressive symptoms than the sarcopenic‐only participants. Frail‐and‐sarcopenic participants showed a lower body mass index (≥23 kg/m2) than frail‐only participants. Furthermore, in frail‐and‐sarcopenic participants, recurrent falls (16.9% vs 5.5%) were higher than in the neither‐frail‐nor‐sarcopenic participants; falls with fracture (11.5% vs 1.7%) and fear of falling (59.0% vs 36.7%) were higher in frail‐and‐sarcopenic participants than in sarcopenic‐only participants.
Conclusions
This study showed significant differences between physical frailty and sarcopenia among community‐dwelling older adults. Older adults with physical frailty and sarcopenia were more likely to have higher fall‐related outcomes than the others. Geriatr Gerontol Int 2022; 22: 42–49.
Rapid reduction in the price of photovoltaic (solar PV) cells and modules has resulted in a rapid increase in solar system deployments to an annual expected capacity of 200 GW by 2020. Achieving high ...PV cell and module efficiency is necessary for many solar manufacturers to break even. In addition, new innovative installation methods are emerging to complement the drive to lower $/W PV system price. The floating PV (FPV) solar market space has emerged as a method for utilizing the cool ambient environment of the FPV system near the water surface based on successful FPV module (FPVM) reliability studies that showed degradation rates below 0.5% p.a. with new encapsulation material. PV module temperature analysis is another critical area, governing the efficiency performance of solar cells and module. In this paper, data collected over five-minute intervals from a PV system over a year is analyzed. We use MATLAB to derived equation coefficients of predictable environmental variables to derive FPVM’s first module temperature operation models. When comparing the theoretical prediction to real field PV module operation temperature, the corresponding model errors range between 2% and 4% depending on number of equation coefficients incorporated. This study is useful in validation results of other studies that show FPV systems producing 10% more energy than other land based systems.
Highly pathogenic avian influenza virus (HPAIV) has caused widespread outbreaks in poultry in the Americas. Because of the duration and extent of these outbreaks, vaccine use may be an additional ...tool to limit virus spread. Three vaccines were evaluated for efficacy in chickens against a current North American clade 2.3.4.4b H5 HPAIV isolate, A/turkey/Indiana/3703-003/2022 H5N1. The vaccines included: 1) a commercial inactivated reverse genetics (rg) generated H5N1 product with a clade 2.3.4.4c H5 hemagglutinin (HA) (rgH5N1); 2) a commercial alphavirus RNA particle (RP) vaccine with the TK/IN/22 HA; and 3) an in-house inactivated rg produced vaccine with the TK/IN/22 HA and a North American lineage N9 neuraminidase (NA) (SEP-22-N9). Both inactivated vaccines were produced with HA genes that were modified to be low pathogenic and with the remaining genes from the PR8 influenza strain. All vaccines provided 100% protection against mortality and morbidity and all vaccines reduced virus shed by the oropharyngeal and cloacal routes significantly compared to sham vaccinates. However, differences were observed among the vaccines in quantities of virus shed at two- and four-days post challenge (DPC). To determine if infected birds could be identified after vaccination to aid surveillance programs, serum was collected from the RP and SEP-22-N9 vaccine groups at 7, 10, and 14 DPC to detect antibody to the NA and nucleoprotein (NP) of the challenge virus by enzyme linked lectin assay (ELLA) and ELISA. As early as 7DPC ELLA detected antibody in sera from 100% of the chickens in the RP vaccinated group and 70% of the chickens in the SEP-22-N9 vaccinated group. Antibody to the NP was detected by commercial ELISA in more than 50% of the birds in the RP vaccinated group at each time point.
Clinical and research interest in sarcopenia has burgeoned internationally, Asia included. The Asian Working Group for Sarcopenia (AWGS) 2014 consensus defined sarcopenia as "age-related loss of ...muscle mass, plus low muscle strength, and/or low physical performance" and specified cutoffs for each diagnostic component; research in Asia consequently flourished, prompting this update. AWGS 2019 retains the previous definition of sarcopenia but revises the diagnostic algorithm, protocols, and some criteria: low muscle strength is defined as handgrip strength <28 kg for men and <18 kg for women; criteria for low physical performance are 6-m walk <1.0 m/s, Short Physical Performance Battery score ≤9, or 5-time chair stand test ≥12 seconds. AWGS 2019 retains the original cutoffs for height-adjusted muscle mass: dual-energy X-ray absorptiometry, <7.0 kg/m
in men and <5.4 kg/m
in women; and bioimpedance, <7.0 kg/m
in men and <5.7 kg/m
in women. In addition, the AWGS 2019 update proposes separate algorithms for community vs hospital settings, which both begin by screening either calf circumference (<34 cm in men, <33 cm in women), SARC-F (≥4), or SARC-CalF (≥11), to facilitate earlier identification of people at risk for sarcopenia. Although skeletal muscle strength and mass are both still considered fundamental to a definitive clinical diagnosis, AWGS 2019 also introduces "possible sarcopenia," defined by either low muscle strength or low physical performance only, specifically for use in primary health care or community-based health promotion, to enable earlier lifestyle interventions. Although defining sarcopenia by body mass index-adjusted muscle mass instead of height-adjusted muscle mass may predict adverse outcomes better, more evidence is needed before changing current recommendations. Lifestyle interventions, especially exercise and nutritional supplementation, prevail as mainstays of treatment. Further research is needed to investigate potential long-term benefits of lifestyle interventions, nutritional supplements, or pharmacotherapy for sarcopenia in Asians.
Real-Time “Eye-Writing” Recognition Using Electrooculogram Lee, Kwang-Ryeol; Chang, Won-Du; Kim, Sungkean ...
IEEE transactions on neural systems and rehabilitation engineering,
2017-Jan., 2017-01-00, 2017-1-00, 20170101, Letnik:
25, Številka:
1
Journal Article
Recenzirano
Eye movements can be used as alternative inputs for human-computer interface (HCI) systems such as virtual or augmented reality systems as well as new communication ways for patients with locked-in ...syndrome. In this study, we developed a real-time electrooculogram (EOG)-based eye-writing recognition system, with which users can write predefined symbolic patterns with their volitional eye movements. For the "eye-writing" recognition, the proposed system first reconstructs the eye-written traces from EOG waveforms in real-time; then, the system recognizes the intended symbolic inputs with a reliable recognition rate by matching the input traces with the trained eye-written traces of diverse input patterns. Experiments with 20 participants showed an average recognition rate of 87.38% (F1 score) for 29 different symbolic patterns (26 lower case alphabet characters and three functional input patterns representing Space, Backspace, and Enter keys), demonstrating the promise of our EOG-based eye-writing recognition system in practical scenarios.
This letter presents transparent microstrip patch antennas made of two types of transparent conductive films, which are multilayer film (MLF; IZTO/Ag/IZTO) and metal-mesh film (MMF; Cu). The sheet ...resistance levels of the MLF and MMF are 2.52 and 0.18 Ω/□. The transparencies of the MLF and MMF are over 80% and 60% at a 550-nm wavelength, respectively. The design and dimensions of the antennas follow the conventional simple microstrip patch antenna. A transparent acryl substrate is used for the proposed transparent antennas. The conductive parts of the proposed antennas are also made of copper sheets (CS; case 1) for the performance comparison to two types of transparent antennas made of MLF (case 2) and MMF (case 3). The resonance frequency band of the antennas is 2.4-2.5 GHz for Wi-Fi service. The case-1, case-2, and case-3 antennas have peak gains of 4.75, -4.23, and 2.63 dB and have radiation efficiencies of 66.32%, 7.76%, and 42.69% at the center frequency of the Wi-Fi service band (2.45 GHz), respectively.
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