Antibiotic resistance (ABR) is a growing public health concern worldwide, and it is now regarded as a critical One Health issue. One Health's interconnected domains contribute to the emergence, ...evolution, and spread of antibiotic-resistant microorganisms on a local and global scale, which is a significant risk factor for global health. The persistence and spread of resistant microbial species, and the association of determinants at the human-animal-environment interface can alter microbial genomes, resulting in resistant superbugs in various niches. ABR is motivated by a well-established link between three domains: human, animal, and environmental health. As a result, addressing ABR through the One Health approach makes sense. Several countries have implemented national action plans based on the One Health approach to combat antibiotic-resistant microbes, following the Tripartite's Commitment Food and Agriculture Organization (FAO)-World Organization for Animal Health (OIE)-World Health Organization (WHO) guidelines. The ABR has been identified as a global health concern, and efforts are being made to mitigate this global health threat. To summarize, global interdisciplinary and unified approaches based on One Health principles are required to limit the ABR dissemination cycle, raise awareness and education about antibiotic use, and promote policy, advocacy, and antimicrobial stewardship.
This study evaluates the antioxidant activity of Ranunculus muricatus and isolation and structure elucidation of the active constituents. The aerial parts of the plants were shade dried at room ...temperature and powdered and extracted with methanol. The free radical scavenging activity was evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay. The percentage scavenging activity was determined based on the percentage of DPPH radical scavenged. Column chromatography was used in order to isolate the active compounds. Spectral techniques UV, IR,
H NMR,
CNMR and HREI-MS were used for the structure elucidation of the isolated compounds. Two isolated compounds, A (caffeoyl-β-D-glucopyranoside) and B (1,3-dihydroxy-2-tetracosanoylamino-4-(E)-nonadecene), exibited a significant antioxidant activity as showed by DPPH radical scavenging method. Percentage inhibition for compound A (at 0.5 mM) was 82.67 ± 0.19 with IC
of 93.25 ± 0.12 (μM), and for compound B (at 0.5 mM) was 69.23 ± 0.19 with IC
of 183.34 ± 0.13 (μM). Quercetin was used as standard control. It was conclued from the present study that caffeoyl-β-D-glucopyranoside and 1,3-dihydroxy-2-tetracosanoylamino-4-(E)-nonadecene isolated from methanol extract of aerial parts of Ranunculus muricatus posses antioxidant activity.
Klebsiella pneumoniae is ubiquitous and known to be a notorious pathogen of humans, animals, and plant-based foods.
K. pneumoniae
is a recognized trafficker of antibiotic resistance genes (ARGs) ...between and from different ecological niches. A total of 775 samples (
n
= 775) were collected from September 2017 to August 2019 from humans, animals, and environmental sources by applying the random convenient sampling technique. A total of 120 (15.7%) samples were confirmed as
K. pneumoniae
. The distribution of
K. pneumoniae
among humans, the environment, and animals was 17.1, 12.38, and 10%, respectively. Isolates have shown significant resistance against all the subjected antibiotics agents except colistin. ARGs profiling revealed that the highest percentage prevalence (67.5%) of
bla
CTX
–
M
was estimated in the isolates, and various carbapenem resistance genes that were found in the study were
bla
NDM
–1
(43.3%),
bla
OXA
–48
(38%), and (1.67%)
bla
KPC
–2
. Overall, 21 distinct sequence types (ST) and 13 clonal complexes (CCs) were found through the multi-locus sequence typing (MLST) analysis. Taking together, the distribution of multi-drug resistance (MDR)
K. pneumoniae
clones in the community and associated environment is alarming for the health care system of the country. Health policymakers should consider the role of all the integral parts of humans, animals, and the associated environment intently to cope with this serious public and animal health concern.
Some Results about Weak UP-algebras Chaudhry, Muhammad Anwar; Fahad, Asfand; Qureshi, Muhammad Imran ...
Journal of mathematics (Hidawi),
2022, Letnik:
2022
Journal Article
Recenzirano
Odprti dostop
We introduce a new class of algebras, weak UP-algebras, briefly written as WUP-algebras, as a wider class than the classes of UP-algebras and KU-algebras. We investigate fundamental aspects including ...maximal elements, branches and the subalgebra consisting of maximal elements of a WUP-algebra. We also study regular congruences on a WUP-algebra as well as the corresponding quotient WUP-algebras. We prove that the congruence generated from the branches of a WUP-algebra is regular and the corresponding quotient algebra χ/q is isomorphic to the WUP-algebra Maxχ, the subalgebra of χ consisting of its maximal elements.
Objective: To assess outcome of Left Atrial reduction plasty and sinus rhythm restoration in patients undergoing Mitral valve surgery with chronic Atrial Fibrillation.
Study Design: Longitudinal ...study.
Place and Duration of Study: Adult Cardiac Surgery Unit, Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi Pakistan, from Jan 2017-Jun 2022.
Methodology: Thirty three (n=33) patients with mitral valve disease were recruited via convenience sampling, all of whom exhibited an enlarged left atrium and pre-operative Atrial Fibrillation (AF). Pre-operative cardiac evaluations were performed using Transthoracic Echocardiography (TTE). Pre- and post-surgery trans-esophageal echocardiography studies were conducted as a routine procedure. Follow-up echocardiographic assessments were carried out at intervals of 1 month, 3 months, and 6 months, alongside Electrocardiograms (ECGs). During surgery, median sternotomy was done. Cardiopulmonary Bypass (CPB) time was established followed by cardiac arrest. After Mitral valve Repair/Replacement (MVR), Left Atrial (LA) plication was done by a double needle.
Results: Out of thirty three (n=33) patients, 25(75.7%) females and 8(24.2%) male patients, with mean age of 44.3±15.5 years, underwent mitral valve surgery(repair/replacement) followed by LA reduction & sinus rhythm restoration procedure. Complete restoration of sinus rhythm with re-appearance of “a” wave on echocardiography, signifying LA transport function through mitral valve was observed in 31(93.9%) patients on 3rd month and only 1(3.0%) individual continued to have persistent AF after 6 months. (83.70±2.50 mm vs. 47.50±1.08 mm) (p<0.001)...
Conclusion: Left atrial reduction by “Plication technique” followed by “Diathermy Fulguration” as a part of mitral valve surgery has yielded ...
Coronaviruses (CoVs) are enveloped, positive sense, single-stranded RNA viruses. The viruses have adapted to infect a large number of animal species, ranging from bats to camels. At present, seven ...CoVs infect humans, of which Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for causing the Coronavirus Disease 2019 (COVID-19) in humans. Since its emergence in late 2019, SARS-CoV-2 has spread rapidly across the globe. Healthcare systems around the globe have been stretched beyond their limits posing new challenges to emergency healthcare services and critical care. The outbreak continues to jeopardize human health, social life and economy. All known human CoVs have zoonotic origins. Recent detection of SARS-CoV-2 in pet, zoo and certain farm animals has highlighted its potential for reverse zoonosis. This scenario is particularly alarming, since these animals could be potential reservoirs for secondary zoonotic infections. In this article, we highlight interspecies SARS-CoV-2 infections and focus on the reverse zoonotic potential of this virus. We also emphasize the importance of potential secondary zoonotic events and the One-Health and One-World approach to tackle such future pandemics.
In this paper, we investigate an equivalent condition for a branchwise strongly solid gBCH-algebra to be branchwise commutative. Moreover, we show that a branchwise strongly solid gBCH-algebra is ...both branchwise commutative and branchwise positive implicative if and only if it is branchwise implicative.
The objective of this study was to evaluate the antibacterial and antioxidant activity of methanolic extract of Zaleya pentandra. It inhibited the growth of S. typhi, with zone of inhibition 13 mm at ...concentration 3 mg/100 µL and 11 mm at concentration 1.5 mg/100 µL. It also showed zone of inhibition against S. aureus with 17.5 mm and 12.5 mm at concentration 3 mg/100 µL in comparison to erythromycin with 15.6 mm. It showed 73% radical scavenging at concentration 161 µL/mL. The extract was fractioned by column chromatography using eluents (chloroform:methanol:H₂O). The isolation and purification afforded amorphous solid which was subjected to physical, chemical and spectral techniques UV, IR, ¹H-NMR, ¹³C-NMR and HREI-MS for the structure elucidation of the isolated compound. The compound was named pentandraol. From the present study, it was concluded that the methanolic extract of Zaleya pentandra has antibacterial and antioxidant activity and contains a novel compound named as pentandraol.
Chemical graph theory deals with the basic properties of a molecular graph. In graph theory, we correlate molecular descriptors to the properties of molecular structures. Here, we compute some ...Banhatti molecular descriptors for water-soluble dendritic unimolecular polyether micelle. Our results prove to be very significant to understand the behaviour of water-soluble dendritic unimolecular polyether micelle as a drug-delivery agent.
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