Caregivers play a major role in providing care for patients with Alzheimer's disease (AD) and are themselves at higher risk of health comorbidities.
To address the impact of neuropsychiatric symptoms ...of patients in different stages of AD on their caregivers' burden.
This prospective study enrolled 260 AD patients with clinical dementia rating (CDR) of 0.5, 1 and 2 at a tertiary medical center.
All patients were tested using the mini-mental state examination (MMSE), the cognitive abilities screening instrument (CASI), the neuropsychiatric inventory (NPI) and the CDR scale. Data regarding therapeutic outcomes of anti-Alzheimer's drugs were also collected. Caregivers were tested using NPI.
The mean follow-up interval was 25.0 ± 12.2 months, and two patients died during follow-up. NPI-burden was positively correlated with NPI-sum ( r = 0.822, P < 0.001) but negatively correlated with years of education ( r = -0.140, P = 0.024), CASI score ( r = -0.259, P < 0.001) and MMSE score ( r = -0.262, P <0.001). Multiple linear regression analysis showed that only NPI-sum was independently associated with mean NPI-burden. Both higher mean CASI and MMSE scores had better therapeutic outcome of anti-Alzheimer's drugs ( P = 0.001 and P = 0.005, respectively).
The severity of neuropsychiatric symptoms in patients with AD was positively associated with caregiver's stress, and patients with better cognitive functions, under treatment with anti-Alzheimer's drugs, had better therapeutic outcomes. To reduce the impact of neuropsychiatric symptoms, it is crucial to detect dementia in its early phases and provide early intervention with anti-Alzheimer's drugs, which might help decrease the caregiver burden, thereby improving their quality of life.
We present the first fully differential predictions for the production cross section of a Higgs boson via the gluon fusion mechanism at next-to-next-to-next-to-leading order ( N3 LO ) in QCD ...perturbation theory. Differential distributions are shown for the two-photon final state produced by the decay of the Higgs boson for a realistic set of fiducial cuts. The N3 LO corrections exhibit complex features and are in part larger than the inclusive N3 LO corrections to the production cross section. Overall, we observe that the inclusion of the N3 LO QCD corrections significantly reduces the perturbative uncertainties and leads to a stabilization of the perturbative expansion.
ABSTRACT We present high-resolution (0 16) 870 m Atacama Large Millimeter/submillimeter Array (ALMA) imaging of 16 luminous ( ) submillimeter galaxies (SMGs) from the ALESS survey of the Extended ...Chandra Deep Field South. This dust imaging traces the dust-obscured star formation in these galaxies on ∼1.3 kpc scales. The emission has a median effective radius of Re = 0 24 0 02, corresponding to a typical physical size of 1.8 0.2 kpc. We derive a median Sérsic index of n = 0.9 0.2, implying that the dust emission is remarkably disk-like at the current resolution and sensitivity. We use different weighting schemes with the visibilities to search for clumps on 0 12 (∼1.0 kpc) scales, but we find no significant evidence for clumping in the majority of cases. Indeed, we demonstrate using simulations that the observed morphologies are generally consistent with smooth exponential disks, suggesting that caution should be exercised when identifying candidate clumps in even moderate signal-to-noise ratio interferometric data. We compare our maps to comparable-resolution Hubble Space Telescope -band images, finding that the stellar morphologies appear significantly more extended and disturbed, and suggesting that major mergers may be responsible for driving the formation of the compact dust disks we observe. The stark contrast between the obscured and unobscured morphologies may also have implications for SED fitting routines that assume the dust is co-located with the optical/near-IR continuum emission. Finally, we discuss the potential of the current bursts of star formation to transform the observed galaxy sizes and light profiles, showing that the descendants of these SMGs are expected to have stellar masses, effective radii, and gas surface densities consistent with the most compact massive ( 1-2 × 1011 ) early-type galaxies observed locally.
Membrane transport proteins fulfill important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, ...capable of mediating transmembrane transport, have been successfully developed. However, to confer stimuli-responsiveness on them poses a fundamental challenge. Here we demonstrate photocontrol of transmembrane transport and electric potential using bis(thio)ureas derived from stiff-stilbene. UV–vis and 1H NMR spectroscopy are used to monitor E–Z photoisomerization of these bis(thio)ureas and 1H NMR titrations reveal stronger binding of chloride to the (Z)-form than to the (E)-form. Additional insight into the binding properties is provided by single crystal X-ray crystallographic analysis and DFT geometry optimization. Importantly, the (Z)-isomers are much more active in transmembrane transport than the respective (E)-isomers as shown through various assays. As a result, both membrane transport and depolarization can be modulated upon irradiation, opening up new prospects toward light-based therapeutics as well as physiological and optopharmacological tools for studying anion transport-associated diseases and to stimulate neuronal activity, respectively.
Abstract
Hot dust-obscured galaxies (DOGs) are hyperluminous (L8–1000 μm > 1013 L⊙) infrared galaxies with extremely high (up to hundreds of K) dust temperatures. The sources powering both their ...extremely high luminosities and dust temperatures are thought to be deeply buried and rapidly accreting supermassive black holes (SMBHs). Hot DOGs could therefore represent a key evolutionary phase in which the SMBH growth peaks. X-ray observations can be used to study their obscuration levels and luminosities. In this work, we present the X-ray properties of the 20 most luminous (Lbol ≳ 1014 L⊙) known hot DOGs at z = 2–4.6. Five of them are covered by long-exposure (10–70 ks) Chandra and XMM–Newton observations, with three being X-ray detected, and we study their individual properties. One of these sources (W0116−0505) is a Compton-thick candidate, with column density NH = (1.0–1.5) × 1024 cm−2 derived from X-ray spectral fitting. The remaining 15 hot DOGs have been targeted by a Chandra snapshot (3.1 ks) survey. None of these 15 are individually detected; therefore, we applied a stacking analysis to investigate their average emission. From hardness ratio analysis, we constrained the average obscuring column density and intrinsic luminosity to be log NH (cm−2) > 23.5 and LX ≳ 1044 erg s−1, which are consistent with results for individually detected sources. We also investigated the LX–L6 μm and LX–Lbol relations, finding hints that hot DOGs are typically X-ray weaker than expected, although larger samples of luminous obscured quasi-stellar objects are needed to derive solid conclusions.
We present subkiloparsec-scale mapping of the 870 m ALMA continuum emission in six luminous (LIR ∼ 5 × 1012 L ) submillimeter galaxies (SMGs) from the ALESS survey of the Extended Chandra Deep Field ...South. Our high-fidelity 0 07-resolution imaging (∼500 pc) reveals robust evidence for structures with deconvolved sizes of 0.5-1 kpc embedded within (dominant) exponential dust disks. The large-scale morphologies of the structures within some of the galaxies show clear curvature and/or clump-like structures bracketing elongated nuclear emission, suggestive of bars, star-forming rings, and spiral arms. In this interpretation, the ratio of the "ring" and "bar" radii (1.9 0.3) agrees with that measured for such features in local galaxies. These potential spiral/ring/bar structures would be consistent with the idea of tidal disturbances, with their detailed properties implying flat inner rotation curves and Toomre-unstable disks (Q < 1). The inferred one-dimensional velocity dispersions ( r 70-160 km s−1) are marginally consistent with the limits implied if the sizes of the largest structures are comparable to the Jeans length. We create maps of the star formation rate density ( SFR) on ∼500 pc scales and show that the SMGs are able to sustain a given (galaxy-averaged) SFR over much larger physical scales than local (ultra)luminous infrared galaxies. However, on 500 pc scales, they do not exceed the Eddington limit set by radiation pressure on dust. If confirmed by kinematics, the potential presence of nonaxisymmetric structures would provide a means for net angular momentum loss and efficient star formation, helping to explain the very high star formation rates measured in SMGs.
A
bstract
We derive the second-order QCD corrections to the production of a Higgs boson recoiling against a parton with finite transverse momentum, working in the effective field theory in which the ...top quark contributions are integrated out. To account for quark mass effects, we supplement the effective field theory result by the full quark mass dependence at leading order. Our calculation is fully differential in the final state kinematics and includes the decay of the Higgs boson to a photon pair. It allows one to make next-to-next-to-leading order (NNLO)-accurate theory predictions for Higgs-plus-jet final states and for the transverse momentum distribution of the Higgs boson, accounting for the experimental definition of the fiducial cross sections. The NNLO QCD corrections are found to be moderate and positive, they lead to a substantial reduction of the theory uncertainty on the predictions. We compare our results to 8 TeV LHC data from ATLAS and CMS. While the shape of the data is well-described for both experiments, we agree on the normalization only for CMS. By normalizing data and theory to the inclusive fiducial cross section for Higgs production, good agreement is found for both experiments, however at the expense of an increased theory uncertainty. We make predictions for Higgs production observables at the 13 TeV LHC, which are in good agreement with recent ATLAS data. At this energy, the leading order mass corrections to the effective field theory prediction become significant at large transverse momenta, and we discuss the resulting uncertainties on the predictions.
Background
Increased plasma nuclear and mitochondrial DNA levels may be connected to disease severity following spontaneous intra‐cerebral haemorrhage (ICH). This study tested the hypothesis that ...plasma nuclear and mitochondrial DNA levels are substantially increased in acute ICH and can predict treatment outcomes.
Methods
Serial plasma nuclear and mitochondrial DNA levels were examined in 60 consecutive patients admitted within 24 h after onset of spontaneous ICH and in 60 volunteer control subjects. Additional samples were obtained on days 4, 7, 10, and 14 after onset of ICH regardless of clinical deterioration.
Results
Only plasma nuclear DNA, not plasma mitochondrial DNA, levels in patients with spontaneous ICH significantly correlated with Glasgow Coma Scale (GCS) (r = −0.467, P = 0.001) and ICH volume (r = 0.515, P ≤ 0.001) on presentation. Plasma nuclear DNA levels increased significantly from day 1 to day 7 in patients with poor outcome. Higher plasma nuclear DNA levels (cut‐off value >18.7 ng/ml) on presentation were associated with poor outcomes in spontaneous ICH patients.
Conclusion
Plasma nuclear DNA levels reflect the severity of cerebral damage such that higher levels are associated with poorer outcome. Plasma nuclear DNA level can be considered a neuropathologic marker of acute spontaneous ICH.
We present detailed studies of a z = 2.12 submillimeter galaxy, ALESS67.1, using sub-arcsecond resolution ALMA, adaptive optics-aided VLT/SINFONI, and Hubble Space Telescope (HST)/CANDELS data to ...investigate the kinematics and spatial distributions of dust emission (870 m continuum), 12CO(J = 3-2), strong optical emission lines, and visible stars. Dynamical modeling of the optical emission lines suggests that ALESS67.1 is not a pure rotating disk but a merger, consistent with the apparent tidal features revealed in the HST imaging. Our sub-arcsecond resolution data set allows us to measure half-light radii for all the tracers, and we find a factor of 4-6 smaller sizes in dust continuum compared to all the other tracers, including 12CO; also, ultraviolet (UV) and H emission are significantly offset from the dust continuum. The spatial mismatch between the UV continuum and the cold dust and gas reservoir supports the explanation that geometrical effects are responsible for the offset of the dusty galaxy on the IRX-β diagram. Using a dynamical method we derive an , consistent with other submillimeter galaxies (SMGs) that also have resolved CO and dust measurements. Assuming a single value we also derive resolved gas and star formation rate surface densities, and find that the core region of the galaxy ( kpc) follows the trend of mergers on the Schmidt-Kennicutt relationship, whereas the outskirts ( kpc) lie on the locus of normal star-forming galaxies, suggesting different star formation efficiencies within one galaxy. Our results caution against using single size or morphology for different tracers of the star formation activity and gas content of galaxies, and therefore argue the need to use spatially resolved, multi-wavelength observations to interpret the properties of SMGs, and perhaps even for galaxies in general.
A
bstract
We present the colourful antenna subtraction method, a reformulation of the antenna subtraction scheme for next-to-next-to-leading order (NNLO) calculations in QCD. The aim of this new ...approach is to achieve a general and process-independent construction of the subtraction infrastructure at NNLO. We rely on the predictability of the infrared singularity structure of one- and two-loop amplitudes in colour space to generate virtual subtraction terms and, subsequently, we define an automatable procedure to systematically infer the expression of the real subtraction terms, guided by the correspondence between unintegrated and integrated antenna functions. To demonstrate the applicability of the described approach, we compute the full colour NNLO correction to gluonic three-jet production
pp
(
gg
)
→ ggg
, in the gluons-only assumption.
PDF
