We derive the neutrino flavor transition probabilities with the neutrino treated as a wave packet. The decoherence and dispersion effects from the wave-packet treatment show up as damping and ...phase-shifting of the plane-wave neutrino oscillation patterns. If the energy uncertainty in the initial neutrino wave packet is larger than around 0.01 of the neutrino energy, the decoherence and dispersion effects would degrade the sensitivity of reactor neutrino experiments to mass hierarchy measurement to lower than 3
σ
confidence level.
Mobile social networks (MSNs) have become increasingly popular in supporting many novel applications since emerging in the recent years. Their applications and services are of great interest to ...service providers, application developers, and users. This paper distinguishes MSNs from conventional social networks and provides a comprehensive survey of MSNs with regard to platforms, solutions, and designs of the overall system architecture. We review the popular MSN platforms and experimental solutions for existing MSN applications and services and present the dominant mobile operating systems on which MSNs are implemented. We then analyze and propose the overall architectural designs of conventional and future MSN systems. In particular, we present the architectural designs from two perspectives: from the client side to the server side, and from the wireless data transmission level to the terminal utilization level. We further introduce and compare the unique features, services, and key technologies of two generations of architectural designs of MSN systems. Then, we classify the existing MSN applications and propose one special form of MSN, i.e., vehicular social network, and demonstrate its unique features and challenges compared with common MSNs. Finally, we summarize the major challenges for on-going MSN research and outline possible future research directions.
Purpose
Numerous biomarkers of diabetic kidney disease (DKD) are associated with renal prognosis but head-to-head comparisons are lacking. This study aimed to examine the association of soluble tumor ...necrosis factor receptor type 1 (sTNFR1), fibroblast growth factor 21 (FGF-21), endocan, N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and renal outcomes of patients with or without clinical signs of DKD.
Methods
A total of 312 patients were enrolled in a prospective observational study that excluded individuals with estimated glomerular filtration rates (eGFR) < 30 mL/min/1.73 m
2
. Composite renal outcomes included either a > 30% decline in eGFR and worsening albuminuria or both from consecutive tests of blood/urine during a 3.5-year follow-up period.
Results
Higher sTNFR1 and FGF-21, rather than endocan and NT-pro-BNP, levels were associated with renal outcomes but the significance was lost after adjusting for confounders. However, sTNFR1 levels ≥ 9.79 pg/dL or FGF-21 levels ≥ 1.40 pg/dL were associated with renal outcomes after adjusting for the confounders (hazard ration HR 2.76, 95% confidence interval CI 1.36–5.60,
p
= 0.005 for sTNFR1 level; HR 1.95, 95% CI 1.03–3.69,
p
= 0.03 for FGF-21 level). The combination of both levels exhibited even better association with renal outcomes than did either one alone (adjusted HR 4.45, 95% CI 1.86–10.65,
p
= 0.001). The results were consistent among patients with preserved renal function and normoalbuminuria.
Conclusion
Both sTNFR1 and FGF-21 levels were associated with renal outcomes of in patients with type 2 diabetes, and the combination of the abovementioned markers exhibits better predictability.
A measurement of electron antineutrino oscillation by the Daya Bay Reactor Neutrino Experiment is described in detail. Six 2.9-GWth nuclear power reactors of the Daya Bay and Ling Ao nuclear power ...facilities served as intense sources of ν¯e’s. Comparison of the ν¯e rate and energy spectrum measured by antineutrino detectors far from the nuclear reactors (∼1500–1950 m) relative to detectors near the reactors (∼350–600 m) allowed a precise measurement of ν¯e disappearance. More than 2.5 million ν¯e inverse beta-decay interactions were observed, based on the combination of 217 days of operation of six antineutrino detectors (December, 2011–July, 2012) with a subsequent 1013 days using the complete configuration of eight detectors (October, 2012–July, 2015). The ν¯e rate observed at the far detectors relative to the near detectors showed a significant deficit, R=0.949±0.002(stat)±0.002(syst). The energy dependence of ν¯e disappearance showed the distinct variation predicted by neutrino oscillation. Analysis using an approximation for the three-flavor oscillation probability yielded the flavor-mixing angle sin22θ13=0.0841±0.0027(stat)±0.0019(syst) and the effective neutrino mass-squared difference of |Δmee2|=(2.50±0.06(stat)±0.06(syst))×10−3 eV2. Analysis using the exact three-flavor probability found Δm322=(2.45±0.06(stat)±0.06(syst))×10−3 eV2 assuming the normal neutrino mass hierarchy and Δm322=(−2.56±0.06(stat)±0.06(syst))×10−3 eV2 for the inverted hierarchy.
Objectives
To determine whether nutritional status can predict 3-year cognitive and functional decline, as well as 4-year all-cause mortality in older adults.
Design
Prospectively longitudinal cohort ...study.
Setting and participants
The study recruited 354 men aged 65 years and older in the veteran’s retirement community.
Measures
Baseline nutritional status was evaluated using the Mini-Nutritional Assessment-Short Form (MNA-SF). Cognitive function and Activities of Daily Living (ADL) function were determined by the Mini-Mental State Examination (MMSE) and the Barthel Index, respectively. Three-year cognitive and functional decline were respectively defined as a >3 point decrease in the MMSE scores and lower ADL scores than at baseline. Univariate and multivariable logistic regression analyses were conducted to identify nutritional status as a risk factor in poor outcome. The Kaplan-Meier method and Cox proportional regression models were used to estimate the effect of malnutrition risk on the mortality.
Results
According to MNS-SF, the prevalence of risk of malnutrition was 53.1% (188/354). Multivariate logistic regression found risk of malnutrition significantly associated with 3-year cognitive decline (Adjusted odds ratio OR 2.07, 95% Confidence Interval CI 1.05–4.08, P =0.036) and functional decline (Adjusted OR 1.83, 95% CI 1.01–3.34, P =0.047) compared with normal nutritional status. The hazard ratio (HR) for all-cause mortality was 1.8 times higher in residents at risk of malnutrition (Adjusted HR 1.82, 95% CI 1.19–2.79, P =0.006).
Conclusions
Our results provide strong evidence that risk of malnutrition can predict not only cognitive and functional decline but also risk of all-cause mortality in older men living in a veteran retirement’s community. Further longitudinal studies are needed to explore the causal relationship among nutrition, clinical outcomes, and the effect of an intervention for malnutrition.
Silver diamine fluoride (SDF) is found to promote remineralization and harden the carious lesion. Hydroxyapatite crystallization is a crucial process in remineralization; however, the role of SDF in ...crystal formation is unknown. We designed an in vitro experiment with calcium phosphate with different SDF concentrations (0.38, 1.52, 2.66, 3.80 mg/mL) to investigate the effect of this additive on the nucleation and growth of apatite crystals. Two control groups were also prepared—calcium phosphate (CaCl2·2H2O + K2HPO4 in buffer solution) and SDF (AgNH32F in buffer solution). After incubation at 37 oC for 24 h, the shape and organization of the crystals were examined by bright-field transmission electron microscopy and electron diffraction. Unit cell parameters of the obtained crystals were determined with powder X-ray diffraction. The vibrational and rotational modes of phosphate groups were analyzed with Raman microscopy. The transmission electron microscopy and selected-area electron diffraction confirmed that all solids precipitated within the SDF groups were crystalline and that there was a positive correlation between the increased percentage of crystal size and the concentration of SDF. The powder X-ray diffraction patterns indicated that fluorohydroxyapatite and silver chloride were formed in all the SDF groups. Compared with calcium phosphate control, a contraction of the unit cell in the a-direction but not the c-direction in SDF groups was revealed, which suggested that small localized fluoride anions substituted the hydroxyl anions in hydroxyapatite crystals. This was further evidenced by the Raman spectra, which displayed up-field shift of the phosphate band in all the SDF groups and confirmed that the chemical environment of the phosphate functionalities indeed changed. The results suggested that SDF reacted with calcium and phosphate ions and produced fluorohydroxyapatite. This preferential precipitation of fluorohydroxyapatite with reduced solubility could be one of the main factors for arrest of caries lesions treated with SDF.
Abstract Objectives This ex vivo study compared the physico-chemical structural differences between primary carious teeth biannually treated with silver diamine fluoride (SDF) and carious teeth ...without such treatment. Method Twelve carious primary upper-central incisors were collected from 6-year-old children. Six teeth had arrested caries after 24-month biannual SDF applications and 6 had active caries when there was no topical fluoride treatment. The mineral density, elemental contents, surface morphology, and crystal characteristics were assessed by micro-computed tomography (micro-CT), energy-dispersive X-ray spectrometry (EDX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Results Micro-CT examination revealed a superficial opaque band approximately 150 μm on the arrested cavitated dentinal lesion. This band was limited in the active carious lesion. EDX examination detected a higher intensity of calcium and phosphate of 150 μm in the surface zone than in the inner zone, but this zone was restricted in the active cavitated dentinal lesion. SEM examination indicated that the collagens were protected from being exposed in the arrested cavitated dentinal lesion, but were exposed in the active cavitated dentinal lesion. TEM examination suggested that remineralised hydroxyapatites were well aligned in the arrested cavitated dentinal lesion, while those in the active cavitated dentinal lesion indicated a random apatite arrangement. Conclusions A highly remineralised zone rich in calcium and phosphate was found on the arrested cavitated dentinal lesion of primary teeth with an SDF application. The collagens were protected from being exposed in the arrested cavitated dentinal lesion. Clinical significance Clinical SDF application positively influences dentine remineralisation.
Aims
Riemerella anatipestifer infections of goslings and ducklings can result in high mortality. Since there are at least 21 serotypes of R. anatipestifer, cross‐protection is an important goal for ...vaccine development.
Methods and Results
In this study, we evaluated the immunostimulatory effect of different immunization regimens – the traditional inactivated vaccine vs prime–boost regimens using DNA and protein subunit vaccines (DNA+subunit, subunit+subunit, subunit+inactivated and DNA+DNA). Results showed that, when compared to the inactivated vaccine, prime–boost regimens induced higher and up to 16‐week longer lasting levels of antibody responses, significantly elevated the percentage of the cytotoxic CD8+ T cell and higher expression levels of IFN‐γ, IL‐6 and IL‐12 mRNAs. Furthermore, as an indication of cross‐protection, sera from prime–boost regimens were able to recognize lysates of R. anatipestifer serotypes 1, 2 and 6.
Conclusions
Prime–boost regimens especially DNA‐prime and protein‐boost, induce strong long‐term immune response and may prove protective for breeder ducks requiring long‐term protection.
Significance and Impact of the Study
It is worth mentioning that the subunit+inactivated regimen group also elicited strong immune response. The cost of this regimen may only be half of the other prime–boost regimens, making this subunit + inactivated combination an attractive option.
ABSTRACT ALMA Cycle 2 observations of long-wavelength dust emission in 145 star-forming galaxies are used to probe the evolution of the star-forming interstellar medium (ISM). We also develop a ...physical basis and empirical calibration (with 72 low-z and z ∼ 2 galaxies) for using the dust continuum as a quantitative probe of ISM masses. The galaxies with the highest star formation rates (SFRs) at = 2.2 and 4.4 have gas masses up to 100 times that of the Milky Way and gas mass fractions reaching 50%-80%, i.e., gas masses 1-4× their stellar masses. We find a single high-z star formation law: yr−1-an approximately linear dependence on the ISM mass and an increased star formation efficiency per unit gas mass at higher redshift. Galaxies above the main sequence (MS) have larger gas masses but are converting their ISM into stars on a timescale only slightly shorter than those on the MS; thus, these "starbursts" are largely the result of having greatly increased gas masses rather than an increased efficiency of converting gas to stars. At z > 1, the entire population of star-forming galaxies has ∼2-5 times shorter gas depletion times than low-z galaxies. These shorter depletion times indicate a different mode of star formation in the early universe-most likely dynamically driven by compressive, high-dispersion gas motions-a natural consequence of the high gas accretion rates.
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