We compare Hubble Space Telescope observations of Jupiter's FUV auroras with contemporaneous conjugate Juno in situ observations in the equatorial middle magnetosphere of Jupiter. We show that bright ...patches on and equatorward of the main emission are associated with hot plasma injections driven by ongoing active magnetospheric convection. During the interval that Juno crossed the magnetic field lines threading the complex of auroral patches, a series of energetic particle injection signatures were observed, and immediately prior, the plasma data exhibited flux tube interchange events indicating ongoing convection. This presents the first direct evidence that auroral morphology previously termed “strong injections” is indeed a manifestation of magnetospheric injections, and that this morphology indicates that Jupiter's magnetosphere is undergoing an interval of active iogenic plasma outflow.
Plain Language Summary
Auroras, known as the “Northern (or Southern) Lights” on Earth, are spectacular manifestations of energetic processes occurring in the space environment of a planet. The behavior of Jupiter's magnetosphere is dominated by the planet's rapid rotation, along with the centrifugally‐driven outflow of plasma (ionized gas) originating from active volcanoes on the moon Io. A prominent auroral feature on Jupiter has for many years been interpreted as a sign that Jupiter's magnetosphere is undergoing active convection, in which plasma from Io “falls” away from the planet, to be replaced by hot, relatively empty “bubbles” known as injections, moving inward. This feature comprises prominent patches of bright emission that are often observed in Jupiter's auroras, though the evidence associating them with injections has been largely circumstantial. Here we show that the NASA Juno spacecraft flew through such injections in the equatorial magnetosphere on magnetic field lines mapping to a cluster of auroral patches as observed by HST. The Juno data also indicated the interval was characterized by signatures of convection and outflow of plasma originating from Io. This demonstrates that auroral patches are signatures of injections, and that auroral emissions are an important tool for diagnosing the behavior of planetary magnetospheres.
Key Points
Bright FUV auroral patches on Jupiter are associated with magnetospheric injections and magnetospheric convection
Hubble Space Telescope and Juno equatorial data show a cluster of patches is magnetically conjugate with energetic particle injections
The interval also exhibits flux tube interchange and lagging magnetic field associated with plasma mass outflow
Abstract
Background
The long-term consequences of COVID-19 remain unclear. There is concern a proportion of patients will progress to develop pulmonary fibrosis. We aimed to assess the temporal ...change in CXR infiltrates in a cohort of patients following hospitalisation for COVID-19.
Methods
We conducted a single-centre prospective cohort study of patients admitted to University Hospital Southampton with confirmed SARS-CoV2 infection between 20th March and 3rd June 2020. Patients were approached for standard-of-care follow-up 12-weeks after hospitalisation. Inpatient and follow-up CXRs were scored by the assessing clinician for extent of pulmonary infiltrates; 0–4 per lung (Nil = 0, < 25% = 1, 25–50% = 2, 51–75% = 3, > 75% = 4).
Results
101 patients with paired CXRs were included. Demographics: 53% male with a median (IQR) age 53.0 (45–63) years and length of stay 9 (5–17.5) days. The median CXR follow-up interval was 82 (77–86) days with median baseline and follow-up CXR scores of 4.0 (3–5) and 0.0 (0–1) respectively. 32% of patients had persistent CXR abnormality at 12-weeks. In multivariate analysis length of stay (LOS), smoking-status and obesity were identified as independent risk factors for persistent CXR abnormality. Serum LDH was significantly higher at baseline and at follow-up in patients with CXR abnormalities compared to those with resolution. A 5-point composite risk score (1-point each; LOS ≥ 15 days, Level 2/3 admission, LDH > 750 U/L, obesity and smoking-status) strongly predicted risk of persistent radiograph abnormality (0.81).
Conclusion
Persistent CXR abnormality 12-weeks post COVID-19 was common in this cohort. LOS, obesity, increased serum LDH, and smoking-status were risk factors for radiograph abnormality. These findings require further prospective validation.
The Juno spacecraft has crossed Jupiter's bow shock (BS) and magnetopause (MP) multiple times in the dawn sector (near 0600 local time), both during the approach to Jupiter and during the first three ...apojove periods. A survey of all of these crossings using the Juno field and particle instruments has been performed, with 51 bow shock and 97 magnetopause crossings being detected. The BS crossings ranged from 92 to 128 RJ with 1 encounter during the approach, 36 during the first apojove period, 0 on the second, and 14 during the third. The MP crossings ranged from 73 to 114 RJ, with 8 MP encounters during the approach, 40 encounters during the first apojove period, 24 encounters on the second, and 46 during the third. During the approach, Juno initially encountered an expanding magnetosphere resulting in a single BS and MP crossing, followed a few days later by a contracting magnetosphere, resulting in 7 more MP crossings and a BS crossing on the first outbound orbit at 92 RJ. The lack of BS crossings and the limited number of MP crossings during the second apojove period suggests a long period of an expanded magnetosphere, likely caused by a prolonged period of low solar wind dynamic pressure associated with a rarefaction region. The detection of BS crossings on the third apojove period suggests another period of a highly compressed magnetosphere.
Key Points
Multiple bow shock and magnetopause crossings provide important information on the size and dynamics of the magnetosphere
Variations in the number of crossings encountered and their location suggest a dynamic solar wind and magnetosphere interaction
Multiple bow shock crossings separated by only few minutes suggest either a highly variable solar wind or large‐scale variation in the flank region
This study investigates uniaxial compression behavior of focused ion beam (FIB) manufactured 1
1
1 nickel (Ni) small-scale pillars, ranging in diameter from approximately 25
μm to below 200
nm, in ...order to examine the effect of crystallographic orientation on the mechanical properties. This study is unique from other micro-pillar studies in that the 1
1
1 orientation has a considerably lower Schmid factor, and has multiple slip systems available. The 1
1
1 Ni pillars show a strong increase in yield stress and work hardening with decreasing diameter. The relationship between yield stress and diameter (
σ
y
∝
d
−0.69) matches well with previous small-scale pillar studies. Strain hardening, which has been inconsistently observed in other micro-pillar studies, is found to be a function of both diameter and orientation. Although the precise mechanism for hardening is unknown, transmission electron microscopy reveals dislocations throughout the pillar and into the base material suggesting that dislocation interactions and deformation below the pillar play a role in the observed strain hardening. Furthermore, a slight crystallographic rotation of the pillar is observed likely contributing to the observed mechanical properties. By exploring the role of crystallography on the plastic deformation behavior, this study provides additional insight into the nature of the size effect.
We report the first in situ observations of electron measurements at a Europa footprint tail (FPT) crossing in the auroral region. During its 12th science perijove pass, Juno crossed magnetic field ...lines connected to Europa's FPT. We find that electrons in the range ~0.4 to ~25 keV, with a characteristic energy of 3.6 ± 0.5 keV, precipitate into Jupiter's atmosphere to create the footprint aurora. The energy flux peaks at ~36 mW/m2, while the peak ultraviolet (UV) brightness is estimated at 37 kR. We estimate the peak electron density and temperature to be 17.3 cm−3 and 1.8 ± 0.1 keV, respectively. Using magnetic flux shell mapping, we estimate that the radial width of the interaction at Europa's orbit spans roughly 3.6 ± 1.0 Europa radii. In contrast to typical Io FPT crossings, the instrument background caused by penetrating energetic radiation (> ~5–10 MeV electrons) increased during the Europa FPT crossing.
Plain Language Summary
Jupiter's moons interact with Jupiter's space environment, or magnetosphere, and create auroral spots and tails in Jupiter's ionosphere. Io's aurora footprint on Jupiter is the strongest and most persistent of all moons, but Ganymede, Callisto, and Europa's auroral footprints are also routinely observed by remote platforms. NASA's Juno mission and its instrument suite occasionally fly through regions that are connected to the moon‐magnetosphere interactions. During these crossings, Juno samples the electrons and ions that create the aurora. This paper is the first report of electron measurements taken during a Juno crossing of Europa's tail. These measurements confirm previous results based on remote observations. Most importantly, they provide a sample of the conditions in the regions associated with Europa's footprint aurora in Jupiter's magnetosphere.
Key Points
This is the first report of in situ electron measurements of a Europa footprint tail crossing
Precipitating electron energies range from ~0.4 to ~25 keV with a characteristic energy of 3.6 keV, consistent with a low color ratio of the auroral emissions
The instrument background caused by > ~5–10 MeV penetrating electrons increased during the crossing, opposite to what is observed at Io
Integrating simultaneous in situ measurements of magnetic field fluctuations, precipitating electrons, and ultraviolet auroral emissions, we find that Alfvénic acceleration mechanisms are responsible ...for Ganymede's auroral footprint tail. Magnetic field perturbations exhibit enhanced Alfvénic activity with Poynting fluxes of ~100 mW/m2. These perturbations are capable of accelerating the observed broadband electrons with precipitating fluxes of ~11 mW/m2, such that Alfvénic power is transferred to electron acceleration with ~10% efficiency. The ultraviolet emissions are consistent with in situ electron measurements, indicating 13 ± 3 mW/m2 of precipitating electron flux. Juno crosses flux tubes with both upward and downward currents connected to the auroral tail exhibiting small‐scale structure. We identify an upward electron conic in the downward current region, possibly due to acceleration by inertial Alfvén waves near the Jovian ionosphere. In concert with in situ observations at Io's footprint tail, these results suggest that Alfvénic acceleration processes are broadly applicable to magnetosphere‐satellite interactions.
Plain Language Summary
Jupiter's moon Ganymede interacts with the planet's rapidly rotating magnetic field, which generates an aurora in the Jovian upper atmosphere. The Juno spacecraft crossed magnetic field lines connected to this aurora. We found that a specific type of wave, similar to a wave produced when a string is plucked, is responsible for accelerating the electrons sustaining this aurora. This type of interaction between a moon and the planet it orbits is likely a common process occurring at other exoplanetary systems.
Key Points
First in situ particles and fields measurements connected to Ganymede's auroral tail are reported
Alfvén wave activity is observed with Poynting fluxes of ~100 mW/m2 capable of accelerating electrons into the atmosphere
Ganymede's footprint tail contains electron populations consistent with Alfvénic acceleration and precipitating energy fluxes of ~11 mW/m2
The Lancet Respiratory Medicine Commission on drug-resistant tuberculosis was published in 2017, which comprehensively reviewed and provided recommendations on various aspects of the disease. Several ...key new developments regarding drug-resistant tuberculosis are outlined in this Commission Update. The WHO guidelines on treating drug-resistant tuberculosis were updated in 2019 with a reclassification of second line anti-tuberculosis drugs. An injection-free MDR tuberculosis treatment regimen is now recommended. Over the past 3 years, advances in treatment include the recognition of the safety and mortality benefit of bedaquiline, the finding that the 9-11 month injectable-based 'Bangladesh' regimen was non-inferior to longer regimens, and promising interim results of a novel 6 month 3-drug regimen (bedaquiline, pretomanid, and linezolid). Studies of explanted lungs from patients with drug-resistant tuberculosis have shown substantial drug-specific gradients across pulmonary cavities, suggesting that alternative dosing and drug delivery strategies are needed to reduce functional monotherapy at the site of disease. Several controversies are discussed including the optimal route of drug administration, optimal number of drugs constituting a regimen, selection of individual drugs for a regimen, duration of the regimen, and minimal desirable standards of antibiotic stewardship. Newer rapid nucleic acid amplification test platforms, including point-of-care systems that facilitate active case-finding, are discussed. The rapid diagnosis of resistance to other drugs, (notably fluoroquinolones), and detection of resistance by targeted or whole genome sequencing will probably change the diagnostic landscape in the near future.
Anti-tumour necrosis factor (TNF) monoclonal antibodies or soluble TNF receptors have become an invaluable treatment against chronic inflammatory diseases, such as rheumatoid arthritis, inflammatory ...bowel disease and psoriasis. Individuals who are treated with TNF antagonists are at an increased risk of reactivating latent infections, especially tuberculosis (TB). Following TNF antagonist therapy, the relative risk for TB is increased up to 25 times, depending on the clinical setting and the TNF antagonist used. Interferon-γ release assays or, as an alternative in individuals without a history of bacille Calmette-Guérin vaccination, tuberculin skin testing is recommended to screen all adult candidates for TNF antagonist treatment for the presence of latent infection with Mycobacterium tuberculosis. Moreover, paediatric practice suggests concomitant use of both the tuberculin skin test and an interferon-γ release assay, as there are insufficient data in children to recommend one test over the other. Consequently, targeted preventive chemotherapy is highly recommended for all individuals with persistent M. tuberculosis-specific immune responses undergoing TNF antagonist therapy as it significantly reduces the risk of progression to TB. This TBNET consensus statement summarises current knowledge and expert opinions and provides evidence-based recommendations to reduce the TB risk among candidates for TNF antagonist therapy.
Interchange instability is known to drive fast radial transport of particles in Jupiter's inner magnetosphere. Magnetic flux tubes associated with the interchange instability often coincide with ...changes in particle distributions and plasma waves, but further investigations are required to understand their detailed characteristics. We analyze representative interchange events observed by Juno, which exhibit intriguing features of particle distributions and plasma waves, including Z‐mode and whistler‐mode waves. These events occurred at an equatorial radial distance of ∼9 Jovian radii on the nightside, with Z‐mode waves observed at mid‐latitude and whistler‐mode waves near the equator. We calculate the linear growth rate of whistler‐mode and Z‐mode waves based on the observed plasma parameters and electron distributions and find that both waves can be locally generated within the interchanged flux tube. Our findings are important for understanding particle transport and generation of plasma waves in the magnetospheres of Jupiter and other planetary systems.
Plain Language Summary
The centrifugal interchange instability, which has been observed in rapidly rotating planets, like Saturn and Jupiter, moves cold plasmas inside of the magnetosphere further away, and transports hotter, less dense plasmas toward the inner magnetosphere. These moving flux tubes have been observed at Jupiter together with plasma waves, but their detailed characteristics are not fully understood. In the present study, we use observations from the Juno spacecraft to report multiple representative interchange events and evaluate the properties of energetic particles and plasma waves. Furthermore, we use linear theory to calculate the growth rates of Z‐mode and whistler‐mode waves during these events. Our findings reveal the typical features of plasma waves and particles during interchange events, which provide important insights into particle transport and generation of plasma waves at Jupiter and possibly other magnetized planets in our solar system and beyond.
Key Points
Several plasma transport events associated with interchange instability are identified alongside plasma waves using Juno observations
Linear growth rate analyses indicate that waves can be locally generated during interchange events due to anisotropic electron distributions
Our findings provide insights into electron transport and plasma wave dynamics during interchange events in planetary magnetospheres
PDF
