Résumé
L’élévation progressive du taux sérique d’antigène spécifique prostatique (PSA) survenant en cas de cancer de la prostate après prostatectomie totale est désignée comme une récidive ...biologique. Étant donné que le sulforaphane, substance naturelle, a été beaucoup étudié en tant qu’agent anticancéreux, nous avons effectué une étude en double insu, randomisée, multicentrique, contre placebo, en administrant du sulforaphane à 78 patients (âge moyen : 69 ± 6 ans) présentant une élévation du taux de PSA après prostatectomie totale. Le traitement comprenait une administration orale quotidienne de 60 mg de sulforaphane libre stabilisé pendant six mois (M0–M6) suivie de deux mois sans traitement (M6–M8). L’étude a été conçue pour détecter une diminution de 0,012 log (ng/ml)/mois de la pente logarithmique du PSA dans le groupe sulforaphane de M0 à M6. Ce critère d’évaluation primaire n’a pas été atteint. Concernant les critères d’évaluation secondaires, les courbes logarithmiques médianes de PSA étaient constamment inférieures chez les hommes traités par sulforaphane. Les variations moyennes du taux de PSA entre M6 et M0 étaient inférieures dans le groupe sulforaphane (+0,099 ± 0,341 ng/ml) par rapport au groupe placebo (+0,620 ± 1,417 ng/ml ;
p
= 0,0433). Le temps de doublement du PSA était 86 % plus long dans le groupe sulforaphane par rapport au groupe placebo (respectivement 28,9 et 15,5 mois). Les augmentations de PSA supérieures à 20 % à M6 étaient significativement supérieures dans le groupe placebo (71,8 %) par rapport au groupe sulforaphane (44,4 %) ;
p
= 0,0163. La compliance et la tolérance au traitement étaient très bonnes. Les effets du sulforaphane étaient remarquables dès trois mois de traitement (M3–M6). Après traitement, l’évolution des courbes du PSA de M6 à M8 est comparable dans les deux bras. Une administration quotidienne de sulforaphane libre semble prometteuse dans la prise en charge des récidives biologiques du cancer de la prostate après prostatectomie totale.
Decision trees are a machine learning technique more and more commonly used in high energy physics, while it has been widely used in the social sciences. After introducing the concepts of decision ...trees, this article focuses on its application in particle physics.
A high-granularity timing detector for the ATLAS phase-II upgrade Casado, M.P.; Adam Bourdarios, C.; Belfkir, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
2022, Letnik:
1032
Journal Article
Recenzirano
Odprti dostop
The large increase of pileup interactions is one of the main experimental challenges for the HL-LHC physics programme. A powerful new way to mitigate the effects of pileup is to use high-precision ...timing information to distinguish between collisions occurring close in space but well-separated in time. A High-Granularity Timing Detector, based on low gain avalanche detector technology, is therefore proposed for the ATLAS Phase-II upgrade. Covering the pseudorapidity region between 2.4 and 4.0, this device will improve the detector physics performance in the forward region. The typical number of hits per track in the detector was optimized so that the target average time resolution per track for a minimum-ionising particle is 30 ps at the start of lifetime, increasing to 50 ps at the end of HL-LHC operation. The high-precision timing information improves the pileup reduction to improve the forward object reconstruction, complementing the capabilities of the upgraded Inner Tracker (ITk) in the forward regions of ATLAS and leading to an improved performance for both jet and lepton reconstruction. These improvements in object reconstruction performance translate into sensitivity gains and enhance the reach of the ATLAS physics programme at the HL-LHC. In addition, the HGTD offers unique capabilities for the online and offline luminosity determination, an important requirement for precision physics measurements.
A measurement of the $ZZ$ production in the $\ell^{-}\ell^{+}\ell^{\prime -}\ell^{\prime +}$ and $\ell^{-}\ell^{+}\nu\bar{\nu}$ channels $(\ell = e, \mu)$ in proton--proton collisions at $\sqrt{s} = ...8$ TeV at the Large Hadron Collider at CERN, using data corresponding to an integrated luminosity of 20.3 fb$^{-1}$ collected by the ATLAS experiment in 2012 is presented. The fiducial cross sections for $ZZ\to\ell^{-}\ell^{+}\ell^{\prime -}\ell^{\prime +}$ and $ZZ\to \ell^{-}\ell^{+}\nu\bar{\nu}$ are measured in selected phase-space regions. The total cross section for $ZZ$ events produced with both $Z$ bosons in the mass range 66 to 116 GeV is measured from the combination of the two channels to be $7.3\pm0.4\textrm{(stat)}\pm0.3\textrm{(syst)}\pm0.2\textrm{(lumi)}$ pb, which is consistent with the Standard Model prediction of $6.6^{+0.7}_{-0.6}$ pb. The differential cross sections in bins of various kinematic variables are presented. The differential event yield as a function of the transverse momentum of the leading $Z$ boson is used to set limits on anomalous neutral triple gauge boson couplings in $ZZ$ production.
The top quark mass is measured in the $t\bar{t}\to$ dilepton channel (lepton $= e, \mu$) using ATLAS data recorded in the year 2012 at the LHC. The data were taken at a proton--proton centre-of-mass ...energy of $\sqrt{s}=$ 8 TeV and correspond to an integrated luminosity of about 20.2 fb$^{-1}$. Exploiting the template method, and using the distribution of invariant masses of lepton--b-jet pairs, the top quark mass is measured to be $m_{top} =$ 172.99 $\pm$ 0.41 (stat) $\pm$ 0.74 (syst) GeV, with a total uncertainty of 0.84 GeV. Finally, a combination with previous ATLAS $m_{top}$ measurements from $\sqrt{s}=$7 TeV data in the $t\bar{t}\to$ dilepton and $t\bar{t}\to$ lepton+jets channels results in $m_{top} =$ 172.84 $\pm$ 0.34 (stat) $\pm$ 0.61 (syst) GeV, with a total uncertainty of 0.70 GeV.
This paper describes a measurement of the inclusive top quark pair production cross-section ($\sigma_{t\bar{t}}$) with a data sample of 3.2 fb$^{-1}$ of proton--proton collisions at a centre-of-mass ...energy of $\sqrt{s}$=13 TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron--muon pair in the final state. Jets containing $b$-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two $b$-tagged jets are counted and used to determine simultaneously $\sigma_{t\bar{t}}$ and the efficiency to reconstruct and $b$-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be: $\sigma_{t\bar{t}}$= 818 $\pm$ 8 (stat) $\pm$ 27 (syst) $\pm$ 19 (lumi) $\pm$ 12 (beam) pb, where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented.
Two searches for new phenomena in final states containing a same-flavour opposite-lepton (electron or muon) pair, jets, and large missing transverse momentum are presented. These searches make use of ...proton--proton collision data, collected during 2015 and 2016 at a centre-of-mass energy $\sqrt{s}=13$ TeV by the ATLAS detector at the Large Hadron Collider, which correspond to an integrated luminosity of 14.7 fb$^{-1}$. Both searches target the pair production of supersymmetric particles, squarks or gluinos, which decay to final states containing a same-flavour opposite-sign lepton pair via one of two mechanisms: a leptonically decaying Z boson in the final state, leading to a peak in the dilepton invariant-mass distribution around the Z boson mass; and decays of neutralinos (e.g. $\tilde{\chi}_2^0 \rightarrow \ell^+\ell^- \tilde{\chi}_1^0$), yielding a kinematic endpoint in the dilepton invariant-mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted in simplified models of gluino-pair (squark-pair) production, and provide sensitivity to gluinos (squarks) with masses as large as 1.70 TeV (980 GeV).
Differential cross sections for the production of at least four jets have been measured in proton--proton collisions at $\sqrt{s} = 8$ TeV at the Large Hadron Collider using the ATLAS detector. The ...dataset corresponds to an integrated luminosity of 20.3 $fb^{-1}$. The cross sections, corrected for detector effects, are compared to leading-order and next-to-leading-order calculations as a function of the jet momenta, invariant masses, minimum and maximum opening angles and other kinematic variables.
This paper reports inclusive and differential measurements of the $t\bar{t}$ charge asymmetry $A_{\textrm{C}}$ in 20.3 fb$^{-1}$ of $\sqrt{s} = 8$ TeV $pp$ collisions recorded by the ATLAS experiment ...at the Large Hadron Collider at CERN. Three differential measurements are performed as a function of the invariant mass, transverse momentum and longitudinal boost of the $t\bar{t}$ system. The $t\bar{t}$ pairs are selected in the single-lepton channels ($e$ or $\mu$) with at least four jets, and a likelihood fit is used to reconstruct the $t\bar{t}$ event kinematics. A Bayesian unfolding procedure is performed to infer the asymmetry at parton level from the observed data distribution. The inclusive $t\bar{t}$ charge asymmetry is measured to be $A_{\textrm{C}} = 0.009 \pm 0.005$ (stat.$+$syst.). The inclusive and differential measurements are compatible with the values predicted by the Standard Model.
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