Objectives. The objective was to investigate whether a treatment with a needle stimulation pad (NSP) changes perceived pain and/or sensory thresholds in patients with chronic neck (NP) and lower back ...pain (BP). Methods. 40 patients with chronic NP and 42 patients with chronic BP were equally randomized to either treatment or waiting list control group. The treatment group self-administered a NSP over a period of 14 days. Pain ratings were recorded on numerical rating scales (NRSs). Mechanical detection thresholds (MDTs) and pressure pain thresholds (PPTs) were determined at the site of maximal pain and in the adjacent region, vibration detection thresholds (VDT) were measured at close spinal processes. The Northwick Park Neck Pain Questionnaire (NPQ) and the Oswestry Disability Index (ODI) were utilized for the NP and BP study, respectively. Results. NRS ratings were significantly reduced for the treatment groups compared to the control groups (NP: P=.021 and BP: P<.001), accompanied by a significant increase of PPT at pain maximum (NP: P=.032 and BP: P=.013). There was no effect on VDT and MDT. The NPQ showed also a significant improvement, but not the ODI. Conclusions. The mechanical NSP seems to be an effective treatment method for chronic NP and BP.
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 ...with high-grade serous carcinoma (HGSOC), to identify variants associated with residual disease. The most significant association with resection status was observed for rs72845444, upstream of MGMT, in HGSOC (p = 3.9 × 10
). In gene-based analyses, PPP2R5C was the most strongly associated gene in HGSOC after stage adjustment. In an independent set of 378 ovarian tumours from the AGO-OVAR 11 study, variants near MGMT and PPP2R5C correlated with methylation and transcript levels, and PPP2R5C mRNA levels predicted progression-free survival in patients with residual disease. MGMT encodes a DNA repair enzyme, and PPP2R5C encodes the B56γ subunit of the PP2A tumour suppressor. Our results link heritable variation at these two loci with resection status in HGSOC.
A series of RuN(6) dinuclear Ru-Hbpp complexes (Hbpp is the dinucleating tetraaza ligand 3,5-bis(pyridyl)pyrazole) of general formula {Ru(II)(R(2)-trpy)(MeCN)(2)(mu-R(1)-bpp)}3(+), 10(3+)-14(3+), ...(R(1) = H, Me, or NO(2). and R(2) = H, Me, MeO; see Scheme 1) has been prepared from their Cl(-) or AcO(-) bridged precursors. The complexes have been characterized by UV-vis, NMR, CV, and some by X-ray. Complexes 10(3+)-14(3+), Ru(2)(II,II), were oxidized by 1 equiv in solution, leading to the mixed valence Ru(2)(II,III) complexes 10(4+)-14(4+) containing one unpaired electron and were characterized by EPR and UV-vis-near-IR, which showed metal-centered spin and the presence of low-energy IVCT bands. The H(ab) parameter indicates a relatively strong electronic coupling between the two ruthenium centers (class II). Further two electron oxidation in solution of the 10(3+)-14(3+) led to the formation of EPR silent Ru(2)(II,III) complexes 10(5+)-14(5+), that were further characterized by UV-vis-NIR TD-DFT calculations are employed to assign the nature of the UV-vis transitions for the complexes in the various oxidation states, which are of metal to ligand charge transfer (MLCT) type for Ru(2)(II,II) and ligand to,m. metal charge transfer (LMCT) type for Ru(2)(III,II) and Ru(2)(III,III).
Tanz als eigene Wissenskultur zu begreifen, ist nicht selbstverständlich. Doch steht außer Frage, dass dem Tanzen Wissensformen zukommen, die aus Praxeologien und Theoriebildungen hervorgehen. Aber ...bildet die Tanzkunst auch eine Wissenskultur? Worin bestünde sie und welche Erkenntnisziele und Erfahrungswerte sind am Werk? Vor diesem Fragehorizont greift der Sammelband in bestehende Diskussionen ein, um aus interdisziplinärer Perspektive das intermediale Feld von Tanz und Wissen zu reflektieren. Namhafte Wissenschaftler_innen analysieren u.a. kulturtheoretische, ästhetische und politische Fragen einer hybriden Kultur, in der Wissen als Prozess begreifbar wird.
Chronic neck pain is a major public health problem with very few evidence-based complementary treatment options. This study aimed to test the efficacy of 12 weeks of a partner-delivered home-based ...cupping massage, compared to the same period of progressive muscle relaxation in patients with chronic non-specific neck pain. Patients were randomly assigned to self-directed cupping massage or progressive muscle relaxation. They were trained and asked to undertake the assigned treatment twice weekly for 12 weeks. Primary outcome measure was the current neck pain intensity (0-100 mm visual analog scale; VAS) after 12 weeks. Secondary outcome measures included pain on motion, affective pain perception, functional disability, psychological distress, wellbeing, health-related quality of life, pressure pain thresholds and adverse events. Sixty one patients (54.1 plus or minus 12.7 years; 73.8%female) were randomized to cupping massage (n = 30) or progressive muscle relaxation (n = 31). After treatment, both groups showed significantly less pain compared to baseline however without significant group differences. Significant effects in favor of cupping massage were only found for wellbeing and pressure pain thresholds. In conclusion, cupping massage is no more effective than progressive muscle relaxation in reducing chronic non-specific neck pain. Both therapies can be easily used at home and can reduce pain to a minimal clinically relevant extent. Cupping massage may however be better than PMR in improving well-being and decreasing pressure pain sensitivity but more studies with larger samples and longer follow-up periods are needed to confirm these results. Trial Registration ClinicalTrials.gov NCT01500330
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