The spread of COVID-19 caused by the SARS-CoV-2 virus has become a worldwide problem with devastating consequences. Here, we implement a comprehensive contact tracing and network analysis to find an ...optimized quarantine protocol to dismantle the chain of transmission of coronavirus with minimal disruptions to society. We track billions of anonymized GPS human mobility datapoints to monitor the evolution of the contact network of disease transmission before and after mass quarantines. As a consequence of the lockdowns, people's mobility decreases by 53%, which results in a drastic disintegration of the transmission network by 90%. However, this disintegration did not halt the spreading of the disease. Our analysis indicates that superspreading k-core structures persist in the transmission network to prolong the pandemic. Once the k-cores are identified, an optimized strategy to break the chain of transmission is to quarantine a minimal number of 'weak links' with high betweenness centrality connecting the large k-cores.
Patients with coronavirus disease 2019 (COVID‐19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels ...of interleukin (IL)‐2, IL‐4, IL‐6, IL‐10, IL‐12, chemokine (C‐X‐C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL‐6, CXCL8, and active tumor growth factor β1. Inflammatory syndromes of the central nervous system in COVID‐19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines. ANN NEUROL 2021;89:1041–1045
Abstract
Previous observations have shown that the ≲10 au, ≳400 K hot inner disk of the archetypal accretion outburst young stellar object, FU Ori, is dominated by viscous heating. To constrain dust ...properties in this region, we have performed radio observations toward this disk using the Karl G. Jansky Very Large Array in 2020 June–July, September, and November. We also performed complementary optical photometric monitoring observations. We found that the dust thermal emission from the hot inner disk mid-plane of FU Ori has been approximately stationary and the maximum dust grain size is ≳1.6 mm in this region. If the hot inner disk of FU Ori, which is inward of the 150–170 K water snowline, is turbulent (e.g., corresponding to a Sunyaev & Shakura viscous
α
t
≳ 0.1), or if the actual maximum grain size is still larger than the lower limit we presently constrain, then as suggested by the recent analytical calculations and the laboratory measurements, water-ice-free dust grains may be stickier than water-ice-coated dust grains in protoplanetary disks. Additionally, we find that the free–free emission and the Johnson
B-
and
V
-band magnitudes of these binary stars were brightening in 2016–2020. The optical and radio variability might be related to the dynamically evolving protostellar- or disk-accretion activities. Our results highlight that the hot inner disks of outbursting objects are important laboratories for testing models of dust grain growth. Given the active nature of such systems, to robustly diagnose the maximum dust grain sizes, it is important to carry out coordinated multiwavelength radio observations.
Angiotensin-converting enzyme (ACE) inhibitors are one of the most active classes for cardiovascular diseases and hypertension treatment. In this regard, developing active and non-toxic ACE ...inhibitors is still a continuous challenge. Furthermore, the literature survey shows that oxidative stress plays a significant role in the development of hypertension. Herein, glutathione's molecular structure and supramolecular arrangements are evaluated as a potential ACE inhibitor. The tripeptide molecular modeling by density functional theory, the electronic structure by the frontier molecular orbitals, and the molecular electrostatic potential map to understand the biochemical processes inside the cell were analyzed. The supramolecular arrangements were studied by Hirshfeld surfaces, quantum theory of atoms in molecules, and natural bond orbital analyses. They showed distinct patterns of intermolecular interactions in each polymorph, as well as distinct stabilizations of these. Additionally, the molecular docking study presented the interactions between the active site residues of the ACE and glutathione via seven hydrogen bonds. The pharmacophore design indicated that the hydrogen bond acceptors are necessary for the interaction of this ligand with the binding site. The results provide useful information for the development of GSH analogs with higher ACE inhibitor activity.
Several sets of reference regions have been used in the literature for the regional synthesis of observed and modelled climate and climate change information. A popular example is the series of ...reference regions used in the Intergovernmental Panel on Climate Change (IPCC) Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Adaptation (SREX). The SREX regions were slightly modified for the Fifth Assessment Report of the IPCC and used for reporting subcontinental observed and projected changes over a reduced number (33) of climatologically consistent regions encompassing a representative number of grid boxes. These regions are intended to allow analysis of atmospheric data over broad land or ocean regions and have been used as the basis for several popular spatially aggregated datasets, such as the Seasonal Mean Temperature and Precipitation in IPCC Regions for CMIP5 dataset.
Osteoporosis is a disease characterized by impairment of bone microarchitecture that causes high socioeconomic impacts in the world because of fractures and hospitalizations. Although dual-energy ...X-ray absorptiometry (DXA) is the gold standard for diagnosing the disease, access to DXA in developing countries is still limited due to its high cost, being present only in specialized hospitals. In this paper, we analyze the performance of Osseus, a low-cost portable device based on electromagnetic waves that measures the attenuation of the signal that crosses the medial phalanx of a patient's middle finger and was developed for osteoporosis screening. The analysis is carried out by predicting changes in bone mineral density using Osseus measurements and additional common risk factors used as input features to a set of supervised classification models, while the results from DXA are taken as target (real) values during the training of the machine learning algorithms. The dataset consisted of 505 patients who underwent osteoporosis screening with both devices (DXA and Osseus), of whom 21.8% were healthy and 78.2% had low bone mineral density or osteoporosis. A cross-validation with k-fold = 5 was considered in model training, while 20% of the whole dataset was used for testing. The obtained performance of the best model (Random Forest) presented a sensitivity of 0.853, a specificity of 0.879, and an F1 of 0.859. Since the Random Forest (RF) algorithm allows some interpretability of its results (through the impurity check), we were able to identify the most important variables in the classification of osteoporosis. The results showed that the most important variables were age, body mass index, and the signal attenuation provided by Osseus. The RF model, when used together with Osseus measurements, is effective in screening patients and facilitates the early diagnosis of osteoporosis. The main advantages of such early screening are the reduction of costs associated with exams, surgeries, treatments, and hospitalizations, as well as improved quality of life for patients.
ALMA Observations of the HD 110058 Debris Disk Hales, Antonio S.; Marino, Sebastián; Sheehan, Patrick D. ...
Astrophysical journal/The Astrophysical journal,
12/2022, Letnik:
940, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Abstract
We present Atacama Large Millimeter/submillimeter Array (ALMA) observations of the young, gas-rich debris disk around HD 110058 at 0.″3–0.″6 resolution. The disk is detected in the 0.85 and ...1.3 mm continuum, as well as the
J
= 2–1 and
J
= 3–2 transitions of
12
CO and
13
CO. The observations resolve the dust and gas distributions and reveal that this is the smallest debris disk around stars of similar luminosity observed by ALMA. The new ALMA data confirm the disk is very close to edge-on, as shown previously in scattered-light images. We use radiative transfer modeling to constrain the physical properties of dust and gas disks. The dust density peaks at around 31 au and has a smooth outer edge that extends out to ∼70 au. Interestingly, the dust emission is marginally resolved along the minor axis, which indicates that it is vertically thick if truly close to edge-on with an aspect ratio between 0.13 and 0.28. We also find that the CO gas distribution is more compact than the dust (similar to the disk around 49 Ceti), which could be due to a low viscosity and a higher gas release rate at small radii. Using simulations of the gas evolution taking into account the CO photodissociation, shielding, and viscous evolution, we find that HD 110058's CO gas mass and distribution are consistent with a secondary origin scenario. Finally, we find that the gas densities may be high enough to cause the outward drift of small dust grains in the disk.
We report new Atacama Large Millimeter/submillimeter Array Band 3 (86-100 GHz; ∼80 mas angular resolution) and Band 4 (146-160 GHz; ∼50 mas angular resolution) observations of the dust continuum ...emission toward the archetypal and ongoing accretion burst young stellar object FU Ori, which simultaneously covered its companion, FU Ori S. In addition, we present near-infrared (2-2.45 m) observations of FU Ori taken with the General Relativity Analysis via VLT InTerferometrY (GRAVITY; ∼1 mas angular resolution) instrument on the Very Large Telescope Interferometer (VLTI). We find that the emission in both FU Ori and FU Ori S at (sub)millimeter and near-infrared bands is dominated by structures inward of ∼10 au radii. We detected closure phases close to zero from FU Ori with VLTI/GRAVITY, which indicate the source is approximately centrally symmetric and therefore is likely viewed nearly face-on. Our simple model to fit the GRAVITY data shows that the inner 0.4 au radii of the FU Ori disk has a triangular spectral shape at 2-2.45 m, which is consistent with the H2O and CO absorption features in a 10−4 M yr−1, viscously heated accretion disk. At larger (∼0.4-10 au) radii, our analysis shows that viscous heating may also explain the observed (sub)millimeter and centimeter spectral energy distribution when we assume a constant, ∼10−4 M yr−1 mass inflow rate in this region. This explains how the inner 0.4 au disk is replenished with mass at a modest rate, such that it neither depletes nor accumulates significant masses over its short dynamic timescale. Finally, we tentatively detect evidence of vertical dust settling in the inner 10 au of the FU Ori disk, but confirmation requires more complete spectral sampling in the centimeter bands.
Obesity is a major risk factor for cardiometabolic disease, but the effect of body composition on vascular aging and arterial stiffness remains uncertain. We investigated relationships among body ...composition, blood pressure, age, and aortic pulse wave velocity in healthy individuals. Pulse wave velocity in the thoracic aorta, an indicator of central arterial stiffness, was measured in 221 volunteers (range, 18-72 years; mean, 40.3±13 years) who had no history of cardiovascular disease using cardiovascular MRI. In univariate analyses, age (r=0.78; P<0.001) and blood pressure (r=0.41; P<0.001) showed a strong positive association with pulse wave velocity. In multivariate analysis, after adjustment for age, sex, and mean arterial blood pressure, elevated body fat% was associated with reduced aortic stiffness until the age of 50 years, thereafter adiposity had an increasingly positive association with aortic stiffness (β=0.16; P<0.001). Body fat% was positively associated with cardiac output when age, sex, height, and absolute lean mass were adjusted for (β=0.23; P=0.002). These findings suggest that the cardiovascular system of young adults may be capable of adapting to the state of obesity and that an adverse association between body fat and aortic stiffness is only apparent in later life.
Abstract Reintroducing apprehended wild animal in a natural environment is a complex process that involves many steps, including rehabilitating individuals and ensuring viable populations for ...reproduction; as such, the proportion between males and females to be reintroduced need to be considered carefully. The need of specialized techniques to identify sex on species that do not present discernible sexual dimorphisms can be a hardship to a successful reintroduction. Amazona aestiva, one of the most apprehended species on Brazil, is an example of such case, as sexing techniques employed for it often involves molecular or surgical procedures. Some authors, however, describe potential sexual dimorphisms that could be discernible to the human eye, one of those being an iris color dichromatism between males and females that could present a more conventional way to discern sex on this species. We analyzed the viability of sex identification by direct observation of iris sexual dichromatism, comparing suggestions by professionals familiarized with the species to molecular sexing by Polymerase Chain Reaction (PCR) and measuring color similarity between individuals using digital colorimetry. We found no significant correspondence between sex indication based on direct observation and molecular sexing results, and no relationship between iris color and sex by colorimetric analysis.
PDF
