Today, human iodine deficiency is, after iron, the most common nutritional deficiency in developed European and underdeveloped third world countries. A current biological indicator of iodine status ...is urinary iodine, which reflects very recent iodine exposure; a long-term indicator of iodine status remains to be identified.
We analyzed hair iodine in a prospective, observational, cross-sectional, and exploratory study involving 870 apparently healthy Croatians (270 men and 600 women). Hair iodine was analyzed with inductively coupled plasma mass spectrometry.
The hair iodine median was 0.499 μg/g, and was 0.482 and 0.508 μg/g for men and women respectively, suggesting no sex-related difference. We studied hair iodine uptake by analyzing the logistic sigmoid saturation curve of the median derivatives to assess iodine deficiency, adequacy, and excess. We estimated overt iodine deficiency to occur when hair iodine concentration was below 0.1-0.15 μg/g. Then there was a saturation range interval of about 0.1-2.0 μg/g where the deposition of iodine in the hair was linearly increasing (R(2)=0.994). Eventually, the sigmoid curve became saturated at about 2.0 μg/g and upward, suggesting excessive iodine exposure.
Hair appears to be a valuable and robust biological indicator tissue for assessing long-term iodine status. We propose that an adequate iodine status corresponds with hair iodine uptake saturation of 0.565-0.739 μg/g (55-65%).
Environmental exposure to silver (Ag) was assessed in occupationally non-exposed adult human population by analyzing Ag in the hair (H · Ag) and whole blood (WB · Ag). H · Ag was analyzed in 311 (123 ...men, M; 188 women, W); while WB · Ag was determined in 235 of these individuals (90 M, 145 W). Women had more H · Ag than men (M 0.05 vs. W 0.076), whereas WB · Ag concentrations in men and women were not significantly different. A natural distribution of the median derivatives was utilized to generate the dataset to fit the logistic sigmoid curve to assess the current human body burden of environmental Ag population exposure for M and W separately. The H · Ag (µg g⁻¹) below 0.0105 for M and 0.0145 for W, reflects low level of environmental Ag exposure. The adaptive physiological saturation phase followed where H · Ag rose rapidly, first for M and then for W in parallel with biological assay. Both parallel saturation curves converged and plateaued at 0.215 for M and 0.965 for W (µg g⁻¹). The current level of human environmental Ag exposure is low, but cases of high Ag exposure occurred sporadically. In conjunction with the medical histories overt clinical neural toxicity may be expected for H · Ag at 4 µg g⁻¹and higher. There were no significant correlation between the H · Ag and WB · Ag.
Involuntary emotional expression disorder (IEED) is syndrome characterized with relatively stereotypical episodes of uncontrollable crying and/or laughing. Additionally, this syndrome can include ...irritability, anger and frustration. This syndrome is common among a number of neurologic diseases like patients with a stroke or traumatic brain injury (TBI), patients with amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), as well as dementias such as Alzheimer's disease (AD), and motor disorders such as Parkinson's disease (PD). IEED is very common but misdiagnosed and consequently undertreated. Prevalence of IEED in AD is between 15-39%. Recent controlled clinical studies suggest that dextromethorphan (DM) and quinidine (Q) is an effective treatment for IEED. United States Food and Drug Administration (FDA) has accepted for filing and review its New Drug Application (NDA) for Zenvia (dextromethorphan hydrobromide and quinidine sulfate capsules) for the treatment of IEED. In Republic of Croatia current treatment involves antidepressants (tricyclic and selective serotonin reuptake inhibitors), antipsychotic agents, anxiolytics, antidementives and mood stabilizers. New promising treatment can reduce the frequency of episodes and improve the quality of life of patients and their families and caregivers.
Cilj rada bio je ispitati učinke učestalog izlaganja kriznim situacijama u pandemiji na psihičko zdravlje medicinskih
sestara/tehničara s naglaskom na simptome sagorijevanja i posttraumatskog stresa ...te razine psihološke otpornosti
na zadovoljstvo životom. U istraživanju, provedenom na Odjelu za zdravstvene studije Sveučilišta u Splitu u
Hrvatskoj, sudjelovalo je 125 medicinskih sestara/tehničara. Razina sindroma sagorijevanja ispitana je upitnikom
intenziteta sagorijevanja na poslu, simptomi posttraumatskog stresa procijenjeni su posttraumatskim upitnikom
za poremećaj stresa, psihološka otpornost procijenjena je ljestvicom za kratku otpornost, za procjenu općeg
zadovoljstva životom korištena je ljestvica zadovoljstva životom. Nakon dvogodišnjeg rada tijekom pandemije
COVID-19 otprilike 30 % medicinskih sestara/tehničara prijavilo je simptome posttraumatskog stresnog
poremećaja i visok stupanj sagorijevanja. Simptomi sagorijevanja i posttraumatskog stresa nisu se pokazali
povezanima sa zadovoljstvom životom. Međutim, psihološka otpornost je pozitivno povezana sa zadovoljstvom
životom, čak i nakon kontrole učinka sagorijevanja i posttraumatskog stresa. Pandemija COVID-19 je velik izazov
za zdravstvene sustave diljem svijeta s visokim stopama sagorijevanja i simptoma PTSP-a među zdravstvenim
radnicima. Važnost psihološke otpornosti naglašava se kao čimbenik u promicanju psihičkog zdravlja među
zdravstvenim radnicima.
The antipsychotic drugs can be of great benefit for the wide range of psychotic disorders, but all are associated with various adverse effects. Patients with psychotic disorder consider the sexual ...dysfunction to be among the most important side effects. Although, it is not uncommon for the patients with schizophrenia to report the sexual dysfunction, patients with untreated schizophrenia have fewer dysfunctions compared to those on antipsychotic medication. The decision whether the current treatment with a prolactin-increasing antipsychotic or sexual dysfunction inducing drug should be continued or switched to another antipsychotic drug, has to be made on the basis of the patient's risk-benefit estimation. It has to be kept on mind that adverse effects are usually dose dependent. In this case report, sertindole treated patient with chronic schizophrenia developed sexual side effect manifested as ejaculatory dysfunction that was significantly ameliorated by drug-dose reduction.
Considerable number of intellectual disabled people experience some form of disruptive behavior. Antipsychotics are the most common treatment for these behaviors. Numerous patients were efficiently ...treated with thioridazine, recently withdrawn. The authors describe a case series of "thioridazine responders" treated with olanzapine. Thirty three patients with severe intellectual disability were recruited. All patients were assessed for seven types of disruptive behavior on five point scale. Patients with severe behavior disturbances were included in treatment. The time points of assessment were at day 0, 30, 60 and 180. Twenty one patient accomplished inclusion criteria. A significant decrease occurred at day 30 for all types of behavior. Total score, self injurious behavior, compulsive and destructive behavior showed further decrease at day 60 and became stable until the end of study. Olanzapine appears to be efficacious in the treatment of disruptive behavior in the intellectually disabled and could be substitute for thioridazine treatment.
To assess the key characteristics related to living conditions and health in the Bayash Roma population in Baranja and Medimurje regions of Croatia and identify possible demographic and ...socio-economic sources of variance in self-reported health and reproductive profile.
The study comprised a total of 266 adult Bayash individuals from Baranja and 164 from Medimurje (aged 41.3+/-15.1 years). Data on ethno-historical and demographic background, self-identity, life and hygiene conditions, education, employment, health insurance, and health (dietary and smoking habits, reproductive characteristics, diagnosed and undiagnosed health problems, use of medications). were obtained through interviews. Bivariate and multivariate methods were used in statistical analyses.
The reported migratory pattern demonstrated that 88.8% of the examinees were born in the region of residence, which showed that the Bayash population was autochthonous and sedentary one. Financially, the Bayash primarily relayed on social welfare support allowance (84%) and child allowance (47%), while merely 2% were permanently and 23% occasionally employed. The proportion of the Bayash who had never attended school amounted to 33.3% (19.3% men and 40.6% women). The access to public water supply system was available to 52.5% of examinees, whereas only 1.7% had public sewage system, and 23.4% had private septic tanks. The most commonly reported health burden were frequent headaches (20.3%), stomach pain (16.3%), anxiety or insomnia (13.1%), hypertension (9.3%), and chronic obstructive pulmonary disease (COPD) (8.6%). The logistic regression identified level of education (odds ratio OR, 0.77; 95% confidence interval CI, 0.63-0.94) and access to health insurance (OR, 4.32; 95% CI, 1.46-12.77) as socio-economic/life-style factors playing a significant role in the occurrence of COPD.
Our results indicate poor inclusion of the Bayash in the essential social service sectors such as health care, education, and employment, as well as substandard living conditions and unfavorable health-related behavior. Since education and health insurance were found to have significant effects on the observed reproductive status and self-reported health, they should be targeted in planning public health actions for socially marginalized and economically deprived groups.
SEKSUALNE NUSPOJAVE ANTIPSIHOTIKA MIMICA, NINOSLAV; UZUN, SUZANA; KOZUMPLIK, OLIVER ...
Acta medica Croatica,
04/2019, Letnik:
73, Številka:
1
Journal Article
Odprti dostop
Istraživanja su pokazala da seksualna disfunkcija kao nuspojava liječenja psihofarmacima bitno utječe na kvalitetu života i održavanje partnerskih veza. Rezultati istraživanja pokazuju da simptomi ...seksualne disfunkcije koji se javljaju tijekom liječenja više zabrinjavaju psihičke bolesnike nego ekstrapiramidni simptomi. Seksualne disfunkcije opisane su kod 50 % bolesnica na terapiji psihofarmacima. Unatoč mišljenju većine psihijatara da je seksualno funkcioniranje važno za pacijente, dvije trećine psihijatara uobičajeno ne postavlja pacijentima pitanja o seksualnom funkcioniranju. Stoga se seksualna disfunkcija kao nuspojava psihofarmaka nedovoljno često prepoznaje i liječi. Atipični antipsihotici imaju brojne potencijalne prednosti u odnosu na tipične antipsihotike s obzirom na njihov učinak na seksualno funkcioniranje. Pažnju je potrebno usmjeriti na hiperprolaktinemiju tijekom dugotrajnog liječenja, posebno kod primjene visokih doza, osoba ženskog spola, osoba s ranijim početkom bolesti i kod teških bolesnika. Prema rezultatima istraživanja podatci ukazuju da se povezanost između seksualne disfunkcije i psihopatologije odnosila samo na žene. Stoga, prigodom vođenja brige o pacijentima osnovno je razmotriti spolno-specifi čne odnose između psihopatologije i seksualnih problema. Kod muškaraca liječenih antipsihoticima opisane su različite vrste seksualnih disfunkcija uključujući erektilnu, ejakulatornu i orgazmičku. Seksualnoj disfunkciji induciranoj antipsihoticima treba pristupiti uvažavajući osjetljivost i individualne potrebe svakog bolesnika. Zaključno možemo reći da su seksualne disfunkcije kod primjene novijih antipsihotika značajan i često slabo prepoznati problem. Adekvatnim izborom atipičnog antipsihotika s odgovarajućim farmakološkim profi lom smanjuje se mogućnost pojave seksualnih poteškoća. Buduća istraživanja novih lijekova trebaju uzeti u obzir javljanje seksualnih disfunkcija.
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