The separation of molecules with similar size and shape is an important technological challenge. For example, rare gases can pose either an economic opportunity or an environmental hazard and there ...is a need to separate these spherical molecules selectively at low concentrations in air. Likewise, chiral molecules are important building blocks for pharmaceuticals, but chiral enantiomers, by definition, have identical size and shape, and their separation can be challenging. Here we show that a porous organic cage molecule has unprecedented performance in the solid state for the separation of rare gases, such as krypton and xenon. The selectivity arises from a precise size match between the rare gas and the organic cage cavity, as predicted by molecular simulations. Breakthrough experiments demonstrate real practical potential for the separation of krypton, xenon and radon from air at concentrations of only a few parts per million. We also demonstrate selective binding of chiral organic molecules such as 1-phenylethanol, suggesting applications in enantioselective separation.
The use of biodigesters and the circular economy (CE) has been gaining attention in recent years. Both biodigesters and CE have the potential to minimize negative impacts—not only environmental, but ...also economic and social. However, little attention has been paid to the relationship between biodigesters and CE. Therefore, the objective of this paper is to identify and analyze the implications of the use of biodigesters in the light of a CE concept. To do this, a SWOT matrix was developed based on the opinion of experts and two case studies were conducted in companies operating in different sectors in Brazil. The results showed that the use of biodigesters can drive CE through biogas, which is a renewable energy source, closing the cycle of organic materials, increasing the economic power of companies and small producers, improving basic sanitation in remote areas, and stimulating industrial symbiosis. However, this study identified barriers in the use of biodigesters in the context of CE, such as lack of government incentives and composting being shown to be more cost-effective than the use of biodigesters for the treatment of solid waste.
Using the new capabilities of Spitzer and extensive multiwavelength data from SINGS, it is now possible to study the infrared properties of star formation in nearby galaxies down to scales equivalent ...to large H II regions. We are therefore able to determine what fraction of large, infrared-selected star-forming regions in normal galaxies are highly obscured and address how much of the star formation we miss by relying solely on the optical portion of the spectrum. Employing a new empirical method for deriving attenuations of infrared-selected star-forming regions, we investigate the statistics of obscured star formation on 500 pc scales in a sample of 38 nearby galaxies. We find that the median attenuation is 1.4 mag in H alpha and that there is no evidence for a substantial subpopulation of uniformly highly obscured star-forming regions. The regions in the highly obscured tail of the attenuation distribution ( unk unk 3) make up only similar to 4% of the sample of nearly 1800 regions, although very embedded infrared sources on the much smaller scales and lower luminosities of compact and ultracompact H II regions are almost certainly present in greater numbers. The highly obscured cases in our sample are generally the bright, central regions of galaxies with high overall attenuation but are not otherwise remarkable. We also find that a majority of the galaxies show decreasing radial trends in H alpha attenuation. The small fraction of highly obscured regions seen in this sample of normal, star-forming galaxies suggests that on 500 pc scales the timescale for significant dispersal or breakup of nearby, optically thick dust clouds is short relative to the lifetime of a typical star-forming region.
To assess survival and identify predictors of survival in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated in the Scleroderma Lung Studies (SLS) I and II.
SLS I ...randomised 158 patients with SSc-ILD to 1 year of oral cyclophosphamide (CYC) vs placebo. SLS II randomised 142 patients to 1 year of oral CYC followed by 1 year of placebo vs 2 years of mycophenolate mofetil. Counting process Cox proportional hazard modelling identified variables associated with long-term mortality in SLS I and II. Internal validation was performed using joint modelling.
After a median follow-up of 8 years, 42% of SLS I patients died, and when known the cause of death was most often attributable to SSc. There was no significant difference in the time to death between treatment arms in SLS I or II. Higher baseline skin score, older age, and a decline in the forced vital capacity (FVC) and the diffusing capacity for carbon monoxide (DLCO) over 2 years were independently associated with an increased risk of mortality in SLS I. The Cox model identified the same mortality predictor variables using the SLS II data.
In addition to identifying traditional mortality risk factors in SSc (skin score, age), this study demonstrated that a decline in FVC and DLCO over 2 years was a better predictor of mortality than baseline FVC and DLCO. These findings suggest that short-term changes in surrogate measures of SSc-ILD progression may have important effects on long-term outcomes.
Over the past five years, considerable work has been carried out in the exploration of candidate diluted oxide magnetic semiconductors with high Curie temperatures. Fueled by early experimental ...results and theoretical predictions, claims of ferromagnetism at and above room temperature in doped oxides have abounded. In general, neither the true nature of these materials nor the physical causes of the magnetism have been adequately determined. It is now apparent that these dilute magnetic systems are deceptively complex. We consider two well-characterizedn-type magnetically doped oxide semiconductors and explore the relationship between donor electrons and ferromagnetism.
The interplay of eustatic and isostatic factors causes complex relative sea‐level (RSL) histories, particularly in paraglacial settings. In this context the past record of RSL is important in ...understanding ice‐sheet history, earth rheology and resulting glacio‐isostatic adjustment. Field data to develop sea‐level reconstructions are often limited to shallow depths and uncertainty exists as to the veracity of modelled sea‐level curves. We use seismic stratigraphy, 39 vibrocores and 26 radiocarbon dates to investigate the deglacial history of Belfast Lough, Northern Ireland, and reconstruct past RSL. A typical sequence of till, glacimarine and Holocene sediments is preserved. Two sea‐level lowstands (both max. −40 m) are recorded at c. 13.5 and 11.5k cal a bp. Each is followed by a rapid transgression and subsequent periods of RSL stability. The first transgression coincides temporally with a late stage of Meltwater Pulse 1a and the RSL stability occurred between c. 13.0 and c. 12.2k cal a bp (Younger Dryas). The second still/slowstand occurred between c. 10.3 and c. 11.5k cal a bp. Our data provide constraints on the direction and timing of RSL change during deglaciation. Application of the Depth of Closure concept adds an error term to sea‐level reconstructions based on seismic stratigraphic reconstructions.
Although the cellular functions of TSC2 and its protein product, tuberin, are not known, somatic mutations in the TSC2 tumor suppressor gene are associated with tumor development in ...lymphangioleiomyomatosis (LAM). We found that ribosomal protein S6 (S6), which exerts translational control of protein synthesis and is required for cell growth, is hyperphosphorylated in the smooth muscle-like cell lesions of LAM patients compared with smooth muscle cells from normal human blood vessels and trachea. Smooth muscle (SM) cells derived from these lesions (LAMD-SM) also exhibited S6 hyperphosphorylation, constitutive activation of p70 S6 kinase (p70S6K), and increased basal DNA synthesis. In parallel, TSC2-/- smooth muscle cells (ELT3) and TSC2-/- epithelial cells (ERC15) also exhibited hyperphosphorylation of S6, constitutive activation of p70S6K, and increased basal DNA synthesis. Re-introduction of wild type tuberin into LAMD-SM, ELT3, and ERC15 cells abolished phosphorylation of S6 and significantly inhibited p70S6K activity and DNA synthesis. Rapamycin, an immunosuppressant, inhibited hyperphosphorylation of S6, p70S6K activation, and DNA synthesis in LAMD-SM cells. Interestingly, the basal levels of phosphatidylinositol 3-kinase, Akt/protein kinase B, and p42/p44 MAPK activation were unchanged in LAMD-SM and ELT3 cells relative to levels in normal human tracheal and vascular SM. These data demonstrate that tuberin negatively regulates the activity of S6 and p70S6K specifically, and suggest a potential mechanism for abnormal cell growth in LAM.
Aims. We aim to demonstrate the usability of mm-wavelength imaging data obtained from the APEX-SZ bolometer array to derive the radial temperature profile of the hot intra-cluster gas out to radius ...r500 and beyond. The goal is to study the physical properties of the intra-cluster gas by using a non-parametric de-projection method that is, aside from the assumption of spherical symmetry, free from modeling bias. Methods. We use publicly available X-ray spectroscopic-imaging data in the 0.7-2 keV energy band from the XMM-Newton observatory and our Sunyaev-Zel'dovich Effect (SZE) imaging data from the APEX-SZ experiment at 150 GHz to de-project the density and temperature profiles for a well-studied relaxed cluster, Abell 2204. We derive the gas density, temperature and entropy profiles assuming spherical symmetry, and obtain the total mass profile under the assumption of hydrostatic equilibrium. For comparison with X-ray spectroscopic temperature models, a re-analysis of recent Chandra observation is done with the latest calibration updates. We compare the results with that from an unrelaxed cluster, Abell 2163, to illustrate some differences between relaxed and merging systems. Results. Using the non-parametric modeling, we demonstrate a decrease of gas temperature in the cluster outskirts, and also measure gas entropy profiles, both of which are done for the first time independently of X-ray spectroscopy using the SZE and X-ray imaging data. The gas entropy measurement in the central 100 kpc shows the usability of APEX-SZ data for inferring cluster dynamical states with this method. The contribution of the SZE systematic uncertainties in measuring Te at large radii is shown to be small compared to XMM-Newton and Chandra systematic spectroscopic errors. The total mass profile obtained using the hydrostatic equilibrium assumption is in agreement with the published X-ray and weak lensing results; the upper limit on M200 derived from the non-parametric method is consistent with the NFW model prediction from weak lensing analysis.
Objective
Bipolar disorder (BP) frequently co‐occurs with other psychiatric disorders. We examine whether course of anxiety disorders (ANX), attention deficit hyperactivity disorder (ADHD), ...disruptive behavior disorders (DBD), and substance use disorders (SUD) influence likelihood of recovery and recurrence of depression and mania in BP youth.
Method
Weekly ratings of psychiatric disorder intensity were obtained from 413 participants of the Course and Outcome of BP Youth project, followed for an average of 7.75 years. Multiple‐event Cox proportional hazards regression analyses examined worsening of comorbid disorders as predictors of mood episode recovery and recurrence.
Results
Increased severity in ANX and SUD predicted longer time to recovery and less time to next depressive episode, and less time to next manic episode. Multivariate models with ANX and SUD found that significant effects of ANX remained, but SUD only predicted longer time to depression recovery. Increased severity of ADHD and DBD predicted shorter time to recurrence for depressive and manic episodes.
Conclusion
There are significant time‐varying relationships between the course of comorbid disorders and episodicity of depression and mania in BP youth. Worsening of comorbid conditions may present as a precursor to mood episode recurrence or warn of mood episode protraction.
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